SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iom'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		3 / 3 ALA A 248
VAL A 243
TRP A 242
 None
 0.79A 1kqeA-1iomA:
undetectable
1kqeE-1iomA:
undetectable		 1kqeA-1iomA:
2.50
1kqeE-1iomA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		3 / 3 ALA A 248
VAL A 243
TRP A 242
 None
 0.77A 1kqeB-1iomA:
undetectable
1kqeD-1iomA:
undetectable		 1kqeB-1iomA:
2.50
1kqeD-1iomA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		3 / 3 TRP A 242
ALA A 248
VAL A 243
 None
 0.79A 1kqeB-1iomA:
undetectable
1kqeD-1iomA:
undetectable		 1kqeB-1iomA:
2.50
1kqeD-1iomA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		3 / 3 TRP A 242
ALA A 248
VAL A 243
 None
 0.78A 1kqeA-1iomA:
undetectable
1kqeE-1iomA:
undetectable		 1kqeA-1iomA:
2.50
1kqeE-1iomA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 HIS A 153
ALA A 133
VAL A 335
ALA A 334
PHE A 324
 None
 1.32A 1udtA-1iomA:
0.7		 1udtA-1iomA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		5 / 10 HIS A 153
ALA A 182
THR A  47
ILE A 179
SER A 339
 None
 1.33A 1utdQ-1iomA:
undetectable
1utdR-1iomA:
undetectable		 1utdQ-1iomA:
11.08
1utdR-1iomA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		4 / 4 PHE A 157
ASP A 175
PHE A  43
VAL A 335
 None
 1.01A 1w0fA-1iomA:
0.3		 1w0fA-1iomA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		4 / 8 ASP A 123
LYS A 127
PHE A  43
THR A  46
 None
 0.93A 2aouA-1iomA:
undetectable		 2aouA-1iomA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		4 / 7 GLN A  35
ILE A  20
TYR A  29
CYH A  18
 None
 1.38A 2xz5D-1iomA:
0.0
2xz5E-1iomA:
0.0		 2xz5D-1iomA:
18.16
2xz5E-1iomA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		3 / 3 TYR A  30
GLU A 347
THR A 190
 None
 1.01A 2y7hB-1iomA:
undetectable		 2y7hB-1iomA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		3 / 3 MET A  92
GLU A 224
ASP A 312
 None
None
GOL  A 400 (-2.9A)
 1.08A 3a25A-1iomA:
undetectable		 3a25A-1iomA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APT_B_ACTB311_0
(METHYLENETETRAHYDROF
OLATE REDUCTASE)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		5 / 9 HIS A 258
ASP A 265
PRO A 266
ILE A  20
HIS A 184
 GOL  A 400 (-3.9A)
None
None
None
CO3  A 500 (-4.0A)
 1.17A 3aptB-1iomA:
undetectable		 3aptB-1iomA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		4 / 7 LEU A  55
GLU A  45
PRO A  33
ILE A  32
 None
 0.95A 3s56B-1iomA:
undetectable		 3s56B-1iomA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		5 / 9 GLY A 255
PRO A 309
GLU A 296
GLY A 299
TYR A 308
 None
 1.32A 4fimA-1iomA:
undetectable		 4fimA-1iomA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A 203
ALA A 193
ILE A 125
LEU A 124
GLY A 343
 None
 0.75A 4nkvB-1iomA:
0.0		 4nkvB-1iomA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		4 / 4 THR A  47
GLY A 121
ASP A 123
SER A 339
 None
 1.17A 4rfqA-1iomA:
undetectable		 4rfqA-1iomA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		4 / 5 PHE A 157
ASP A 175
PHE A  43
VAL A 335
 None
 1.09A 5a1rA-1iomA:
undetectable		 5a1rA-1iomA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		5 / 11 TYR A 314
VAL A 226
ILE A 230
ILE A 293
ILE A 307
 None
 1.15A 5hw8A-1iomA:
undetectable
5hw8D-1iomA:
undetectable		 5hw8A-1iomA:
16.44
5hw8D-1iomA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		4 / 5 HIS A 184
ARG A 267
PHE A 333
ARG A 337
 CO3  A 500 (-4.0A)
GOL  A 400 (-2.9A)
GOL  A 400 ( 4.8A)
CO3  A 500 (-3.0A)
 0.62A 6hxiB-1iomA:
14.5		 6hxiB-1iomA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 1iom CITRATE SYNTHASE
(Thermus
thermophilus) 		4 / 5 HIS A 184
ARG A 267
PHE A 333
ARG A 337
 CO3  A 500 (-4.0A)
GOL  A 400 (-2.9A)
GOL  A 400 ( 4.8A)
CO3  A 500 (-3.0A)
 0.62A 6hxiD-1iomA:
16.1		 6hxiD-1iomA:
23.84