SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1im8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 1im8 YECO
(Haemophilus
influenzae) 		3 / 3 TRP A 228
ALA A 239
VAL A 160
 None
 0.99A 1av2C-1im8A:
undetectable
1av2D-1im8A:
undetectable		 1av2C-1im8A:
4.82
1av2D-1im8A:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1im8 YECO
(Haemophilus
influenzae) 		3 / 3 GLY A  63
ASP A  88
ASN A 131
 SAI  A 302 (-3.8A)
SAI  A 302 (-2.8A)
SAI  A 302 (-4.1A)
 0.56A 1vq1A-1im8A:
11.8		 1vq1A-1im8A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 1im8 YECO
(Haemophilus
influenzae) 		4 / 7 ALA A  69
SER A  72
ASP A  61
ILE A  41
 SAI  A 302 ( 3.9A)
None
SAI  A 302 ( 4.8A)
None
 0.94A 1yc5A-1im8A:
3.2		 1yc5A-1im8A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 1im8 YECO
(Haemophilus
influenzae) 		5 / 11 LEU A 130
LEU A 161
ILE A 149
ALA A 239
LEU A 153
 None
 1.21A 2q72A-1im8A:
undetectable		 2q72A-1im8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 1im8 YECO
(Haemophilus
influenzae) 		5 / 12 LEU A 130
LEU A 161
ILE A 149
ALA A 239
LEU A 153
 None
 1.16A 2qb4A-1im8A:
0.0		 2qb4A-1im8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1im8 YECO
(Haemophilus
influenzae) 		5 / 12 ASP A  61
LEU A  62
GLY A  63
ASP A  88
LEU A 137
 SAI  A 302 ( 4.8A)
None
SAI  A 302 (-3.8A)
SAI  A 302 (-2.8A)
None
 0.89A 3cjtC-1im8A:
15.4		 3cjtC-1im8A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1im8 YECO
(Haemophilus
influenzae) 		5 / 9 GLY A  86
ASP A  88
GLY A  63
VAL A  94
VAL A 120
 None
SAI  A 302 (-2.8A)
SAI  A 302 (-3.8A)
None
None
 1.27A 4c5lB-1im8A:
2.2		 4c5lB-1im8A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1im8 YECO
(Haemophilus
influenzae) 		5 / 10 GLY A  86
ASP A  88
GLY A  63
VAL A  94
VAL A 120
 None
SAI  A 302 (-2.8A)
SAI  A 302 (-3.8A)
None
None
 1.21A 4c5lC-1im8A:
undetectable		 4c5lC-1im8A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1im8 YECO
(Haemophilus
influenzae) 		5 / 10 GLY A  86
ASP A  88
GLY A  63
VAL A  94
VAL A 120
 None
SAI  A 302 (-2.8A)
SAI  A 302 (-3.8A)
None
None
 1.26A 4c5nB-1im8A:
3.1		 4c5nB-1im8A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1im8 YECO
(Haemophilus
influenzae) 		5 / 10 GLY A  86
ASP A  88
GLY A  63
VAL A  94
VAL A 120
 None
SAI  A 302 (-2.8A)
SAI  A 302 (-3.8A)
None
None
 1.23A 4c5nD-1im8A:
3.3		 4c5nD-1im8A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1im8 YECO
(Haemophilus
influenzae) 		6 / 12 GLY A  63
ASP A  88
MET A  93
ASP A 116
ILE A 117
LEU A 137
 SAI  A 302 (-3.8A)
SAI  A 302 (-2.8A)
SAI  A 302 (-4.1A)
SAI  A 302 (-3.1A)
SAI  A 302 (-4.1A)
None
 0.83A 4iv8A-1im8A:
18.1		 4iv8A-1im8A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1im8 YECO
(Haemophilus
influenzae) 		6 / 12 GLY A  63
ASP A  88
MET A  93
ASP A 116
ILE A 117
LEU A 137
 SAI  A 302 (-3.8A)
SAI  A 302 (-2.8A)
SAI  A 302 (-4.1A)
SAI  A 302 (-3.1A)
SAI  A 302 (-4.1A)
None
 0.87A 4iv8B-1im8A:
18.1		 4iv8B-1im8A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 1im8 YECO
