SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1itv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KF6_B_ACTB704_0 (FUMARATE REDUCTASE FLAVOPROTEIN FUMARATE REDUCTASE IRON-SULFUR PROTEIN)	1itv	MMP9 (Homo sapiens)	3 / 3	ARG A 119 GLY A 95 ASP A 97	None	0.36A	1kf6A-1itvA: undetectable 1kf6B-1itvA: 0.0	1kf6A-1itvA: 15.81 1kf6B-1itvA: 19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L2I_B_CCSB417_0 (ESTROGEN RECEPTOR)	1itv	MMP9 (Homo sapiens)	4 / 6	PRO A 38 PHE A 30 GLN A 191 VAL A 185	None	1.34A	1l2iB-1itvA: undetectable	1l2iB-1itvA: 18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D4N_C_ACTC201_0 (NITROGEN REGULATORY PROTEIN P-II)	1itv	MMP9 (Homo sapiens)	4 / 5	VAL A 138 VAL A 145 GLY A 144 PHE A 161	None	1.12A	5d4nA-1itvA: undetectable 5d4nC-1itvA: undetectable	5d4nA-1itvA: 20.73 5d4nC-1itvA: 20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VCV_A_1N1A404_2 (MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE)	1itv	MMP9 (Homo sapiens)	4 / 5	VAL A 6 HIS A 150 LEU A 190 ASP A 10	SO4 A 196 ( 3.9A) None None None	1.37A	5vcvA-1itvA: undetectable	5vcvA-1itvA: 22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AUU_A_ACTA804_0 (NITRIC OXIDE SYNTHASE, BRAIN)	1itv	MMP9 (Homo sapiens)	3 / 3	GLN A 163 TRP A 168 VAL A 145	None	1.15A	6auuA-1itvA: 0.0	6auuA-1itvA: 18.12

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KF6_B_ACTB704_0","FUMARATE REDUCTASE FLAVOPROTEIN;FUMARATE REDUCTASE IRON-SULFUR PROTEIN","1itv","MMP9","Homo sapiens",3,"ARG A 119;GLY A  95;ASP A  97","None","0.36A","1kf6A-1itvA:undetectable;1kf6B-1itvA:0.0","1kf6A-1itvA:15.81;1kf6B-1itvA:19.76"],["1L2I_B_CCSB417_0","ESTROGEN RECEPTOR","1itv","MMP9","Homo sapiens",4,"PRO A  38;PHE A  30;GLN A 191;VAL A 185","None","1.34A","1l2iB-1itvA:undetectable","1l2iB-1itvA:18.87"],["5D4N_C_ACTC201_0","NITROGEN REGULATORY PROTEIN P-II","1itv","MMP9","Homo sapiens",4,"VAL A 138;VAL A 145;GLY A 144;PHE A 161","None","1.12A","5d4nA-1itvA:undetectable;5d4nC-1itvA:undetectable","5d4nA-1itvA:20.73;5d4nC-1itvA:20.73"],["5VCV_A_1N1A404_2","MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE","1itv","MMP9","Homo sapiens",4,"VAL A   6;HIS A 150;LEU A 190;ASP A  10","SO4 A 196 ( 3.9A);None;None;None","1.37A","5vcvA-1itvA:undetectable","5vcvA-1itvA:22.44"],["6AUU_A_ACTA804_0","NITRIC OXIDE SYNTHASE, BRAIN","1itv","MMP9","Homo sapiens",3,"GLN A 163;TRP A 168;VAL A 145","None","1.15A","6auuA-1itvA:0.0","6auuA-1itvA:18.12"]]