SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1io0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 1io0 TROPOMODULIN
(Gallus
gallus) 		4 / 4 GLU A 185
ARG A 189
ASN A 192
ASP A 194
 None
 0.92A 2zq9A-1io0A:
undetectable		 2zq9A-1io0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 1io0 TROPOMODULIN
(Gallus
gallus) 		5 / 11 THR A 234
ILE A 264
ASN A 201
VAL A 273
LEU A 285
 None
 1.04A 3a51A-1io0A:
undetectable		 3a51A-1io0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 1io0 TROPOMODULIN
(Gallus
gallus) 		5 / 12 THR A 234
ILE A 264
ASN A 201
VAL A 273
LEU A 285
 None
 1.04A 3a51C-1io0A:
0.0		 3a51C-1io0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 1io0 TROPOMODULIN
(Gallus
gallus) 		5 / 12 THR A 234
ILE A 264
ASN A 201
VAL A 273
LEU A 285
 None
 1.03A 3a51D-1io0A:
0.0		 3a51D-1io0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 1io0 TROPOMODULIN
(Gallus
gallus) 		5 / 12 THR A 234
ILE A 264
ASN A 201
VAL A 273
LEU A 285
 None
 1.03A 3a51E-1io0A:
undetectable		 3a51E-1io0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1io0 TROPOMODULIN
(Gallus
gallus) 		3 / 3 PHE A 242
SER A 265
SER A 267
 None
 0.95A 3ufgB-1io0A:
0.0		 3ufgB-1io0A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1io0 TROPOMODULIN
(Gallus
gallus) 		5 / 12 ASP A 182
PRO A 209
ASN A 207
ILE A 205
VAL A 183
 None
 1.11A 4eb6B-1io0A:
undetectable
4eb6C-1io0A:
undetectable		 4eb6B-1io0A:
17.78
4eb6C-1io0A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1io0 TROPOMODULIN
(Gallus
gallus) 		4 / 8 ALA A 241
ASP A 288
ILE A 287
ILE A 302
 None
ZN  A1001 (-2.3A)
None
None
 0.83A 4kttB-1io0A:
0.0		 4kttB-1io0A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1io0 TROPOMODULIN
(Gallus
gallus) 		5 / 12 ILE A 231
LEU A 254
PHE A 229
THR A 186
ILE A 190
 None
 1.15A 4qleA-1io0A:
undetectable		 4qleA-1io0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1io0 TROPOMODULIN
(Gallus
gallus) 		5 / 12 ILE A 231
LEU A 254
PHE A 229
THR A 186
ILE A 190
 None
 1.12A 4x5hA-1io0A:
undetectable		 4x5hA-1io0A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 1io0 TROPOMODULIN
(Gallus
gallus) 		3 / 3 ASN A 203
SER A 230
ARG A 286
 None
 0.74A 5b2qA-1io0A:
undetectable		 5b2qA-1io0A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1io0 TROPOMODULIN
(Gallus
gallus) 		5 / 12 ILE A 231
LEU A 254
PHE A 229
THR A 186
ILE A 190
 None
 1.16A 5e8qB-1io0A:
undetectable		 5e8qB-1io0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1io0 TROPOMODULIN
(Gallus
gallus) 		5 / 12 ILE A 269
GLY A 268
GLU A 284
SER A 230
ILE A 231
 None
 1.23A 5igvA-1io0A:
undetectable		 5igvA-1io0A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1io0 TROPOMODULIN
(Gallus
gallus) 		5 / 12 ILE A 269
GLY A 268
GLU A 284
SER A 230
ILE A 231
 None
 1.12A 5igwA-1io0A:
0.0		 5igwA-1io0A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1io0 TROPOMODULIN
(Gallus
gallus) 		5 / 12 ILE A 231
LEU A 254
PHE A 229
THR A 186
ILE A 190
 None
 1.15A 5ujxB-1io0A:
undetectable		 5ujxB-1io0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1io0 TROPOMODULIN
(Gallus
gallus) 		4 / 5 LEU A 213
LYS A 214
ALA A 217
LEU A 220
 None
 0.83A 5vkqA-1io0A:
0.1
5vkqD-1io0A:
0.0		 5vkqA-1io0A:
7.67
5vkqD-1io0A:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1io0 TROPOMODULIN
(Gallus
gallus) 		4 / 5 LEU A 213
LYS A 214
ALA A 217
LEU A 220
 None
 0.82A 5vkqA-1io0A:
0.1
5vkqB-1io0A:
0.2		 5vkqA-1io0A:
7.67
5vkqB-1io0A:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1io0 TROPOMODULIN
(Gallus
gallus) 		4 / 5 LEU A 213
LYS A 214
ALA A 217
LEU A 220
 None
 0.81A 5vkqB-1io0A:
0.2
5vkqC-1io0A:
0.1		 5vkqB-1io0A:
7.67
5vkqC-1io0A:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1io0 TROPOMODULIN
(Gallus
gallus) 		4 / 5 LEU A 213
LYS A 214
ALA A 217
LEU A 220
 None
 0.83A 5vkqC-1io0A:
0.1
5vkqD-1io0A:
0.0		 5vkqC-1io0A:
7.67
5vkqD-1io0A:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1io0 TROPOMODULIN
(Gallus
gallus) 		5 / 12 ILE A 231
LEU A 254
PHE A 229
THR A 186
ILE A 190
 None
 1.25A 5z6fA-1io0A:
undetectable		 5z6fA-1io0A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1io0 TROPOMODULIN
(Gallus
gallus) 		4 / 6 ARG A 327
ALA A 303
LEU A 306
ALA A 331
 None
 1.07A 6fosB-1io0A:
undetectable		 6fosB-1io0A:
19.05