SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1io3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NXU_B_RITB600_2 (CYTOCHROME P450 3A4)	1io3	CYTOCHROME C2 (Blastochloris viridis)	5 / 9	ARG A 64 ILE A 67 LEU A 34 GLU A 61 GLY A 36	None None HEM A 108 ( 4.8A) None None	1.03A	3nxuB-1io3A: undetectable	3nxuB-1io3A: 13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OKX_B_SAMB201_0 (YAEB-LIKE PROTEIN RPA0152)	1io3	CYTOCHROME C2 (Blastochloris viridis)	3 / 3	LYS A 73 ARG A 68 LYS A 98	None	1.43A	3okxA-1io3A: undetectable	3okxA-1io3A: 19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J7X_B_SASB804_1 (SEPIAPTERIN REDUCTASE)	1io3	CYTOCHROME C2 (Blastochloris viridis)	5 / 12	CYH A 13 PHE A 10 PRO A 29 GLY A 33 LEU A 34	HEM A 108 (-1.7A) None HEM A 108 (-4.8A) None HEM A 108 ( 4.8A)	1.28A	4j7xB-1io3A: undetectable	4j7xB-1io3A: 16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GTR_A_ESTA601_2 (ESTROGEN RECEPTOR)	1io3	CYTOCHROME C2 (Blastochloris viridis)	4 / 5	LEU A 34 PHE A 35 LEU A 93 HIS A 17	HEM A 108 ( 4.8A) None None HEM A 108 (-3.1A)	1.05A	5gtrA-1io3A: undetectable	5gtrA-1io3A: 21.56

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3NXU_B_RITB600_2","CYTOCHROME P450 3A4","1io3","CYTOCHROME C2","Blastochloris viridis",5,"ARG A  64;ILE A  67;LEU A  34;GLU A  61;GLY A  36","None;None;HEM A 108 ( 4.8A);None;None","1.03A","3nxuB-1io3A:undetectable","3nxuB-1io3A:13.74"],["3OKX_B_SAMB201_0","YAEB-LIKE PROTEIN RPA0152","1io3","CYTOCHROME C2","Blastochloris viridis",3,"LYS A  73;ARG A  68;LYS A  98","None","1.43A","3okxA-1io3A:undetectable","3okxA-1io3A:19.88"],["4J7X_B_SASB804_1","SEPIAPTERIN REDUCTASE","1io3","CYTOCHROME C2","Blastochloris viridis",5,"CYH A  13;PHE A  10;PRO A  29;GLY A  33;LEU A  34","HEM A 108 (-1.7A);None;HEM A 108 (-4.8A);None;HEM A 108 ( 4.8A)","1.28A","4j7xB-1io3A:undetectable","4j7xB-1io3A:16.15"],["5GTR_A_ESTA601_2","ESTROGEN RECEPTOR","1io3","CYTOCHROME C2","Blastochloris viridis",4,"LEU A  34;PHE A  35;LEU A  93;HIS A  17","HEM A 108 ( 4.8A);None;None;HEM A 108 (-3.1A)","1.05A","5gtrA-1io3A:undetectable","5gtrA-1io3A:21.56"]]