SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1itu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 8 TYR A  96
PHE A 100
MET A  92
THR A  48
 NAG  A 461 ( 4.3A)
None
None
None
 1.25A 1ea1A-1ituA:
undetectable		 1ea1A-1ituA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		5 / 10 LEU A 312
LEU A 313
ALA A 310
LEU A 326
LEU A 264
 None
 1.22A 1gwrA-1ituA:
0.0		 1gwrA-1ituA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 4 GLY A 358
LEU A 357
GLY A 359
ARG A 362
 None
 1.18A 1j7kA-1ituA:
1.0		 1j7kA-1ituA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 8 LEU A  35
LEU A  45
ILE A  52
MET A  95
 None
None
None
NAG  A 461 (-3.7A)
 0.87A 1n13A-1ituA:
0.0
1n13F-1ituA:
undetectable		 1n13A-1ituA:
10.03
1n13F-1ituA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 7 LEU A  35
LEU A  45
ILE A  52
MET A  95
 None
None
None
NAG  A 461 (-3.7A)
 0.88A 1n13I-1ituA:
0.0
1n13L-1ituA:
0.0		 1n13I-1ituA:
10.03
1n13L-1ituA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		5 / 10 GLY A 286
VAL A 249
LEU A 271
LEU A 308
TYR A 305
 None
 1.21A 1pbcA-1ituA:
undetectable		 1pbcA-1ituA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A 308
LEU A 271
GLY A 286
ASP A  18
ASP A 290
 None
 1.31A 2bm9B-1ituA:
undetectable		 2bm9B-1ituA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 7 ILE A  52
MET A  95
LEU A  35
LEU A  45
 None
NAG  A 461 (-3.7A)
None
None
 0.94A 2qqcB-1ituA:
0.0
2qqcC-1ituA:
0.0		 2qqcB-1ituA:
14.36
2qqcC-1ituA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 7 LEU A  35
LEU A  45
ILE A  52
MET A  95
 None
None
None
NAG  A 461 (-3.7A)
 0.94A 2qqcA-1ituA:
0.0
2qqcF-1ituA:
0.0		 2qqcA-1ituA:
10.03
2qqcF-1ituA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 7 LEU A  35
LEU A  45
ILE A  52
MET A  95
 None
None
None
NAG  A 461 (-3.7A)
 0.92A 2qqcG-1ituA:
0.0
2qqcJ-1ituA:
0.0		 2qqcG-1ituA:
10.03
2qqcJ-1ituA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 7 LEU A  35
LEU A  45
ILE A  52
MET A  95
 None
None
None
NAG  A 461 (-3.7A)
 0.98A 2qqcI-1ituA:
0.0
2qqcL-1ituA:
0.0		 2qqcI-1ituA:
10.03
2qqcL-1ituA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 7 LEU A  35
LEU A  45
ILE A  52
MET A  95
 None
None
None
NAG  A 461 (-3.7A)
 0.87A 2qqdA-1ituA:
0.0
2qqdE-1ituA:
0.0		 2qqdA-1ituA:
10.03
2qqdE-1ituA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 8 ILE A  52
MET A  95
LEU A  35
LEU A  45
 None
NAG  A 461 (-3.7A)
None
None
 0.86A 2qqdB-1ituA:
0.0
2qqdC-1ituA:
0.0		 2qqdB-1ituA:
14.36
2qqdC-1ituA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		5 / 12 ILE A 216
VAL A 199
VAL A 232
VAL A 236
VAL A 240
 None
 1.19A 3iw1A-1ituA:
0.0		 3iw1A-1ituA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		3 / 3 ASP A 235
ARG A 238
ARG A 229
 None
 0.97A 3k37A-1ituA:
undetectable		 3k37A-1ituA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		3 / 3 GLU A 311
LEU A 308
ASP A 307
 None
 0.48A 3ko0A-1ituA:
undetectable		 3ko0A-1ituA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		5 / 12 ILE A  17
VAL A  16
GLY A 284
ALA A 327
LEU A 326
 None
 1.04A 3mb5A-1ituA:
undetectable		 3mb5A-1ituA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		5 / 12 VAL A 249
VAL A 247
LEU A 246
GLY A 279
ALA A 278
 None
 0.93A 3n8yB-1ituA:
0.0		 3n8yB-1ituA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		5 / 12 VAL A 247
