SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1is1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1is1 RIBOSOME RECYCLING
FACTOR
(Vibrio
parahaemolyticus) 		4 / 5 LEU A  65
PRO A  91
VAL A 100
ILE A  67
 None
 0.94A 2aoiB-1is1A:
undetectable		 2aoiB-1is1A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1is1 RIBOSOME RECYCLING
FACTOR
(Vibrio
parahaemolyticus) 		5 / 11 LEU A  37
VAL A  78
LEU A  65
VAL A  69
ILE A  98
 None
 1.19A 2uxoB-1is1A:
1.1		 2uxoB-1is1A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1is1 RIBOSOME RECYCLING
FACTOR
(Vibrio
parahaemolyticus) 		5 / 12 GLY A  88
SER A  85
ALA A  81
ILE A  40
LEU A  37
 None
 1.27A 3adsB-1is1A:
0.0		 3adsB-1is1A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1is1 RIBOSOME RECYCLING
FACTOR
(Vibrio
parahaemolyticus) 		4 / 4 VAL A  27
ARG A 118
ILE A 171
THR A  29
 None
 1.37A 3cl9A-1is1A:
undetectable		 3cl9A-1is1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 1is1 RIBOSOME RECYCLING
FACTOR
(Vibrio
parahaemolyticus) 		4 / 4 LEU A  36
LEU A 102
GLY A  30
GLU A 181
 None
 1.04A 5hhjA-1is1A:
0.0		 5hhjA-1is1A:
21.61