SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1isc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1isc IRON(III) SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		4 / 6 GLY A 172
PRO A 171
ILE A 115
TYR A 162
 None
 0.86A 2jkjA-1iscA:
0.0		 2jkjA-1iscA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1isc IRON(III) SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		4 / 6 GLY A 172
PRO A 171
ILE A 115
TYR A 162
 None
 0.86A 2jkjB-1iscA:
0.0		 2jkjB-1iscA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1isc IRON(III) SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		4 / 6 GLY A 172
PRO A 171
ILE A 115
TYR A 162
 None
 0.86A 2jkjC-1iscA:
undetectable		 2jkjC-1iscA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 1isc IRON(III) SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		4 / 7 TYR A  27
HIS A  73
HIS A  30
TYR A  34
 None
AZI  A 195 (-2.7A)
AZI  A 195 (-4.6A)
AZI  A 195 (-4.2A)
 1.30A 2ombC-1iscA:
undetectable
2ombD-1iscA:
undetectable		 2ombC-1iscA:
24.03
2ombD-1iscA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 1isc IRON(III) SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		4 / 8 ILE A  18
LEU A 180
PHE A 177
TYR A 173
 None
 0.75A 2vdbA-1iscA:
undetectable		 2vdbA-1iscA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 1isc IRON(III) SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		4 / 6 PHE A 103
PHE A 106
ALA A 108
THR A 111
 None
 1.07A 3t3sB-1iscA:
0.0		 3t3sB-1iscA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 1isc IRON(III) SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		4 / 6 TYR A 173
HIS A  26
HIS A  73
TYR A  76
 None
FE  A 193 (-3.3A)
AZI  A 195 (-2.7A)
None
 1.49A 4df2A-1iscA:
undetectable		 4df2A-1iscA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1isc IRON(III) SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		4 / 5 ILE A  42
GLY A  62
ILE A  55
LEU A  41
 None
 0.91A 5dzkd-1iscA:
undetectable
5dzkk-1iscA:
undetectable
5dzky-1iscA:
undetectable		 5dzkd-1iscA:
22.46
5dzkk-1iscA:
19.63
5dzky-1iscA:
1.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1isc IRON(III) SUPEROXIDE
DISMUTASE
(Escherichia
coli) 		5 / 11 ILE A  18
ALA A 161
ASP A 156
LEU A   7
ILE A  23
 None
None
FE  A 193 ( 2.5A)
None
None
 1.06A 5z6mA-1iscA:
undetectable		 5z6mA-1iscA:
21.26