SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ioa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1ioa ARCELIN-5A
(Phaseolus
vulgaris) 		5 / 12 GLY A  48
LEU A  31
VAL A 218
LEU A  87
ALA A  88
 None
 1.01A 1gseB-1ioaA:
undetectable		 1gseB-1ioaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1ioa ARCELIN-5A
(Phaseolus
vulgaris) 		5 / 12 PHE A  89
LEU A 190
ASP A 132
VAL A 142
VAL A 184
 None
 1.08A 3dmhA-1ioaA:
undetectable		 3dmhA-1ioaA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ioa ARCELIN-5A
(Phaseolus
vulgaris) 		4 / 6 ILE A 160
LYS A 181
PHE A 175
PHE A  73
 None
 1.08A 3elzB-1ioaA:
0.2		 3elzB-1ioaA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 1ioa ARCELIN-5A
(Phaseolus
vulgaris) 		5 / 10 THR A 205
GLY A 207
PHE A 127
GLU A 214
LEU A 208
 None
 1.31A 3kvrA-1ioaA:
undetectable		 3kvrA-1ioaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1ioa ARCELIN-5A
(Phaseolus
vulgaris) 		5 / 10 THR A 205
GLY A 207
PHE A 127
GLU A 214
LEU A 208
 None
 1.30A 3kvrB-1ioaA:
undetectable		 3kvrB-1ioaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 1ioa ARCELIN-5A
(Phaseolus
vulgaris) 		5 / 11 ILE A 107
PHE A 108
ALA A  88
VAL A  92
PRO A  93
 None
 1.08A 3tmzA-1ioaA:
undetectable		 3tmzA-1ioaA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ioa ARCELIN-5A
(Phaseolus
vulgaris) 		5 / 11 PHE A 223
LEU A 190
VAL A 188
PHE A 133
VAL A 120
 None
 1.46A 3u9fN-1ioaA:
0.0
3u9fO-1ioaA:
0.0		 3u9fN-1ioaA:
19.70
3u9fO-1ioaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ioa ARCELIN-5A
(Phaseolus
vulgaris) 		5 / 9 PHE A 223
LEU A 190
VAL A 188
PHE A 133
VAL A 120
 None
 1.47A 3u9fP-1ioaA:
0.0		 3u9fP-1ioaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1ioa ARCELIN-5A
(Phaseolus
vulgaris) 		5 / 12 PHE A  67
GLY A 201
ILE A  56
VAL A 198
ALA A  88
 None
 0.99A 4a6dA-1ioaA:
undetectable		 4a6dA-1ioaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1ioa ARCELIN-5A
(Phaseolus
vulgaris) 		5 / 12 PHE A  67
GLY A 201
ILE A  56
VAL A 198
ALA A  88
 None
 1.00A 4a6eA-1ioaA:
undetectable		 4a6eA-1ioaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 1ioa ARCELIN-5A
(Phaseolus
vulgaris) 		5 / 9 PHE A  11
LEU A  17
LEU A  87
THR A  72
PHE A  89
 None
 1.45A 4wnvB-1ioaA:
0.0		 4wnvB-1ioaA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1ioa ARCELIN-5A
(Phaseolus
vulgaris) 		5 / 12 ASP A 134
THR A 156
PRO A 204
GLY A  86
LEU A  87
 None
 1.40A 5m50B-1ioaA:
undetectable		 5m50B-1ioaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1ioa ARCELIN-5A
(Phaseolus
vulgaris) 		5 / 12 ASP A 134
PHE A  71
THR A 156
GLY A  86
LEU A  87
 None
 1.07A 5m54E-1ioaA:
undetectable		 5m54E-1ioaA:
22.41