SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1itz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 1itz TRANSKETOLASE
(Zea
mays) 		3 / 3 TRP A 293
ARG A 104
THR A 297
 None
 0.93A 1df7A-1itzA:
0.3		 1df7A-1itzA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 8 GLY A 427
HIS A 424
ALA A 179
ILE A 429
 None
 0.83A 1gtnP-1itzA:
undetectable
1gtnQ-1itzA:
undetectable		 1gtnP-1itzA:
7.56
1gtnQ-1itzA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 GLY A 425
GLY A 427
GLY A 174
ALA A 179
VAL A 137
 None
 1.24A 1jg2A-1itzA:
undetectable		 1jg2A-1itzA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 11 LEU A 531
VAL A 471
LEU A 376
GLN A 373
HIS A 538
 None
 1.45A 1kt6A-1itzA:
undetectable		 1kt6A-1itzA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 11 GLN A 131
CYH A 430
ILE A 429
ALA A 134
ALA A 391
 None
 1.22A 1n4hA-1itzA:
0.0		 1n4hA-1itzA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 11 ILE A  23
ALA A  46
GLY A  44
ASN A 230
TYR A 235
 None
 1.35A 1n6cA-1itzA:
undetectable		 1n6cA-1itzA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1itz TRANSKETOLASE
(Zea
mays) 		3 / 3 ARG A 310
VAL A 304
TRP A 308
 None
 0.88A 1qw6A-1itzA:
0.0		 1qw6A-1itzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1itz TRANSKETOLASE
(Zea
mays) 		3 / 3 ARG A 310
VAL A 304
TRP A 308
 None
 0.90A 1qwcA-1itzA:
0.9		 1qwcA-1itzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 ALA A 380
THR A 339
SER A 342
ILE A 343
LEU A 146
 None
 1.13A 1rg7A-1itzA:
undetectable		 1rg7A-1itzA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1itz TRANSKETOLASE
(Zea
mays) 		3 / 3 ARG A 310
VAL A 304
TRP A 308
 None
 0.93A 1vagA-1itzA:
0.0		 1vagA-1itzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1itz TRANSKETOLASE
(Zea
mays) 		3 / 3 ARG A 310
VAL A 304
TRP A 308
 None
 0.94A 1zviA-1itzA:
2.4		 1zviA-1itzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 LEU A 141
ILE A 433
GLY A 388
PHE A 419
ASP A 406
 None
 1.06A 1zz1C-1itzA:
undetectable		 1zz1C-1itzA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 11 GLY A 571
GLU A 573
LEU A 539
ILE A 663
ALA A 626
 None
 1.50A 2a58A-1itzA:
4.3
2a58E-1itzA:
3.6		 2a58A-1itzA:
13.92
2a58E-1itzA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 11 ILE A 663
ALA A 626
GLY A 571
GLU A 573
LEU A 539
 None
 1.50A 2a58C-1itzA:
3.7
2a58D-1itzA:
4.9		 2a58C-1itzA:
13.92
2a58D-1itzA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 6 SER A 623
GLY A 569
THR A 570
ARG A 505
 None
 1.25A 2f7fA-1itzA:
2.8		 2f7fA-1itzA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 7 ALA A 445
GLY A 427
ILE A 429
PRO A 442
 None
 0.87A 2fxdB-1itzA:
undetectable		 2fxdB-1itzA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 11 ALA A 134
CYH A 430
GLY A 432
ILE A 433
VAL A 417
 None
 1.11A 2uxpB-1itzA:
1.1		 2uxpB-1itzA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 10 ASP A  99
SER A  19
ILE A  23
THR A 110
GLY A  91
 None
 1.39A 2v0mA-1itzA:
0.0		 2v0mA-1itzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 8 LEU A 254
PRO A 252
ALA A 183
ALA A 136
 None
 0.84A 2vcvF-1itzA:
undetectable		 2vcvF-1itzA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 9 ILE A  28
ALA A 281
VAL A 284
GLU A 285
 None
 0.72A 2vufA-1itzA:
0.0		 2vufA-1itzA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 LEU A 146
LEU A 139
GLY A 432
PHE A  67
VAL A 468
 None
 1.36A 2w8yA-1itzA:
undetectable		 2w8yA-1itzA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 ALA A 457
GLY A 138
GLY A 425
ILE A 175
LEU A 141
 None
 0.99A 2x1lB-1itzA:
2.5		 2x1lB-1itzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 1itz TRANSKETOLASE
(Zea
mays) 		3 / 3 MET A  43
