SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ist'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ist CYCLOPHILIN A
(Saccharomyces
cerevisiae) 		4 / 6 ARG A  53
ILE A  55
GLY A 148
ALA A 149
 None
 0.96A 1wmqA-1istA:
0.0		 1wmqA-1istA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ist CYCLOPHILIN A
(Saccharomyces
cerevisiae) 		4 / 6 ARG A  53
ILE A  55
GLY A 148
ALA A 149
 None
 0.96A 1wmqB-1istA:
0.0		 1wmqB-1istA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ist CYCLOPHILIN A
(Saccharomyces
cerevisiae) 		4 / 6 ARG A  53
ILE A  55
GLY A 148
ALA A 149
 None
 0.94A 1wpuA-1istA:
0.0		 1wpuA-1istA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ist CYCLOPHILIN A
(Saccharomyces
cerevisiae) 		4 / 6 ARG A  53
ILE A  55
GLY A 148
ALA A 149
 None
 0.95A 1wpuB-1istA:
0.0		 1wpuB-1istA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ist CYCLOPHILIN A
(Saccharomyces
cerevisiae) 		4 / 6 ARG A  53
ILE A  55
GLY A 148
ALA A 149
 None
 0.92A 1wrqA-1istA:
0.0		 1wrqA-1istA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ist CYCLOPHILIN A
(Saccharomyces
cerevisiae) 		4 / 6 ARG A  53
ILE A  55
GLY A 148
ALA A 149
 None
 0.94A 1wrqB-1istA:
0.0		 1wrqB-1istA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 1ist CYCLOPHILIN A
(Saccharomyces
cerevisiae) 		3 / 3 TYR A  46
GLY A  48
PHE A  65
 None
 0.61A 2m2pB-1istA:
undetectable		 2m2pB-1istA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1ist CYCLOPHILIN A
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  20
PHE A  34
GLY A  62
GLY A  63
 None
 0.88A 2qr2A-1istA:
undetectable
2qr2B-1istA:
undetectable		 2qr2A-1istA:
22.07
2qr2B-1istA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1ist CYCLOPHILIN A
(Saccharomyces
cerevisiae) 		4 / 5 GLY A  62
GLY A  63
PHE A  20
PHE A  34
 None
 0.83A 2qr2A-1istA:
undetectable
2qr2B-1istA:
undetectable		 2qr2A-1istA:
22.07
2qr2B-1istA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ist CYCLOPHILIN A
(Saccharomyces
cerevisiae) 		4 / 8 PHE A  20
PHE A  34
GLY A  62
GLY A  63
 None
 0.78A 2qx4A-1istA:
undetectable
2qx4B-1istA:
undetectable		 2qx4A-1istA:
22.07
2qx4B-1istA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ist CYCLOPHILIN A
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  20
PHE A  34
GLY A  62
GLY A  63
 None
 0.78A 2qx6A-1istA:
undetectable
2qx6B-1istA:
undetectable		 2qx6A-1istA:
22.07
2qx6B-1istA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1ist CYCLOPHILIN A
(Saccharomyces
cerevisiae) 		4 / 5 TYR A  46
VAL A 156
SER A  49
GLY A  62
 None
 1.28A 3v4tA-1istA:
undetectable
3v4tD-1istA:
0.0		 3v4tA-1istA:
16.90
3v4tD-1istA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 1ist CYCLOPHILIN A
(Saccharomyces
cerevisiae) 		4 / 6 ALA A  31
ASN A  24
LEU A  22
ASP A  25
 None
 0.96A 4g24A-1istA:
undetectable		 4g24A-1istA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 1ist CYCLOPHILIN A
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  47
TYR A  46
GLY A  40
ASP A  64
THR A  66
 None
 1.22A 4mm4A-1istA:
undetectable		 4mm4A-1istA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1ist CYCLOPHILIN A
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 107
ILE A  76
ASN A 100
PHE A  34
LEU A  96
 None
 1.01A 5fa8A-1istA:
undetectable		 5fa8A-1istA:
24.29