SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1io1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 1io1 PHASE 1 FLAGELLIN
(Salmonella
enterica) 		4 / 7 PHE A 432
SER A  64
ALA A 435
ILE A 436
 None
 0.99A 1fxhA-1io1A:
0.0
1fxhB-1io1A:
0.0		 1fxhA-1io1A:
19.60
1fxhB-1io1A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 1io1 PHASE 1 FLAGELLIN
(Salmonella
enterica) 		5 / 12 GLY A 227
ASP A 224
ASP A 277
PRO A 271
LEU A 270
 None
 0.99A 2hmyB-1io1A:
undetectable		 2hmyB-1io1A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 1io1 PHASE 1 FLAGELLIN
(Salmonella
enterica) 		4 / 6 TYR A 229
VAL A 278
THR A 226
THR A 225
 None
 1.08A 3tneA-1io1A:
undetectable		 3tneA-1io1A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 1io1 PHASE 1 FLAGELLIN
(Salmonella
enterica) 		3 / 3 ASP A 419
ARG A 422
ASP A 412
 None
 0.81A 4fp9A-1io1A:
undetectable		 4fp9A-1io1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 1io1 PHASE 1 FLAGELLIN
(Salmonella
enterica) 		3 / 3 ASP A 419
ARG A 422
ASP A 412
 None
 0.80A 4fp9C-1io1A:
undetectable		 4fp9C-1io1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 1io1 PHASE 1 FLAGELLIN
(Salmonella
enterica) 		3 / 3 ASP A 419
ARG A 422
ASP A 412
 None
 0.77A 4fp9F-1io1A:
undetectable		 4fp9F-1io1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1io1 PHASE 1 FLAGELLIN
(Salmonella
enterica) 		4 / 6 GLU A 290
GLY A 328
ASP A 330
GLY A 302
 None
 0.88A 5cdnA-1io1A:
2.4
5cdnB-1io1A:
undetectable		 5cdnA-1io1A:
21.50
5cdnB-1io1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1io1 PHASE 1 FLAGELLIN
(Salmonella
enterica) 		4 / 6 GLU A 290
GLY A 328
ASP A 330
GLY A 302
 None
 0.92A 5cdnR-1io1A:
2.4
5cdnS-1io1A:
undetectable		 5cdnR-1io1A:
21.50
5cdnS-1io1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1io1 PHASE 1 FLAGELLIN
(Salmonella
enterica) 		4 / 6 GLU A 290
GLY A 328
ASP A 330
GLY A 302
 None
 0.92A 5cdnC-1io1A:
undetectable
5cdnD-1io1A:
undetectable		 5cdnC-1io1A:
21.50
5cdnD-1io1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1io1 PHASE 1 FLAGELLIN
(Salmonella
enterica) 		4 / 6 GLU A 290
GLY A 328
ASP A 330
GLY A 302
 None
 0.92A 5cdnT-1io1A:
2.4
5cdnU-1io1A:
undetectable		 5cdnT-1io1A:
21.50
5cdnU-1io1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_B_GLYB404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 1io1 PHASE 1 FLAGELLIN
(Salmonella
enterica) 		4 / 4 GLN A 429
ALA A  74
GLN A  75
THR A  77
 None
 1.30A 5hhjB-1io1A:
0.0		 5hhjB-1io1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1io1 PHASE 1 FLAGELLIN
(Salmonella
enterica) 		4 / 6 ASP A 412
ASP A 170
ASN A 163
GLN A 417
 None
 1.24A 5l6eA-1io1A:
undetectable		 5l6eA-1io1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1io1 PHASE 1 FLAGELLIN
(Salmonella
enterica) 		5 / 10 ILE A  73
ILE A 157
VAL A 428
PHE A 432
ALA A 435
 None
 1.16A 5nukA-1io1A:
0.0		 5nukA-1io1A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 1io1 PHASE 1 FLAGELLIN
(Salmonella
enterica) 		4 / 6 ASN A 285
ALA A 284
VAL A 187
TYR A 190
 None
 1.22A 5umd2-1io1A:
0.0
5umdF-1io1A:
0.0		 5umd2-1io1A:
13.45
5umdF-1io1A:
10.99