SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iqp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1iqp RFCS
(Pyrococcus
furiosus) 		4 / 5 PHE A 228
ILE A 239
PRO A 236
GLU A 279
 None
 1.49A 1oniG-1iqpA:
0.0
1oniH-1iqpA:
0.0		 1oniG-1iqpA:
17.99
1oniH-1iqpA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1iqp RFCS
(Pyrococcus
furiosus) 		4 / 7 ALA A 109
PHE A 100
ARG A  76
ASN A  74
 None
 1.28A 1t9wA-1iqpA:
2.6		 1t9wA-1iqpA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 1iqp RFCS
(Pyrococcus
furiosus) 		3 / 3 ARG A 165
GLY A  53
PRO A  54
 None
 0.58A 2hreD-1iqpA:
0.0		 2hreD-1iqpA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_A_AZZA1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1iqp RFCS
(Pyrococcus
furiosus) 		5 / 10 GLU A 237
GLN A 275
ARG A 235
ALA A 234
PHE A 228
 None
 1.26A 2jj8A-1iqpA:
2.1		 2jj8A-1iqpA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1iqp RFCS
(Pyrococcus
furiosus) 		5 / 12 GLU A 237
GLN A 275
ARG A 235
ALA A 234
PHE A 228
 None
 1.29A 2jj8B-1iqpA:
2.1		 2jj8B-1iqpA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1iqp RFCS
(Pyrococcus
furiosus) 		5 / 12 GLU A 237
GLN A 275
ARG A 235
ALA A 234
PHE A 228
 None
 1.28A 2jj8C-1iqpA:
2.1		 2jj8C-1iqpA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_D_AZZD1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1iqp RFCS
(Pyrococcus
furiosus) 		5 / 10 GLU A 237
GLN A 275
ARG A 235
ALA A 234
PHE A 228
 None
 1.27A 2jj8D-1iqpA:
2.0		 2jj8D-1iqpA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1iqp RFCS
(Pyrococcus
furiosus) 		5 / 8 ALA A 121
LEU A 122
LEU A 130
ILE A 153
ILE A 114
 None
 1.38A 2uxpA-1iqpA:
2.3		 2uxpA-1iqpA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 1iqp RFCS
(Pyrococcus
furiosus) 		5 / 12 GLU A 237
GLN A 275
ARG A 235
ALA A 234
PHE A 228
 None
 1.25A 2vppA-1iqpA:
1.9		 2vppA-1iqpA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 1iqp RFCS
(Pyrococcus
furiosus) 		5 / 12 GLU A 237
GLN A 275
ARG A 235
ALA A 234
PHE A 228
 None
 1.25A 2vppB-1iqpA:
2.0		 2vppB-1iqpA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1iqp RFCS
(Pyrococcus
furiosus) 		4 / 8 ALA A 175
GLU A 191
LEU A 194
LEU A 198
 None
 0.81A 4jjkA-1iqpA:
2.4		 4jjkA-1iqpA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1iqp RFCS
(Pyrococcus
furiosus) 		4 / 8 LEU A  82
LEU A 116
LEU A 145
VAL A 141
 None
 0.76A 4klaA-1iqpA:
undetectable		 4klaA-1iqpA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1iqp RFCS
(Pyrococcus
furiosus) 		5 / 11 ILE A 197
ARG A 179
LEU A 178
ALA A 175
VAL A 230
 None
 1.10A 4nqaA-1iqpA:
undetectable		 4nqaA-1iqpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1iqp RFCS
(Pyrococcus
furiosus) 		3 / 3 ALA A 162
GLN A  30
GLY A  29
 None
 0.52A 4odoC-1iqpA:
undetectable		 4odoC-1iqpA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1iqp RFCS
(Pyrococcus
furiosus) 		4 / 7 TYR A  40
ALA A  62
LEU A  49
PHE A  51
 None
 0.76A 4uymA-1iqpA:
0.0		 4uymA-1iqpA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1iqp RFCS
(Pyrococcus
furiosus) 		3 / 3 LEU A 317
ALA A 316
LEU A 273
 None
 0.48A 5uunB-1iqpA:
undetectable		 5uunB-1iqpA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1iqp RFCS
(Pyrococcus
furiosus) 		5 / 7 LEU A 314
ILE A 324
GLY A 325
LEU A 247
ILE A 239
 None
 1.17A 5vkqA-1iqpA:
2.2
5vkqB-1iqpA:
2.2		 5vkqA-1iqpA:
11.72
5vkqB-1iqpA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1iqp RFCS
(Pyrococcus
furiosus) 		5 / 8 LEU A 314
ILE A 324
GLY A 325
LEU A 247
ILE A 239
 None
 1.17A 5vkqB-1iqpA:
2.2
5vkqC-1iqpA:
2.2		 5vkqB-1iqpA:
11.72
5vkqC-1iqpA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 1iqp RFCS
(Pyrococcus
furiosus) 		4 / 7 GLN A 195
GLY A 193
ILE A 200
GLN A 265
 None
 1.11A 5vlmC-1iqpA:
3.0		 5vlmC-1iqpA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1iqp RFCS
(Pyrococcus
furiosus) 		4 / 6 PHE A 164
LEU A  49
ALA A 162
THR A  43
 None
 0.76A 6f88A-1iqpA:
0.0		 6f88A-1iqpA:
13.62