SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iov'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		4 / 6 LEU A 248
LYS A 251
VAL A  58
MET A  95
 None
 0.96A 1opjB-1iovA:
undetectable		 1opjB-1iovA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		3 / 3 ARG A 288
VAL A 298
GLY A  23
 None
 0.65A 2avvE-1iovA:
undetectable		 2avvE-1iovA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		4 / 6 LEU A 248
LYS A 251
VAL A  58
MET A  95
 None
 0.98A 2hyyB-1iovA:
undetectable		 2hyyB-1iovA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		4 / 6 LEU A 248
LYS A 251
VAL A  58
MET A  95
 None
 0.93A 2hyyC-1iovA:
undetectable		 2hyyC-1iovA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		4 / 5 LEU A 248
VAL A  58
LEU A   8
MET A  95
 None
 0.95A 2oiqA-1iovA:
undetectable		 2oiqA-1iovA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		5 / 9 GLY A  85
SER A  22
SER A  19
GLU A  68
LEU A  62
 None
None
None
POB  A 321 ( 4.8A)
None
 1.11A 3ai9X-1iovA:
2.2		 3ai9X-1iovA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		4 / 6 LEU A 248
LYS A 251
VAL A  58
MET A  95
 None
 0.97A 3k5vA-1iovA:
undetectable		 3k5vA-1iovA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		5 / 12 LEU A 248
VAL A 111
LEU A 268
ALA A 107
LEU A 103
 None
 1.04A 4o1zB-1iovA:
0.0		 4o1zB-1iovA:
19.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		4 / 6 LYS A 215
ARG A 255
GLY A 276
LEU A 282
 POB  A 321 (-2.5A)
POB  A 321 (-3.2A)
POB  A 321 (-3.2A)
POB  A 321 (-3.7A)
 0.90A 5bphA-1iovA:
18.3		 5bphA-1iovA:
73.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		5 / 6 TYR A 210
LYS A 215
GLY A 276
SER A 281
LEU A 282
 None
POB  A 321 (-2.5A)
POB  A 321 (-3.2A)
POB  A 321 ( 2.2A)
POB  A 321 (-3.7A)
 0.77A 5bphA-1iovA:
18.3		 5bphA-1iovA:
73.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BPH_B_ACTB403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		5 / 5 LYS A 215
TYR A 216
ARG A 255
ASN A 272
GLY A 276
 POB  A 321 (-2.5A)
None
POB  A 321 (-3.2A)
MG  A 331 (-2.8A)
POB  A 321 (-3.2A)
 0.97A 5bphB-1iovA:
18.3		 5bphB-1iovA:
73.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		7 / 7 TYR A 210
LYS A 215
TYR A 216
ARG A 255
GLY A 276
SER A 281
LEU A 282
 None
POB  A 321 (-2.5A)
None
POB  A 321 (-3.2A)
POB  A 321 (-3.2A)
POB  A 321 ( 2.2A)
POB  A 321 (-3.7A)
 0.79A 5bphB-1iovA:
18.3		 5bphB-1iovA:
73.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		4 / 4 TYR A 210
GLY A 276
SER A 281
LEU A 282
 None
POB  A 321 (-3.2A)
POB  A 321 ( 2.2A)
POB  A 321 (-3.7A)
 0.76A 5bphC-1iovA:
24.3		 5bphC-1iovA:
73.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		6 / 6 TYR A 210
LYS A 215
ARG A 255
GLY A 276
SER A 281
LEU A 282
 None
POB  A 321 (-2.5A)
POB  A 321 (-3.2A)
POB  A 321 (-3.2A)
POB  A 321 ( 2.2A)
POB  A 321 (-3.7A)
 0.83A 5bphD-1iovA:
42.4		 5bphD-1iovA:
73.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BPH_D_ACTD406_0
(D-ALANINE--D-ALANINE
LIGASE)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		4 / 4 LYS A 215
ARG A 255
ASN A 272
GLY A 276
 POB  A 321 (-2.5A)
POB  A 321 (-3.2A)
MG  A 331 (-2.8A)
POB  A 321 (-3.2A)
 1.10A 5bphD-1iovA:
42.4		 5bphD-1iovA:
73.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		5 / 12 GLY A  11
ASP A  46
VAL A  47
THR A  48
LEU A  72
 None
 1.08A 5kocA-1iovA:
undetectable		 5kocA-1iovA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		5 / 10 LEU A  27
GLY A  29
LEU A   9
SER A  19
VAL A   7
 None
 1.15A 5twjB-1iovA:
undetectable		 5twjB-1iovA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		5 / 12 LEU A  27
GLY A  29
LEU A   9
SER A  19
VAL A   7
 None
 1.09A 5twjC-1iovA:
undetectable		 5twjC-1iovA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		3 / 3 PHE A 188
ASP A 257
LEU A 193
 None
MG  A 330 (-2.8A)
None
 0.79A 5uhcC-1iovA:
0.0		 5uhcC-1iovA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		5 / 10 LEU A  30
LEU A  50
LEU A  62
ALA A  61
LEU A   9
 None
 1.26A 5y7pB-1iovA:
0.0		 5y7pB-1iovA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		6 / 12 SER A 274
THR A 273
GLY A 252
SER A  86
PHE A  59
VAL A  26
 None
 1.38A 6a94B-1iovA:
0.0		 6a94B-1iovA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		4 / 8 GLY A  11
LEU A  72
GLY A  67
LEU A  62
 None
 0.73A 6mdqA-1iovA:
0.4		 6mdqA-1iovA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1iov D-ALA:D-ALA LIGASE
(Escherichia
coli) 		4 / 7 ASP A  69
ARG A 147
ASP A 174
GLU A 175
 None
 1.26A 6mn5E-1iovA:
0.0		 6mn5E-1iovA:
18.11