LEU A 246
GLY A 279
ALA A 278
LEU A 237
 None
 1.29A 3pghA-1ituA:
undetectable		 3pghA-1ituA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		5 / 12 ARG A 230
HIS A 152
ALA A 159
SER A  66
ASP A  22
 CIL  A 451 (-4.0A)
CIL  A 451 (-4.0A)
None
ZN  A 401 ( 3.7A)
ZN  A 401 ( 2.2A)
 1.36A 4aqlA-1ituA:
5.9		 4aqlA-1ituA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A  42
PHE A 100
PRO A  24
VAL A  88
SER A 120
 None
 1.38A 4b3aA-1ituA:
undetectable		 4b3aA-1ituA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		5 / 12 ASP A 195
GLY A 123
GLY A  19
SER A 218
GLY A 127
 None
 0.87A 4blvB-1ituA:
undetectable		 4blvB-1ituA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		5 / 12 ASP A 195
GLY A 123
GLY A  19
SER A 218
LEU A 140
 None
 1.13A 4blvB-1ituA:
undetectable		 4blvB-1ituA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		5 / 12 THR A 149
ARG A 229
ASN A 231
HIS A 152
TRP A 162
 None
None
None
CIL  A 451 (-4.0A)
None
 1.31A 4c49D-1ituA:
0.0		 4c49D-1ituA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		3 / 3 SER A 218
TYR A 147
ASP A  22
 None
None
ZN  A 401 ( 2.2A)
 0.70A 4rp8C-1ituA:
0.0		 4rp8C-1ituA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 6 TYR A 141
GLU A 338
LEU A 121
PHE A 334
 None
 1.30A 4twdD-1ituA:
0.0
4twdE-1ituA:
0.0		 4twdD-1ituA:
21.91
4twdE-1ituA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 6 TYR A 141
GLU A 338
LEU A 121
PHE A 334
 None
 1.28A 4twdF-1ituA:
0.0
4twdG-1ituA:
0.0		 4twdF-1ituA:
21.91
4twdG-1ituA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		3 / 3 VAL A  60
LEU A  55
VAL A 118
 None
 0.56A 4wq4A-1ituA:
undetectable		 4wq4A-1ituA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 5 TYR A 305
PHE A 113
LEU A 330
PRO A  15
 None
 1.46A 5csyB-1ituA:
3.6		 5csyB-1ituA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		3 / 3 GLU A 125
TRP A 162
ASN A 250
 ZN  A 401 ( 2.5A)
None
CIL  A 451 ( 4.7A)
 0.58A 5dv4A-1ituA:
0.6		 5dv4A-1ituA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		3 / 3 LEU A 208
LEU A 196
ARG A 182
 None
 0.64A 5hnzB-1ituA:
undetectable		 5hnzB-1ituA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		5 / 12 LEU A 148
LEU A 187
PHE A 179
THR A 156
ALA A 159
 None
 1.32A 5ieoA-1ituA:
0.0		 5ieoA-1ituA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 7 GLY A 287
VAL A  60
ILE A  17
VAL A  16
 None
 0.77A 5ik1A-1ituA:
undetectable		 5ik1A-1ituA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		5 / 12 VAL A 247
LEU A 246
GLY A 279
ALA A 278
LEU A 237
 None
 1.30A 5iktB-1ituA:
0.0		 5iktB-1ituA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 7 LEU A 196
VAL A 201
ILE A 274
VAL A 232
 None
 1.11A 5jh7C-1ituA:
undetectable		 5jh7C-1ituA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 8 LEU A 330
ILE A 109
PHE A 334
ALA A 119
 None
 1.01A 5m0oC-1ituA:
undetectable		 5m0oC-1ituA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		5 / 12 GLY A  61
LYS A 117
VAL A 267
LEU A 271
GLY A 286
 None
 1.15A 5vooD-1ituA:
5.4		 5vooD-1ituA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 1itu RENAL DIPEPTIDASE
(Homo
sapiens) 		4 / 7 TRP A  25
SER A  66
HIS A 152
GLY A 126
 CIL  A 451 ( 4.4A)
ZN  A 401 ( 3.7A)
CIL  A 451 (-4.0A)
None
 1.03A 6btxA-1ituA:
undetectable		 6btxA-1ituA:
21.37