SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ism'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		5 / 10 GLY A   6
SER A   8
LEU A  11
TRP A 111
LEU A 109
 None
 1.27A 1a8uA-1ismA:
undetectable		 1a8uA-1ismA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		5 / 10 GLY A   6
SER A   8
LEU A  11
TRP A 111
LEU A 109
 None
 1.28A 1a8uB-1ismA:
undetectable		 1a8uB-1ismA:
22.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ISI_A_NCAA1002_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		4 / 4 TRP A  77
GLU A  78
PHE A 173
GLU A 178
 NCA  A 303 (-4.4A)
None
NCA  A 303 (-3.7A)
NCA  A 303 ( 4.4A)
 0.59A 1isiA-1ismA:
40.3		 1isiA-1ismA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ISI_B_NCAB1001_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		4 / 4 TRP A  77
GLU A  78
PHE A 173
GLU A 178
 NCA  A 303 (-4.4A)
None
NCA  A 303 (-3.7A)
NCA  A 303 ( 4.4A)
 0.47A 1isiB-1ismA:
40.2		 1isiB-1ismA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ISM_A_NCAA303_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		9 / 9 TRP A  77
HIS A  81
LEU A  97
SER A  98
ASP A 107
TRP A 140
SER A 144
PHE A 173
GLU A 178
 NCA  A 303 (-4.4A)
NCA  A 303 (-4.1A)
NCA  A 303 (-4.3A)
NCA  A 303 (-3.9A)
NCA  A 303 (-4.4A)
NCA  A 303 (-4.0A)
NCA  A 303 ( 3.7A)
NCA  A 303 (-3.7A)
NCA  A 303 ( 4.4A)
 0.00A 1ismA-1ismA:
43.0		 1ismA-1ismA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		7 / 7 TRP A  77
HIS A  81
LEU A  97
SER A  98
ASP A 107
TRP A 140
PHE A 173
 NCA  A 303 (-4.4A)
NCA  A 303 (-4.1A)
NCA  A 303 (-4.3A)
NCA  A 303 (-3.9A)
NCA  A 303 (-4.4A)
NCA  A 303 (-4.0A)
NCA  A 303 (-3.7A)
 0.12A 1ismB-1ismA:
40.7		 1ismB-1ismA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		3 / 3 TRP A 111
PHE A 139
TRP A 140
 None
None
NCA  A 303 (-4.0A)
 0.29A 1r15C-1ismA:
28.8		 1r15C-1ismA:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		3 / 3 TRP A 111
PHE A 139
TRP A 140
 None
None
NCA  A 303 (-4.0A)
 0.26A 1r15F-1ismA:
28.7		 1r15F-1ismA:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		3 / 3 TRP A 111
PHE A 139
TRP A 140
 None
None
NCA  A 303 (-4.0A)
 0.29A 1r15G-1ismA:
28.8		 1r15G-1ismA:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		3 / 3 TRP A 111
PHE A 139
TRP A 140
 None
None
NCA  A 303 (-4.0A)
 0.29A 1r15H-1ismA:
28.7		 1r15H-1ismA:
33.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		3 / 3 ASP A  99
ARG A 104
ASP A  89
 None
 0.92A 1vptA-1ismA:
undetectable		 1vptA-1ismA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		4 / 7 GLY A 200
GLY A 199
ASP A 230
VAL A 203
 None
 0.70A 2oa1B-1ismA:
undetectable		 2oa1B-1ismA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		5 / 12 ALA A  20
ARG A  23
ILE A  38
ASP A  34
PHE A  15
 None
 1.25A 2v95A-1ismA:
0.0		 2v95A-1ismA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		4 / 8 GLY A 166
THR A 165
GLU A 204
GLY A 161
 None
 0.77A 3aruA-1ismA:
2.0		 3aruA-1ismA:
18.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		5 / 7 TRP A  77
LEU A  97
ASP A 107
TRP A 140
SER A 144
 NCA  A 303 (-4.4A)
NCA  A 303 (-4.3A)
NCA  A 303 (-4.4A)
NCA  A 303 (-4.0A)
NCA  A 303 ( 3.7A)
 0.43A 3dzgA-1ismA:
14.9		 3dzgA-1ismA:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		5 / 7 TRP A  77
LEU A  97
ASP A 107
TRP A 140
SER A 144
 NCA  A 303 (-4.4A)
NCA  A 303 (-4.3A)
NCA  A 303 (-4.4A)
NCA  A 303 (-4.0A)
NCA  A 303 ( 3.7A)
 0.49A 3dzgB-1ismA:
28.0		 3dzgB-1ismA:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		4 / 6 LEU A  97
TRP A 140
SER A 144
PHE A 173
 NCA  A 303 (-4.3A)
NCA  A 303 (-4.0A)
NCA  A 303 ( 3.7A)
NCA  A 303 (-3.7A)
 0.50A 3i9jB-1ismA:
27.8		 3i9jB-1ismA:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens) 		4 / 6 TRP A  77
LEU A  97
TRP A 140
SER A 144
 NCA  A 303 (-4.4A)
NCA  A 303 (-4.3A)
NCA  A 303 (-4.0A)
NCA  A 303 ( 3.7A)
 0.29A 3ropA-1ismA:
14.6		 3ropA-1ismA:
34.53