SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1irf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 1irf INTERFERON
REGULATORY FACTOR-2
(Mus
musculus) 		5 / 11 ILE A  36
PRO A  37
ILE A  16
PHE A  81
TRP A  58
 None
 1.28A 2aqjA-1irfA:
0.0		 2aqjA-1irfA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKC_A_TRPA1520_0
(FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA)		 1irf INTERFERON
REGULATORY FACTOR-2
(Mus
musculus) 		5 / 10 ILE A  36
PRO A  37
ILE A  16
PHE A  81
TRP A  58
 None
 1.25A 2jkcA-1irfA:
undetectable		 2jkcA-1irfA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 1irf INTERFERON
REGULATORY FACTOR-2
(Mus
musculus) 		4 / 5 ILE A  16
LEU A  12
ASP A  51
PHE A  81
 None
 1.06A 2opxA-1irfA:
undetectable		 2opxA-1irfA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 1irf INTERFERON
REGULATORY FACTOR-2
(Mus
musculus) 		4 / 7 ASN A  86
ARG A  82
GLU A  93
ARG A 107
 None
 1.30A 6b8kA-1irfA:
undetectable		 6b8kA-1irfA:
20.83