VAL A  51
GLU A  17
 None
 0.89A 2x9gA-1itzA:
undetectable		 2x9gA-1itzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 ALA A 577
GLY A 569
THR A 570
GLY A 571
LEU A 584
 None
 1.00A 2y7hB-1itzA:
undetectable		 2y7hB-1itzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 ALA A 577
GLY A 569
THR A 570
GLY A 571
LEU A 584
 None
 1.01A 2y7hC-1itzA:
undetectable		 2y7hC-1itzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 8 GLY A 262
VAL A 274
LEU A 279
PRO A  39
 None
 0.96A 3bgdB-1itzA:
undetectable		 3bgdB-1itzA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 GLY A 569
GLY A 571
LEU A 502
ASN A 522
VAL A 518
 None
 0.88A 3elwA-1itzA:
2.2		 3elwA-1itzA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 ASN A 198
PRO A 111
GLY A  77
ASP A 196
ILE A 165
 MG  A1001 ( 2.7A)
None
None
None
None
 1.28A 3iv6A-1itzA:
2.7		 3iv6A-1itzA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 LEU A 492
GLY A 569
GLY A 571
LEU A 539
ILE A 554
 None
 0.98A 3ku1A-1itzA:
2.3		 3ku1A-1itzA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1itz TRANSKETOLASE
(Zea
mays) 		6 / 11 ALA A 445
PHE A 419
ILE A 433
LEU A 141
VAL A 417
THR A 446
 None
 1.49A 3n0hA-1itzA:
undetectable		 3n0hA-1itzA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 7 GLY A 439
SER A 437
LEU A 340
PHE A  67
HIS A 436
 None
 1.44A 3o9mA-1itzA:
undetectable		 3o9mA-1itzA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 ALA A 134
GLY A 132
GLY A 432
ALA A 176
HIS A 424
 None
 0.93A 3ou6B-1itzA:
2.4		 3ou6B-1itzA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 ALA A 134
GLY A 132
GLY A 432
ALA A 176
HIS A 424
 None
 0.90A 3ou7B-1itzA:
undetectable		 3ou7B-1itzA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1itz TRANSKETOLASE
(Zea
mays) 		6 / 12 ALA A 445
PHE A 419
ILE A 433
LEU A 141
VAL A 417
THR A 446
 None
 1.44A 3s3vA-1itzA:
undetectable		 3s3vA-1itzA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 GLY A 138
GLY A 432
LEU A 435
ALA A 183
LEU A 191
 None
 1.13A 3vywA-1itzA:
undetectable		 3vywA-1itzA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 GLY A 138
GLY A 432
LEU A 435
ALA A 183
LEU A 191
 None
 1.12A 3vywB-1itzA:
2.6		 3vywB-1itzA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 GLY A 138
GLY A 432
LEU A 435
ALA A 183
LEU A 191
 None
 1.15A 3vywD-1itzA:
2.5		 3vywD-1itzA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 11 TRP A 186
LEU A 146
ILE A 429
ILE A 433
VAL A 383
 None
 1.06A 3w67A-1itzA:
undetectable		 3w67A-1itzA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 8 LEU A 188
ASN A 135
GLY A 432
ILE A 433
 None
 0.83A 3wxoA-1itzA:
0.0		 3wxoA-1itzA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 5 ILE A 460
ALA A 462
HIS A 424
ARG A 455
 None
 1.28A 4ac9B-1itzA:
undetectable
4ac9C-1itzA:
undetectable		 4ac9B-1itzA:
21.76
4ac9C-1itzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 5 ILE A 460
ALA A 462
HIS A 424
ARG A 455
 None
 1.26A 4acaB-1itzA:
2.5
4acaC-1itzA:
undetectable		 4acaB-1itzA:
21.76
4acaC-1itzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 4 ASN A  60
ALA A 316
GLY A 315
THR A 312
 None
 1.13A 4bboC-1itzA:
0.0		 4bboC-1itzA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 6 PHE A 407
GLY A 138
LEU A 188
VAL A 137
 None
 0.95A 4dubB-1itzA:
undetectable		 4dubB-1itzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 7 ALA A 466
GLY A 427
GLY A 432
ILE A 433
 None
 0.63A 4eatA-1itzA:
2.1		 4eatA-1itzA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 8 ASP A 296
ASP A  29
ASP A 303
GLU A  97
 None
 1.09A 4feuD-1itzA:
undetectable		 4feuD-1itzA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1itz TRANSKETOLASE
(Zea
mays) 		6 / 12 ALA A 445
