SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ipa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A 215
MET A 237
SER A 243
LEU A 244
VAL A 246
 None
 0.72A 1v2xA-1ipaA:
18.8		 1v2xA-1ipaA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ILE A 235
MET A 237
SER A 243
LEU A 244
VAL A 246
 None
 0.45A 1v2xA-1ipaA:
18.8		 1v2xA-1ipaA:
26.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 11 THR A 193
GLY A 215
GLY A 220
MET A 237
SER A 243
LEU A 244
 None
 1.21A 1x7pA-1ipaA:
21.9
1x7pB-1ipaA:
22.3		 1x7pA-1ipaA:
31.89
1x7pB-1ipaA:
31.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 THR A 193
GLY A 215
GLY A 220
MET A 237
LEU A 244
 None
 0.77A 1x7pA-1ipaA:
21.9
1x7pB-1ipaA:
22.3		 1x7pA-1ipaA:
31.89
1x7pB-1ipaA:
31.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ARG A  20
VAL A 147
GLY A 149
LEU A 130
SER A 155
 None
 1.36A 2bxeA-1ipaA:
undetectable		 2bxeA-1ipaA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A  74
LEU A  96
ALA A  34
ILE A  37
ALA A  67
 None
 1.03A 2bxpA-1ipaA:
undetectable		 2bxpA-1ipaA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 THR A 193
GLY A 215
GLY A 220
LEU A 244
VAL A 246
 None
 0.86A 3dcmX-1ipaA:
13.3		 3dcmX-1ipaA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ALA A  43
VAL A 165
GLY A 164
ALA A 100
ILE A  45
 None
 0.94A 3ekwB-1ipaA:
undetectable		 3ekwB-1ipaA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		7 / 11 GLY A 215
ILE A 235
MET A 237
SER A 243
LEU A 244
VAL A 246
SER A 249
 None
 0.85A 3gyqB-1ipaA:
19.1		 3gyqB-1ipaA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		8 / 12 ASN A 129
GLY A 215
ILE A 235
MET A 237
SER A 243
ASN A 245
VAL A 246
SER A 249
 None
 0.76A 3nk7A-1ipaA:
24.2		 3nk7A-1ipaA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		8 / 12 GLY A 215
GLY A 220
ILE A 235
MET A 237
SER A 243
ASN A 245
VAL A 246
SER A 249
 None
 1.03A 3nk7A-1ipaA:
24.2		 3nk7A-1ipaA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		8 / 12 ASN A 129
GLY A 215
ILE A 235
MET A 237
SER A 243
LEU A 244
VAL A 246
SER A 249
 None
 0.71A 3nk7B-1ipaA:
21.0		 3nk7B-1ipaA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		7 / 12 ASN A 129
LEU A 253
ILE A 235
MET A 237
LEU A 244
VAL A 246
SER A 249
 None
 1.43A 3nk7B-1ipaA:
21.0		 3nk7B-1ipaA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		8 / 12 GLY A 215
GLY A 220
ILE A 235
MET A 237
SER A 243
LEU A 244
VAL A 246
SER A 249
 None
 0.89A 3nk7B-1ipaA:
21.0		 3nk7B-1ipaA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 TYR A  65
GLY A  56
LEU A  96
GLY A  95
ASN A  58
 None
 1.11A 3vywC-1ipaA:
undetectable		 3vywC-1ipaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ARG A  20
VAL A 147
GLY A 149
LEU A 130
SER A 155
 None
 1.36A 4or0A-1ipaA:
undetectable		 4or0A-1ipaA:
17.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 9 GLY A 215
ILE A 235
MET A 237
SER A 243
VAL A 246
 None
 0.73A 4x3mA-1ipaA:
25.3		 4x3mA-1ipaA:
53.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 9 GLY A 215
ILE A 235
MET A 237
SER A 243
LEU A 244
VAL A 246
 None
 0.74A 4x3mB-1ipaA:
30.4		 4x3mB-1ipaA:
53.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		7 / 12 THR A 193
GLY A 215
GLY A 220
ILE A 235
ASP A 242
SER A 243
LEU A 244
 None
 1.20A 5l0zA-1ipaA:
23.6		 5l0zA-1ipaA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA606_1
(SERUM ALBUMIN)		 1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ARG A  20
VAL A 147
GLY A 149
LEU A 130
SER A 155
 None
 1.37A 6ci6A-1ipaA:
undetectable		 6ci6A-1ipaA:
14.96