SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iou'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RMT_C_ADNC1503_1 (CLASS B ACID PHOSPHATASE)	1iou	YKT6P (Saccharomyces cerevisiae)	4 / 8	ASP A 112 TYR A 101 LEU A 19 GLY A 12	None	0.93A	1rmtC-1iouA: undetectable	1rmtC-1iouA: 21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VQ1_B_SAMB301_0 (N5-GLUTAMINE METHYLTRANSFERASE, HEMK)	1iou	YKT6P (Saccharomyces cerevisiae)	6 / 12	THR A 116 GLY A 77 GLY A 7 VAL A 68 GLU A 55 ALA A 44	None	1.44A	1vq1B-1iouA: undetectable	1vq1B-1iouA: 18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T7V_A_SAMA992_0 (METHYLORNITHINE SYNTHASE PYLB)	1iou	YKT6P (Saccharomyces cerevisiae)	5 / 12	GLY A 52 GLY A 54 TYR A 69 VAL A 47 ALA A 44	None	1.24A	3t7vA-1iouA: undetectable	3t7vA-1iouA: 18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGZ_B_CQAB302_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	1iou	YKT6P (Saccharomyces cerevisiae)	4 / 8	GLU A 45 GLU A 18 ARG A 10 GLY A 13	None	0.85A	4fgzA-1iouA: undetectable 4fgzB-1iouA: undetectable	4fgzA-1iouA: 21.77 4fgzB-1iouA: 21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_1_BEZ1801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	1iou	YKT6P (Saccharomyces cerevisiae)	3 / 3	LEU A 79 PHE A 9 ILE A 80	None	0.74A	5dzk1-1iouA: undetectable 5dzkF-1iouA: undetectable 5dzkM-1iouA: 0.0	5dzk1-1iouA: 2.13 5dzkF-1iouA: 20.00 5dzkM-1iouA: 20.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RMT_C_ADNC1503_1","CLASS B ACID PHOSPHATASE","1iou","YKT6P","Saccharomyces cerevisiae",4,"ASP A 112;TYR A 101;LEU A  19;GLY A  12","None","0.93A","1rmtC-1iouA:undetectable","1rmtC-1iouA:21.78"],["1VQ1_B_SAMB301_0","N5-GLUTAMINE METHYLTRANSFERASE, HEMK","1iou","YKT6P","Saccharomyces cerevisiae",6,"THR A 116;GLY A  77;GLY A   7;VAL A  68;GLU A  55;ALA A  44","None","1.44A","1vq1B-1iouA:undetectable","1vq1B-1iouA:18.31"],["3T7V_A_SAMA992_0","METHYLORNITHINE SYNTHASE PYLB","1iou","YKT6P","Saccharomyces cerevisiae",5,"GLY A  52;GLY A  54;TYR A  69;VAL A  47;ALA A  44","None","1.24A","3t7vA-1iouA:undetectable","3t7vA-1iouA:18.21"],["4FGZ_B_CQAB302_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE","1iou","YKT6P","Saccharomyces cerevisiae",4,"GLU A  45;GLU A  18;ARG A  10;GLY A  13","None","0.85A","4fgzA-1iouA:undetectable;4fgzB-1iouA:undetectable","4fgzA-1iouA:21.77;4fgzB-1iouA:21.77"],["5DZK_1_BEZ1801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1;ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","1iou","YKT6P","Saccharomyces cerevisiae",3,"LEU A  79;PHE A   9;ILE A  80","None","0.74A","5dzk1-1iouA:undetectable;5dzkF-1iouA:undetectable;5dzkM-1iouA:0.0","5dzk1-1iouA:2.13;5dzkF-1iouA:20.00;5dzkM-1iouA:20.50"]]