SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1im5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		4 / 7 ASP A  52
TYR A 132
ASP A  10
HIS A  58
 ZN  A 400 (-2.5A)
None
None
None
 1.26A 1t03A-1im5A:
undetectable		 1t03A-1im5A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 120
GLU A   4
GLU A   3
 None
 0.68A 2nv4A-1im5A:
undetectable		 2nv4A-1im5A:
22.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WT9_A_NIOA1216_1
(NICOTINAMIDASE)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A  10
ASP A  52
HIS A  54
TYR A 103
CYH A 133
 None
ZN  A 400 (-2.5A)
ZN  A 400 (-3.3A)
None
None
 1.36A 2wt9A-1im5A:
27.4		 2wt9A-1im5A:
35.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WT9_A_NIOA1216_1
(NICOTINAMIDASE)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		9 / 10 ASP A  10
PHE A  15
LEU A  21
ASP A  52
TRP A  68
HIS A  71
TYR A 103
ALA A 129
CYH A 133
 None
None
None
ZN  A 400 (-2.5A)
None
ZN  A 400 (-3.4A)
None
None
None
 0.63A 2wt9A-1im5A:
27.4		 2wt9A-1im5A:
35.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WT9_A_NIOA1216_1
(NICOTINAMIDASE)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A  10
PHE A  15
LEU A  21
TRP A  68
TYR A 132
 None
 1.39A 2wt9A-1im5A:
27.4		 2wt9A-1im5A:
35.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WT9_B_NIOB1216_1
(NICOTINAMIDASE)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		8 / 9 ASP A  10
PHE A  15
LEU A  21
ASP A  52
TRP A  68
HIS A  71
ALA A 129
CYH A 133
 None
None
None
ZN  A 400 (-2.5A)
None
ZN  A 400 (-3.4A)
None
None
 0.53A 2wt9B-1im5A:
27.4		 2wt9B-1im5A:
35.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A  10
PHE A  15
ASP A  52
GLU A 101
TYR A 103
 None
None
ZN  A 400 (-2.5A)
ZN  A 400 ( 4.1A)
None
 1.09A 3o94A-1im5A:
26.1		 3o94A-1im5A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		6 / 11 ASP A  10
PHE A  15
LEU A  21
ASP A  52
HIS A  71
TYR A 103
 None
None
None
ZN  A 400 (-2.5A)
ZN  A 400 (-3.4A)
None
 0.63A 3o94A-1im5A:
26.1		 3o94A-1im5A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A  10
PHE A  15
ASP A  52
GLU A 101
TYR A 103
 None
None
ZN  A 400 (-2.5A)
ZN  A 400 ( 4.1A)
None
 1.10A 3o94B-1im5A:
26.0		 3o94B-1im5A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		6 / 11 ASP A  10
PHE A  15
LEU A  21
ASP A  52
HIS A  71
TYR A 103
 None
None
None
ZN  A 400 (-2.5A)
ZN  A 400 (-3.4A)
None
 0.63A 3o94B-1im5A:
26.0		 3o94B-1im5A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A  10
PHE A  15
ASP A  52
GLU A 101
TYR A 103
 None
None
ZN  A 400 (-2.5A)
ZN  A 400 ( 4.1A)
None
 1.11A 3o94C-1im5A:
25.9		 3o94C-1im5A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		6 / 11 ASP A  10
PHE A  15
LEU A  21
ASP A  52
HIS A  71
TYR A 103
 None
None
None
ZN  A 400 (-2.5A)
ZN  A 400 (-3.4A)
None
 0.64A 3o94C-1im5A:
25.9		 3o94C-1im5A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A  10
PHE A  15
ASP A  52
GLU A 101
TYR A 103
 None
None
ZN  A 400 (-2.5A)
ZN  A 400 ( 4.1A)
None
 1.10A 3o94D-1im5A:
25.9		 3o94D-1im5A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		6 / 11 ASP A  10
PHE A  15
LEU A  21
ASP A  52
HIS A  71
TYR A 103
 None
None
None
ZN  A 400 (-2.5A)
ZN  A 400 (-3.4A)
None
 0.64A 3o94D-1im5A:
25.9		 3o94D-1im5A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_A_NIOA311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		7 / 9 ASP A  10
LEU A  21
ASP A  52
TRP A  68
HIS A  71
LYS A  94
ALA A 129
 None
None
ZN  A 400 (-2.5A)
None
ZN  A 400 (-3.4A)
None
None
 0.61A 3r2jA-1im5A:
28.3		 3r2jA-1im5A:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		9 / 11 ASP A  10
PHE A  15
LEU A  21
ASP A  52
TRP A  68
HIS A  71
LYS A  94
TYR A 103
ALA A 129
 None
None
None
ZN  A 400 (-2.5A)
None
ZN  A 400 (-3.4A)
None
None
None
 0.67A 3r2jB-1im5A:
27.9		 3r2jB-1im5A:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A  10
PHE A  15
LEU A  21
TRP A  68
TYR A 132
 None
 1.46A 3r2jB-1im5A:
27.9		 3r2jB-1im5A:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A  10
PHE A  15
LYS A  94
ALA A 129
CYH A 133
 None
 1.25A 3r2jB-1im5A:
27.9		 3r2jB-1im5A:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		10 / 12 ASP A  10
PHE A  15
LEU A  21
ASP A  52
HIS A  54
TRP A  68
HIS A  71
LYS A  94
TYR A 103
ALA A 129
 None
None
None
ZN  A 400 (-2.5A)
ZN  A 400 (-3.3A)
None
ZN  A 400 (-3.4A)
None
None
None
 0.52A 3r2jC-1im5A:
28.4		 3r2jC-1im5A:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A  10
PHE A  15
LYS A  94
ALA A 129
CYH A 133
 None
 1.19A 3r2jC-1im5A:
28.4		 3r2jC-1im5A:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		9 / 11 ASP A  10
PHE A  15
LEU A  21
ASP A  52
TRP A  68
HIS A  71
LYS A  94
TYR A 103
ALA A 129
 None
None
None
ZN  A 400 (-2.5A)
None
ZN  A 400 (-3.4A)
None
None
None
 0.62A 3r2jD-1im5A:
28.0		 3r2jD-1im5A:
34.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A  22
GLY A  19
GLY A  18
GLY A 127
ASP A  27
 None
 0.98A 4fp9A-1im5A:
undetectable		 4fp9A-1im5A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A  22
GLY A  19
GLY A  18
GLY A 127
ASP A  27
 None
 0.97A 4fp9C-1im5A:
undetectable		 4fp9C-1im5A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A  22
GLY A  19
GLY A  18
GLY A 127
ASP A  27
 None
 0.96A 4fp9F-1im5A:
undetectable		 4fp9F-1im5A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		4 / 5 THR A  50
GLY A 105
GLU A 101
ASP A  10
 None
None
ZN  A 400 ( 4.1A)
None
 1.15A 5c0oH-1im5A:
4.1		 5c0oH-1im5A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1im5 180AA LONG
HYPOTHETICAL
PYRAZINAMIDASE/NICOT
INAMIDASE
(Pyrococcus
horikoshii) 		3 / 3 ALA A  20
PHE A  15
GLN A  12
 None
 0.73A 6eceA-1im5A:
undetectable		 6eceA-1im5A:
21.15