SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ith'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1ith HEMOGLOBIN (CYANO
MET)
(Urechis
caupo) 		5 / 8 LEU A  79
ALA A 128
GLY A 112
VAL A  76
ILE A  10
 None
 1.16A 1d4yB-1ithA:
undetectable		 1d4yB-1ithA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1ith HEMOGLOBIN (CYANO
MET)
(Urechis
caupo) 		4 / 7 PHE A  44
PHE A  47
VAL A  68
HIS A  94
 HEM  A 143 ( 4.3A)
None
HEM  A 143 (-4.3A)
HEM  A 143 (-3.3A)
 0.95A 1lh6A-1ithA:
11.7		 1lh6A-1ithA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 1ith HEMOGLOBIN (CYANO
MET)
(Urechis
caupo) 		5 / 12 VAL A 111
LEU A  72
GLY A 134
ALA A 133
LEU A 108
 None
None
None
None
HEM  A 143 ( 4.9A)
 1.28A 3pghA-1ithA:
undetectable		 3pghA-1ithA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ith HEMOGLOBIN (CYANO
MET)
(Urechis
caupo) 		4 / 8 ILE A  10
LEU A  79
VAL A 135
GLY A 134
 None
 0.90A 3w1wA-1ithA:
undetectable		 3w1wA-1ithA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1ith HEMOGLOBIN (CYANO
MET)
(Urechis
caupo) 		3 / 3 ASP A  12
LEU A  16
PHE A  15
 None
 0.75A 4pthA-1ithA:
undetectable		 4pthA-1ithA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ith HEMOGLOBIN (CYANO
MET)
(Urechis
caupo) 		4 / 6 ILE A  99
ILE A  69
LEU A  72
PHE A 119
 HEM  A 143 (-3.9A)
None
None
None
 0.92A 5vkqB-1ithA:
2.2
5vkqC-1ithA:
2.2		 5vkqB-1ithA:
6.46
5vkqC-1ithA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ith HEMOGLOBIN (CYANO
MET)
(Urechis
caupo) 		4 / 6 ILE A  99
ILE A  69
LEU A  72
PHE A 119
 HEM  A 143 (-3.9A)
None
None
None
 0.90A 5vkqC-1ithA:
2.2
5vkqD-1ithA:
2.2		 5vkqC-1ithA:
6.46
5vkqD-1ithA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 1ith HEMOGLOBIN (CYANO
MET)
(Urechis
caupo) 		5 / 10 GLY A  80
GLY A  81
ASN A  82
ILE A   7
ALA A  78
 None
 1.09A 6e5zA-1ithA:
undetectable		 6e5zA-1ithA:
22.11