PHE A 419
ILE A 433
LEU A 141
VAL A 417
THR A 446
 None
 1.47A 4kfjB-1itzA:
undetectable		 4kfjB-1itzA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1itz TRANSKETOLASE
(Zea
mays) 		3 / 3 LEU A  82
ILE A  23
ARG A  24
 None
 0.69A 4mk4B-1itzA:
undetectable		 4mk4B-1itzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 8 LEU A 379
VAL A 471
LEU A 529
ILE A 469
 None
 0.77A 4r38D-1itzA:
undetectable		 4r38D-1itzA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 4 THR A 206
GLY A 167
ASP A 196
SER A 201
 None
TPP  A1002 ( 3.9A)
None
None
 1.40A 4rfqA-1itzA:
1.8		 4rfqA-1itzA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 GLY A 264
GLY A 262
PRO A  39
ASN A 270
GLU A 283
 None
 1.29A 4x61A-1itzA:
undetectable		 4x61A-1itzA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 1itz TRANSKETOLASE
(Zea
mays) 		3 / 3 VAL A 636
PHE A 596
ARG A 496
 None
 0.96A 4xr4B-1itzA:
undetectable		 4xr4B-1itzA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 4 ILE A 477
ARG A 505
TYR A 658
GLU A 573
 None
 1.39A 4zzbD-1itzA:
0.0		 4zzbD-1itzA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 8 VAL A  20
ALA A  46
GLY A  44
GLY A 231
 None
 0.74A 5e26C-1itzA:
undetectable
5e26D-1itzA:
undetectable		 5e26C-1itzA:
19.86
5e26D-1itzA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 1itz TRANSKETOLASE
(Zea
mays) 		6 / 12 GLY A 222
GLY A 189
GLY A 184
TRP A 223
ASP A  70
ILE A 192
 None
 1.47A 5e9qA-1itzA:
undetectable		 5e9qA-1itzA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 1itz TRANSKETOLASE
(Zea
mays) 		6 / 12 GLY A 222
GLY A 189
GLY A 184
TRP A 223
ASP A  70
ILE A 192
 None
 1.33A 5e9qC-1itzA:
1.6		 5e9qC-1itzA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 7 VAL A 158
LYS A 144
GLU A 143
HIS A 145
 None
 1.04A 5ecnA-1itzA:
0.8		 5ecnA-1itzA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 1itz TRANSKETOLASE
(Zea
mays) 		6 / 12 GLY A 222
GLY A 189
GLY A 184
TRP A 223
ASP A  70
ILE A 192
 None
 1.36A 5eifC-1itzA:
1.1		 5eifC-1itzA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 1itz TRANSKETOLASE
(Zea
mays) 		6 / 12 GLY A 222
GLY A 189
GLY A 184
TRP A 223
ASP A  70
ILE A 192
 None
 1.44A 5eiwC-1itzA:
undetectable		 5eiwC-1itzA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1itz TRANSKETOLASE
(Zea
mays) 		3 / 3 ARG A 310
VAL A 304
TRP A 308
 None
 0.98A 5fvoA-1itzA:
0.1		 5fvoA-1itzA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 ALA A 179
GLY A 425
GLY A 174
GLY A 138
LEU A 166
 None
 0.92A 5gwxA-1itzA:
undetectable		 5gwxA-1itzA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 8 VAL A 547
ILE A 544
ALA A 513
THR A 512
VAL A 597
 None
 1.44A 5l94A-1itzA:
undetectable		 5l94A-1itzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 10 PRO A 384
LEU A 379
PRO A 357
ALA A 513
PRO A 349
 None
 1.42A 5m0oA-1itzA:
0.0		 5m0oA-1itzA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 1itz TRANSKETOLASE
(Zea
mays) 		5 / 12 SER A 595
ALA A 507
THR A 368
ALA A 515
GLU A 548
 None
 1.16A 5vcgA-1itzA:
0.0		 5vcgA-1itzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 9 HIS A 224
ILE A 226
TYR A 161
ILE A 238
 None
 0.82A 5vkqB-1itzA:
0.0
5vkqC-1itzA:
0.0		 5vkqB-1itzA:
18.78
5vkqC-1itzA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 7 VAL A  56
PRO A  42
PHE A  72
LEU A  82
 None
 1.07A 6aycA-1itzA:
0.6		 6aycA-1itzA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 6 SER A 595
ALA A 507
THR A 368
ALA A 530
 None
 1.03A 6ma6A-1itzA:
undetectable		 6ma6A-1itzA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 1itz TRANSKETOLASE
(Zea
mays) 		4 / 7 SER A 595
ALA A 507
THR A 368
ALA A 530
 None
 0.93A 6ma7A-1itzA:
0.0		 6ma7A-1itzA:
8.29