SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iqr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		4 / 8 ALA A 226
GLU A 229
LEU A 186
LEU A 183
 None
 0.90A 1ereE-1iqrA:
undetectable		 1ereE-1iqrA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		4 / 8 ALA A 226
GLU A 229
LEU A 186
LEU A 183
 None
 0.89A 1ereF-1iqrA:
undetectable		 1ereF-1iqrA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		6 / 12 ALA A 227
ALA A 226
LEU A 225
LEU A 124
ALA A 146
LEU A 212
 None
 1.26A 1fm9A-1iqrA:
undetectable		 1fm9A-1iqrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		4 / 8 TYR A  61
LEU A   4
LEU A 156
GLU A  22
 None
 0.97A 1i7zA-1iqrA:
undetectable		 1i7zA-1iqrA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		6 / 12 ALA A 227
ALA A 226
LEU A 225
LEU A 124
ALA A 146
LEU A 212
 None
 1.24A 1k74A-1iqrA:
undetectable		 1k74A-1iqrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		3 / 3 ARG A   9
GLY A 101
ASP A 105
 PO4  A 422 (-3.9A)
PO4  A 422 ( 4.7A)
None
 0.44A 1kf6A-1iqrA:
undetectable
1kf6B-1iqrA:
0.0		 1kf6A-1iqrA:
21.51
1kf6B-1iqrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		3 / 3 ARG A 313
GLY A 342
ASP A 341
 FAD  A 421 (-3.9A)
FAD  A 421 (-3.5A)
FAD  A 421 (-3.6A)
 0.57A 1kf6A-1iqrA:
undetectable
1kf6B-1iqrA:
0.0		 1kf6A-1iqrA:
21.51
1kf6B-1iqrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		5 / 12 ALA A 388
VAL A 295
ALA A 316
PHE A 319
LEU A 324
 None
 1.04A 1uduB-1iqrA:
undetectable		 1uduB-1iqrA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		3 / 3 GLU A 164
GLU A  72
LEU A  32
 None
 0.75A 1v8bB-1iqrA:
undetectable		 1v8bB-1iqrA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		5 / 12 LEU A 118
ASP A  11
HIS A   8
ALA A  25
VAL A   6
 None
 1.06A 2g70B-1iqrA:
2.3		 2g70B-1iqrA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA802_0
(FERROCHELATASE)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		4 / 6 ARG A 412
ARG A 409
PRO A 396
VAL A 401
 None
 0.97A 2qd4A-1iqrA:
1.7		 2qd4A-1iqrA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		3 / 3 SER A 251
TYR A 252
HIS A 253
 FAD  A 421 ( 4.1A)
None
None
 0.72A 2r2vD-1iqrA:
0.0		 2r2vD-1iqrA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		5 / 12 ALA A 226
GLU A 229
LEU A 212
LEU A 186
LEU A 183
 None
 1.15A 3hm1A-1iqrA:
undetectable		 3hm1A-1iqrA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		3 / 3 ASP A  11
ARG A  13
ARG A 104
 None
None
PO4  A 422 (-2.6A)
 0.90A 3k37A-1iqrA:
undetectable		 3k37A-1iqrA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		3 / 3 LYS A 240
ARG A 201
ASP A 360
 None
 1.24A 3o7wA-1iqrA:
1.2		 3o7wA-1iqrA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		3 / 3 TYR A 100
LEU A 339
ARG A 344
 None
FAD  A 421 (-4.6A)
None
 0.76A 3sufB-1iqrA:
undetectable		 3sufB-1iqrA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		3 / 3 LEU A 302
HIS A 303
MET A 299
 None
 0.62A 3thrD-1iqrA:
undetectable		 3thrD-1iqrA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_SALA1505_1
(FERROCHELATASE,
MITOCHONDRIAL)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		5 / 9 PRO A 170
LEU A 172
PRO A 175
TRP A  49
LEU A 340
 None
 1.30A 3w1wA-1iqrA:
1.9
3w1wB-1iqrA:
2.1		 3w1wA-1iqrA:
20.53
3w1wB-1iqrA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		4 / 8 ARG A 412
ARG A 409
PRO A 396
VAL A 401
 None
 0.91A 4f4dB-1iqrA:
1.6		 4f4dB-1iqrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		4 / 8 PRO A 122
ALA A 227
SER A 222
ASP A  16
 None
 0.90A 4k0bB-1iqrA:
undetectable		 4k0bB-1iqrA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		4 / 8 PRO A 122
ALA A 227
SER A 222
ASP A  16
 None
 0.88A 4l7iB-1iqrA:
undetectable		 4l7iB-1iqrA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		3 / 3 GLU A 244
ARG A 201
GLN A 349
 FAD  A 421 (-4.4A)
None
FAD  A 421 (-3.7A)
 0.53A 4rtbA-1iqrA:
undetectable		 4rtbA-1iqrA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		5 / 12 ALA A 226
LEU A 212
LEU A 186
LEU A 183
LEU A 245
 None
None
None
None
FAD  A 421 ( 4.6A)
 1.06A 4zn7A-1iqrA:
0.0		 4zn7A-1iqrA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		5 / 12 GLU A 229
LEU A 212
LEU A 186
LEU A 183
LEU A 245
 None
None
None
None
FAD  A 421 ( 4.6A)
 1.21A 4zn7A-1iqrA:
0.0		 4zn7A-1iqrA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		4 / 6 TYR A 256
ARG A 102
GLY A 101
SER A  96
 None
None
PO4  A 422 ( 4.7A)
PO4  A 422 (-2.6A)
 1.22A 5bphD-1iqrA:
2.3		 5bphD-1iqrA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		4 / 6 ARG A 311
HIS A 377
LEU A 372
PRO A 370
 None
 1.49A 5syjB-1iqrA:
undetectable		 5syjB-1iqrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		6 / 12 ALA A 227
ALA A 226
LEU A 225
LEU A 124
ALA A 146
LEU A 212
 None
 1.18A 5z12B-1iqrA:
undetectable		 5z12B-1iqrA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1iqr PHOTOLYASE
(Thermus
thermophilus) 		4 / 8 LEU A 172
LEU A 174
LEU A 339
GLY A 342
 None
None
FAD  A 421 (-4.6A)
FAD  A 421 (-3.5A)
 0.90A 6ce2A-1iqrA:
undetectable		 6ce2A-1iqrA:
10.87