SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ioo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 1ioo SF11-RNASE
(Nicotiana
alata) 		3 / 3 ASP A 113
ASP A 116
ASP A  62
 NAG  A 198 ( 3.5A)
NAG  A 197 (-3.7A)
XYP  A 200 ( 4.6A)
 0.72A 1eizA-1iooA:
undetectable		 1eizA-1iooA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 1ioo SF11-RNASE
(Nicotiana
alata) 		3 / 3 ASP A 113
ASP A 116
ASP A  62
 NAG  A 198 ( 3.5A)
NAG  A 197 (-3.7A)
XYP  A 200 ( 4.6A)
 0.69A 1ej0A-1iooA:
undetectable		 1ej0A-1iooA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1ioo SF11-RNASE
(Nicotiana
alata) 		3 / 3 ASP A 113
ASP A 116
ASP A  62
 NAG  A 198 ( 3.5A)
NAG  A 197 (-3.7A)
XYP  A 200 ( 4.6A)
 0.76A 3douA-1iooA:
undetectable		 3douA-1iooA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1ioo SF11-RNASE
(Nicotiana
alata) 		4 / 6 LEU A 193
GLU A 162
PRO A 161
ARG A 195
 None
 1.16A 3ltwA-1iooA:
undetectable		 3ltwA-1iooA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1ioo SF11-RNASE
(Nicotiana
alata) 		4 / 4 PHE A  29
TYR A 164
LEU A 111
LYS A 112
 None
None
None
NAG  A 197 (-2.9A)
 1.24A 3sudC-1iooA:
0.0		 3sudC-1iooA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1ioo SF11-RNASE
(Nicotiana
alata) 		4 / 5 PHE A  29
TYR A 164
LEU A 111
LYS A 112
 None
None
None
NAG  A 197 (-2.9A)
 1.09A 3sudD-1iooA:
0.0		 3sudD-1iooA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1ioo SF11-RNASE
(Nicotiana
alata) 		4 / 5 PHE A  29
TYR A 164
LEU A 111
LYS A 112
 None
None
None
NAG  A 197 (-2.9A)
 1.35A 3sueC-1iooA:
undetectable		 3sueC-1iooA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1ioo SF11-RNASE
(Nicotiana
alata) 		4 / 5 PHE A  29
TYR A 164
LEU A 111
LYS A 112
 None
None
None
NAG  A 197 (-2.9A)
 1.22A 3sugA-1iooA:
0.0		 3sugA-1iooA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1ioo SF11-RNASE
(Nicotiana
alata) 		3 / 3 ASN A 173
LEU A  34
PHE A 178
 None
 0.66A 4dajB-1iooA:
undetectable		 4dajB-1iooA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1ioo SF11-RNASE
(Nicotiana
alata) 		4 / 5 PHE A 194
HIS A 124
LEU A 117
PRO A 128
 None
 1.49A 5csyB-1iooA:
undetectable		 5csyB-1iooA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1ioo SF11-RNASE
(Nicotiana
alata) 		3 / 3 ASN A 173
LEU A  34
PHE A 178
 None
 0.80A 5dsgA-1iooA:
undetectable		 5dsgA-1iooA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1ioo SF11-RNASE
(Nicotiana
alata) 		3 / 3 ASN A 173
LEU A 111
PHE A 178
 None
 0.76A 5dsgA-1iooA:
undetectable		 5dsgA-1iooA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 1ioo SF11-RNASE
(Nicotiana
alata) 		4 / 7 VAL A 144
PHE A 134
PHE A  29
LEU A 163
 None
 1.18A 6aycA-1iooA:
0.0		 6aycA-1iooA:
16.75