SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iqo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WEK_B_DIFB1376_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	1iqo	HYPOTHETICAL PROTEIN MTH1880 (Methanothermobac ter)	4 / 7	TYR A 59 GLY A 73 ALA A 72 LEU A 54	None	0.79A	2wekB-1iqoA: undetectable	2wekB-1iqoA: 13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BUP_B_SAMB500_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1)	1iqo	HYPOTHETICAL PROTEIN MTH1880 (Methanothermobac ter)	3 / 3	HIS A 87 GLU A 39 ASN A 60	None	1.00A	4bupB-1iqoA: undetectable	4bupB-1iqoA: 20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WBV_A_SAMA402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B)	1iqo	HYPOTHETICAL PROTEIN MTH1880 (Methanothermobac ter)	3 / 3	HIS A 87 GLU A 39 ASN A 60	None	0.97A	5wbvA-1iqoA: undetectable	5wbvA-1iqoA: 20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WBV_B_SAMB402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B)	1iqo	HYPOTHETICAL PROTEIN MTH1880 (Methanothermobac ter)	3 / 3	HIS A 87 GLU A 39 ASN A 60	None	0.98A	5wbvB-1iqoA: undetectable	5wbvB-1iqoA: 20.32

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2WEK_B_DIFB1376_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","1iqo","HYPOTHETICAL PROTEIN MTH1880","Methanothermobacter",4,"TYR A  59;GLY A  73;ALA A  72;LEU A  54","None","0.79A","2wekB-1iqoA:undetectable","2wekB-1iqoA:13.10"],["4BUP_B_SAMB500_1","HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1","1iqo","HYPOTHETICAL PROTEIN MTH1880","Methanothermobacter",3,"HIS A  87;GLU A  39;ASN A  60","None","1.00A","4bupB-1iqoA:undetectable","4bupB-1iqoA:20.32"],["5WBV_A_SAMA402_1","HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B","1iqo","HYPOTHETICAL PROTEIN MTH1880","Methanothermobacter",3,"HIS A  87;GLU A  39;ASN A  60","None","0.97A","5wbvA-1iqoA:undetectable","5wbvA-1iqoA:20.32"],["5WBV_B_SAMB402_1","HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B","1iqo","HYPOTHETICAL PROTEIN MTH1880","Methanothermobacter",3,"HIS A  87;GLU A  39;ASN A  60","None","0.98A","5wbvB-1iqoA:undetectable","5wbvB-1iqoA:20.32"]]