SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1irx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A  35
GLY A  37
GLU A  41
GLY A 237
ASP A 239
 None
 0.63A 1pg2A-1irxA:
14.2		 1pg2A-1irxA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A  35
GLY A  37
GLU A  41
GLY A 237
VAL A 271
 None
 0.76A 1pg2A-1irxA:
14.2		 1pg2A-1irxA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 PHE A  39
ILE A 273
GLY A  37
ILE A 315
VAL A 287
 None
 1.16A 1sg9A-1irxA:
undetectable		 1sg9A-1irxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 PHE A  39
ILE A 273
GLY A  37
ILE A 315
VAL A 287
 None
 1.13A 1vq1A-1irxA:
undetectable		 1vq1A-1irxA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 GLU A 298
ARG A 413
ILE A 305
ASP A 328
GLU A 331
 None
 1.23A 2qeoB-1irxA:
0.0		 2qeoB-1irxA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 PHE A 431
VAL A 421
SER A 509
SER A 505
ARG A 418
 None
 1.24A 2qm9A-1irxA:
undetectable		 2qm9A-1irxA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 PHE A 431
VAL A 421
SER A 509
SER A 505
ARG A 418
 None
 1.24A 2qm9B-1irxA:
undetectable		 2qm9B-1irxA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A  35
GLY A  37
GLU A  41
GLY A 237
ASP A 239
 None
 0.81A 2x1lA-1irxA:
14.5		 2x1lA-1irxA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A  35
GLY A  37
GLU A  41
GLY A 237
ASP A 239
 None
 0.75A 2x1lB-1irxA:
14.5		 2x1lB-1irxA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A  35
GLY A  37
GLU A  41
GLY A 237
ASP A 239
 None
 0.83A 2x1lC-1irxA:
14.8		 2x1lC-1irxA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 PRO A 299
GLU A 295
TYR A 294
 None
 0.70A 2zmbA-1irxA:
1.6		 2zmbA-1irxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ARG A 409
PRO A 359
GLY A 300
PRO A 299
 None
 1.06A 3hcrA-1irxA:
undetectable		 3hcrA-1irxA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 414
SER A 509
ILE A 398
VAL A 465
PHE A 468
 None
 1.08A 3w67B-1irxA:
undetectable		 3w67B-1irxA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 TYR A 424
ASP A 318
GLU A 329
LEU A 293
 None
 1.40A 4ax8A-1irxA:
2.6		 4ax8A-1irxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 PHE A 107
HIS A 106
GLU A 105
ILE A  90
 None
ZN  A 600 (-3.3A)
None
None
 1.14A 4cx7A-1irxA:
0.0
4cx7B-1irxA:
0.0		 4cx7A-1irxA:
21.42
4cx7B-1irxA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A  72
TYR A  33
ASN A  38
 None
 0.82A 4ffwB-1irxA:
0.2		 4ffwB-1irxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 315
ILE A  47
LEU A 118
VAL A 115
LEU A 290
 None
 1.03A 4km2A-1irxA:
undetectable		 4km2A-1irxA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ASP A  66
ASP A 221
ALA A 173
ASP A  69
 None
 1.19A 4mdaA-1irxA:
0.3		 4mdaA-1irxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ASP A  66
ASP A 221
ALA A 173
ASP A  69
 None
 1.21A 4mdbA-1irxA:
0.4		 4mdbA-1irxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ASN A 325
GLU A 331
TYR A 327
TYR A 337
 None
 1.16A 4mj8A-1irxA:
0.2
4mj8C-1irxA:
0.2		 4mj8A-1irxA:
16.63
4mj8C-1irxA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 GLU A  92
SER A 211
TRP A 193
ASP A 190
 None
 1.21A 4uacA-1irxA:
1.4		 4uacA-1irxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 ARG A 492
LEU A 493
LEU A 521
GLU A 448
ALA A 449
 None
 1.16A 4wg0J-1irxA:
undetectable
4wg0K-1irxA:
undetectable
4wg0L-1irxA:
undetectable		 4wg0J-1irxA:
4.17
4wg0K-1irxA:
4.17
4wg0L-1irxA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 PHE A 229
GLU A  25
VAL A  24
GLU A 261
GLY A 259
 None
 1.46A 4ydqB-1irxA:
undetectable		 4ydqB-1irxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 VAL A 207
TYR A 176
VAL A 175
SER A 211
 None
 0.94A 5jwaH-1irxA:
2.2		 5jwaH-1irxA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 301
GLY A 272
ILE A 273
VAL A 302
ILE A 305
 None
 1.14A 5kr2D-1irxA:
undetectable		 5kr2D-1irxA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 PRO A 311
ILE A   8
THR A  44
ILE A  47
 None
 0.81A 5mzrE-1irxA:
0.0		 5mzrE-1irxA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 412
GLY A 300
PRO A 359
VAL A 115
PHE A  39
 None
 1.22A 5x6yA-1irxA:
undetectable		 5x6yA-1irxA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 4 GLY A 322
ARG A 372
ASN A 325
LEU A 321
 None
 1.36A 6b58A-1irxA:
0.1		 6b58A-1irxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1irx LYSYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 TYR A 337
ARG A 351
THR A 353
LEU A 356
 None
 1.19A 6nknW-1irxA:
0.0		 6nknW-1irxA:
9.61