SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iok'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		4 / 6 LYS A 322
LYS A 321
ALA A 320
VAL A 190
 None
 1.04A 1hk1A-1iokA:
2.1		 1hk1A-1iokA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		5 / 8 THR A  90
GLY A  53
GLY A  32
LEU A  31
GLY A  35
 None
 1.30A 1jhvA-1iokA:
undetectable		 1jhvA-1iokA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		5 / 11 ALA A 441
GLU A 448
ARG A 470
ARG A 452
ALA A  98
 None
 1.30A 1mjlA-1iokA:
undetectable
1mjlB-1iokA:
0.5		 1mjlA-1iokA:
11.75
1mjlB-1iokA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		5 / 10 LEU A 447
VAL A 420
GLY A 422
VAL A 412
VAL A 413
 None
 1.20A 2cp4A-1iokA:
undetectable		 2cp4A-1iokA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		4 / 8 GLY A 154
ALA A 152
THR A 403
ILE A 158
 None
 0.85A 2dtjA-1iokA:
undetectable
2dtjB-1iokA:
undetectable		 2dtjA-1iokA:
15.57
2dtjB-1iokA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		5 / 9 THR A  91
LEU A  95
THR A 124
ILE A 131
VAL A 128
 None
 1.50A 2l8mA-1iokA:
0.0		 2l8mA-1iokA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		4 / 7 LEU A  31
THR A  90
VAL A 500
ASP A 496
 None
 0.98A 2qblA-1iokA:
0.0		 2qblA-1iokA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		5 / 12 LEU A 247
ASP A 217
THR A 296
GLY A 318
GLY A 298
 None
 1.06A 2uvnA-1iokA:
0.0		 2uvnA-1iokA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		3 / 3 MET A 183
VAL A 177
GLU A 391
 None
 0.71A 2x9gA-1iokA:
undetectable		 2x9gA-1iokA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		5 / 12 VAL A 107
LEU A 104
GLY A 103
ILE A  99
THR A 517
 None
 1.13A 3bjwF-1iokA:
undetectable		 3bjwF-1iokA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		4 / 5 PRO A 497
VAL A 500
THR A  30
GLY A  53
 None
 1.10A 3elzB-1iokA:
undetectable		 3elzB-1iokA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		4 / 6 HIS A 223
LEU A 227
LYS A 277
ALA A 275
 None
 1.26A 3gv1A-1iokA:
0.0
3gv1C-1iokA:
0.0		 3gv1A-1iokA:
13.11
3gv1C-1iokA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		5 / 6 ALA A 106
ILE A 516
LEU A 116
GLU A 102
ALA A 441
 None
 1.37A 3r9sA-1iokA:
undetectable		 3r9sA-1iokA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		5 / 12 ILE A 162
GLY A 148
GLY A 159
ARG A 395
GLY A 154
 None
 0.92A 3uboA-1iokA:
undetectable		 3uboA-1iokA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		4 / 4 ASP A 507
THR A  89
VAL A 511
SER A  79
 None
 1.18A 3wxoA-1iokA:
0.0		 3wxoA-1iokA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		5 / 9 THR A  90
GLY A  53
GLY A  32
LEU A  31
GLY A  35
 None
 1.33A 4kqiA-1iokA:
undetectable		 4kqiA-1iokA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		5 / 11 ALA A 320
ASP A 334
ILE A 294
THR A 330
VAL A 323
 None
 0.93A 4l1aA-1iokA:
undetectable		 4l1aA-1iokA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		5 / 12 TYR A 199
TYR A 203
SER A 324
ALA A 218
ALA A 274
 None
 1.34A 4ymgA-1iokA:
0.0		 4ymgA-1iokA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		5 / 12 TYR A 199
TYR A 203
SER A 324
ALA A 218
ALA A 274
 None
 1.39A 4ymgB-1iokA:
undetectable		 4ymgB-1iokA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		4 / 7 GLU A 519
ARG A  13
ASP A  14
ALA A  12
 None
 1.12A 4zz8A-1iokA:
0.0		 4zz8A-1iokA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		4 / 8 ILE A 162
ALA A 163
VAL A 138
VAL A 407
 None
 0.39A 5l94A-1iokA:
undetectable		 5l94A-1iokA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		3 / 3 THR A 124
PRO A 450
ARG A 452
 None
 0.54A 5nd7B-1iokA:
undetectable		 5nd7B-1iokA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		4 / 7 MET A 384
VAL A 381
PHE A 157
GLU A 388
 None
 1.09A 5unxA-1iokA:
0.0
5unxB-1iokA:
0.0		 5unxA-1iokA:
22.85
5unxB-1iokA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		4 / 5 ASN A 401
ASP A 398
ASP A  52
ASN A  82
 None
 0.94A 5vooA-1iokA:
undetectable		 5vooA-1iokA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		4 / 5 ASN A 401
ASP A 398
ASP A  52
ASN A  82
 None
 0.93A 5vooC-1iokA:
undetectable		 5vooC-1iokA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		3 / 3 ALA A 481
VAL A 469
TYR A 486
 None
 0.64A 5zmqH-1iokA:
undetectable		 5zmqH-1iokA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		5 / 9 VAL A  77
VAL A 100
GLY A  19
LEU A  23
GLN A  97
 None
 1.22A 6czmB-1iokA:
1.2
6czmC-1iokA:
0.0		 6czmB-1iokA:
25.00
6czmC-1iokA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 1iok CHAPERONIN 60
(Paracoccus
denitrificans) 		3 / 3 LYS A  28
VAL A  94
ASP A  25
 None
 0.70A 6fgdA-1iokA:
undetectable		 6fgdA-1iokA:
22.24