(Haemophilus
influenzae) 		4 / 7 LEU A  62
LEU A 159
ILE A  41
ILE A  45
 None
 0.87A 4ojbA-1im8A:
undetectable		 4ojbA-1im8A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 1im8 YECO
(Haemophilus
influenzae) 		4 / 8 ILE A  42
ILE A  45
ASN A  76
ALA A  49
 None
 1.00A 4ou1A-1im8A:
undetectable		 4ou1A-1im8A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1im8 YECO
(Haemophilus
influenzae) 		3 / 3 LEU A 145
LEU A 130
ARG A 166
 None
 0.65A 5hnzB-1im8A:
3.1		 5hnzB-1im8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 1im8 YECO
(Haemophilus
influenzae) 		5 / 12 ASP A 116
ILE A 117
ARG A 118
LEU A 137
GLY A  63
 SAI  A 302 (-3.1A)
SAI  A 302 (-4.1A)
SAI  A 302 ( 4.5A)
None
SAI  A 302 (-3.8A)
 1.07A 5il1A-1im8A:
undetectable		 5il1A-1im8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 1im8 YECO
(Haemophilus
influenzae) 		3 / 3 PRO A 138
ARG A 118
GLU A 140
 None
SAI  A 302 ( 4.5A)
None
 0.97A 5j6hA-1im8A:
0.0		 5j6hA-1im8A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1im8 YECO
(Haemophilus
influenzae) 		5 / 12 ASP A 116
ILE A 117
ARG A 118
LEU A 137
GLY A  63
 SAI  A 302 (-3.1A)
SAI  A 302 (-4.1A)
SAI  A 302 ( 4.5A)
None
SAI  A 302 (-3.8A)
 1.13A 5k7uA-1im8A:
1.5		 5k7uA-1im8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1im8 YECO
(Haemophilus
influenzae) 		5 / 12 THR A 133
ALA A  68
GLY A  67
ALA A  69
ILE A  42
 SAI  A 302 ( 3.7A)
SAI  A 302 ( 4.0A)
None
SAI  A 302 ( 3.9A)
None
 0.87A 5kb6A-1im8A:
3.7		 5kb6A-1im8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 1im8 YECO
(Haemophilus
influenzae) 		4 / 8 ILE A 238
ILE A  41
ALA A  44
ILE A  45
 None
 0.74A 5mvmA-1im8A:
0.0
5mvmB-1im8A:
0.0		 5mvmA-1im8A:
14.75
5mvmB-1im8A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1im8 YECO
(Haemophilus
influenzae) 		4 / 6 ARG A 142
ARG A 118
ALA A 144
GLU A 140
 None
SAI  A 302 ( 4.5A)
None
None
 1.28A 5odqA-1im8A:
3.3		 5odqA-1im8A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 1im8 YECO
(Haemophilus
influenzae) 		3 / 3 LYS A 184
HIS A 180
HIS A 181
 None
 1.27A 5oexA-1im8A:
0.0		 5oexA-1im8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 1im8 YECO
(Haemophilus
influenzae) 		3 / 3 LYS A 184
HIS A 180
HIS A 181
 None
 1.23A 5oexB-1im8A:
0.0		 5oexB-1im8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 1im8 YECO
(Haemophilus
influenzae) 		3 / 3 LYS A 184
HIS A 180
HIS A 181
 None
 1.23A 5oexC-1im8A:
0.0		 5oexC-1im8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 1im8 YECO
(Haemophilus
influenzae) 		3 / 3 LYS A 184
HIS A 180
HIS A 181
 None
 1.23A 5oexD-1im8A:
0.0		 5oexD-1im8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1im8 YECO
(Haemophilus
influenzae) 		5 / 12 GLY A  46
ILE A  45
ILE A 108
VAL A 110
ILE A  77
 None
 0.76A 6emuB-1im8A:
undetectable		 6emuB-1im8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1im8 YECO
(Haemophilus
influenzae) 		5 / 12 GLY A  46
ILE A  45
ILE A 108
VAL A 110
ILE A  77
 None
 0.83A 6emuC-1im8A:
undetectable		 6emuC-1im8A:
21.29