SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1is7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1is7 GTP CYCLOHYDROLASE I
(Rattus
norvegicus) 		4 / 8 VAL A 163
VAL A 121
VAL A 123
LEU A 159
 None
 0.81A 1igxA-1is7A:
undetectable		 1igxA-1is7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1is7 GTP CYCLOHYDROLASE I
(Rattus
norvegicus) 		5 / 8 ILE A 162
LEU A 159
ILE A 145
VAL A 143
ILE A 180
 None
 1.34A 1linA-1is7A:
undetectable		 1linA-1is7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 1is7 GTP CYCLOHYDROLASE I
(Rattus
norvegicus) 		5 / 9 LEU A 154
ALA A 183
VAL A 193
LEU A 222
ILE A 184
 None
 1.43A 3wsjA-1is7A:
0.0		 3wsjA-1is7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 1is7 GTP CYCLOHYDROLASE I
(Rattus
norvegicus) 		5 / 12 GLY A 223
GLY A 146
GLY A 192
HIS A 144
ILE A 180
 None
 0.91A 4ctjC-1is7A:
undetectable		 4ctjC-1is7A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1is7 GTP CYCLOHYDROLASE I
(Rattus
norvegicus) 		5 / 12 THR A 216
ILE A 180
VAL A 143
HIS A 144
ILE A 145
 None
 1.12A 4rvgA-1is7A:
undetectable		 4rvgA-1is7A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1is7 GTP CYCLOHYDROLASE I
(Rattus
norvegicus) 		5 / 10 ALA A 181
ILE A 184
TYR A 147
GLY A 194
VAL A 163
 None
 1.11A 5i6xA-1is7A:
1.0		 5i6xA-1is7A:
16.79