SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ir6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 ALA A 281
GLY A  88
GLY A  85
ILE A 107
ILE A  91
 None
 1.03A 1x1aA-1ir6A:
undetectable		 1x1aA-1ir6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		4 / 5 LEU A 131
GLY A  95
ALA A  68
ILE A  75
 None
 0.82A 2aohB-1ir6A:
undetectable		 2aohB-1ir6A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 11 ARG A 271
ILE A 268
LEU A 251
ALA A 296
ASP A 292
 None
 1.07A 2fxdA-1ir6A:
undetectable		 2fxdA-1ir6A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		3 / 3 PHE A 400
PHE A 410
PHE A 407
 None
 0.86A 2od9A-1ir6A:
6.6		 2od9A-1ir6A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		3 / 3 ILE A  75
ILE A 156
LEU A 289
 None
 0.53A 2prgA-1ir6A:
undetectable		 2prgA-1ir6A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 ILE A 272
ALA A 269
GLY A 217
ASP A 212
GLY A  85
 None
 0.85A 2qe6A-1ir6A:
2.3		 2qe6A-1ir6A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 ILE A 272
ALA A 269
GLY A 217
ASP A 212
GLY A  85
 None
 0.86A 2qe6B-1ir6A:
3.0		 2qe6B-1ir6A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		3 / 3 PHE A 400
PHE A 410
PHE A 407
 None
 0.86A 2qqgA-1ir6A:
6.6		 2qqgA-1ir6A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 GLU A 209
HIS A 199
ALA A  61
LEU A 133
ILE A  91
 None
 1.34A 2xkwB-1ir6A:
0.0		 2xkwB-1ir6A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		4 / 5 HIS A 160
HIS A 161
ASP A 221
ASP A  82
 MN  A1434 (-3.4A)
MN  A1434 (-4.3A)
MN  A1434 (-2.7A)
MN  A1434 ( 4.4A)
 1.26A 3c0zA-1ir6A:
undetectable		 3c0zA-1ir6A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 GLY A  85
GLY A 138
GLY A 116
GLY A  79
ILE A 139
 None
 1.04A 3eluA-1ir6A:
2.1		 3eluA-1ir6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		4 / 6 GLY A  57
THR A 158
GLU A  60
GLU A  66
 None
 0.72A 3fpjA-1ir6A:
3.1		 3fpjA-1ir6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		4 / 7 GLY A  57
THR A 158
GLU A  60
GLU A  66
 None
 0.72A 3fpjB-1ir6A:
3.6		 3fpjB-1ir6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 GLY A  85
GLY A 138
GLY A 116
GLY A  79
ILE A 139
 None
 1.04A 3gczA-1ir6A:
2.3		 3gczA-1ir6A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 11 LEU A 288
ILE A 272
ALA A 215
THR A 218
ALA A  83
 None
 1.00A 3mdtB-1ir6A:
0.0		 3mdtB-1ir6A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 11 LEU A  64
LEU A 171
GLY A  57
GLU A  60
LEU A 194
 None
 1.41A 3ndvC-1ir6A:
0.0
3ndvD-1ir6A:
0.0		 3ndvC-1ir6A:
25.00
3ndvD-1ir6A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 11 LEU A  58
LEU A  65
VAL A 190
GLY A 189
ALA A 191
 None
 1.27A 3pghB-1ir6A:
0.0		 3pghB-1ir6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 ALA A 254
LEU A 250
GLY A 301
HIS A 304
ALA A 275
 None
 1.20A 3tm4A-1ir6A:
2.9		 3tm4A-1ir6A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 ALA A 254
LEU A 250
GLY A 301
HIS A 304
ALA A 275
 None
 1.25A 3tm4B-1ir6A:
2.6		 3tm4B-1ir6A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 8 LEU A 285
LEU A 288
LEU A 213
ILE A 107
VAL A 135
 None
 1.39A 4klaA-1ir6A:
undetectable		 4klaA-1ir6A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 11 HIS A  78
PRO A 108
HIS A 160
HIS A 161
ASP A  82
 None
None
MN  A1434 (-3.4A)
MN  A1434 (-4.3A)
MN  A1434 ( 4.4A)
 1.33A 4lxzB-1ir6A:
undetectable		 4lxzB-1ir6A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 11 HIS A  78
PRO A 108
HIS A 161
ASP A  82
GLY A  85
 None
None
MN  A1434 (-4.3A)
MN  A1434 ( 4.4A)
None
 1.27A 4lxzB-1ir6A:
undetectable		 4lxzB-1ir6A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 PRO A 108
HIS A 160
HIS A 161
ASP A  82
GLY A  85
 None
MN  A1434 (-3.4A)
MN  A1434 (-4.3A)
MN  A1434 ( 4.4A)
None
 1.13A 4lxzC-1ir6A:
undetectable		 4lxzC-1ir6A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 VAL A 369
ALA A 397
PHE A 410
PHE A 400
GLY A 393
 None
 1.23A 4mm6A-1ir6A:
undetectable		 4mm6A-1ir6A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 8 ALA A 220
ALA A 265
ILE A 219
ALA A 252
LEU A 237
 None
 1.41A 4v1fA-1ir6A:
undetectable
4v1fB-1ir6A:
undetectable		 4v1fA-1ir6A:
13.65
4v1fB-1ir6A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 GLY A 170
GLU A 144
LEU A 194
LEU A 198
ALA A  63
 None
 1.20A 4wcxC-1ir6A:
undetectable		 4wcxC-1ir6A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 GLY A  85
LEU A 285
VAL A 135
VAL A  77
VAL A  93
 None
 1.11A 5dpdA-1ir6A:
undetectable		 5dpdA-1ir6A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 GLY A  85
LEU A 285
VAL A 135
VAL A  77
VAL A  93
 None
 1.09A 5dpdB-1ir6A:
undetectable		 5dpdB-1ir6A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 HIS A  78
PRO A 108
HIS A 160
HIS A 161
ASP A  82
 None
None
MN  A1434 (-3.4A)
MN  A1434 (-4.3A)
MN  A1434 ( 4.4A)
 1.42A 5eenB-1ir6A:
undetectable		 5eenB-1ir6A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 10 PRO A 185
LEU A  55
ILE A  91
LEU A  92
LEU A  50
 None
 1.13A 5ienB-1ir6A:
0.0		 5ienB-1ir6A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 LEU A 225
ASP A  84
GLY A 217
LEU A 237
ALA A 261
 None
MN  A1434 (-3.4A)
None
None
None
 1.08A 5kc4E-1ir6A:
0.9		 5kc4E-1ir6A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		4 / 8 ASP A 136
HIS A 160
HIS A 161
ARG A 277
 MN  A1434 (-2.4A)
MN  A1434 (-3.4A)
MN  A1434 (-4.3A)
None
 0.84A 5nekB-1ir6A:
undetectable		 5nekB-1ir6A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		3 / 3 ASN A 151
VAL A 117
HIS A 125
 None
 0.72A 6a5yD-1ir6A:
undetectable		 6a5yD-1ir6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 1ir6 EXONUCLEASE RECJ
(Thermus
thermophilus) 		5 / 12 ILE A 240
VAL A 233
LEU A 248
THR A  87
LEU A 288
 None
 1.25A 6b54A-1ir6A:
undetectable		 6b54A-1ir6A:
20.55