SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iu1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1iu1 GAMMA1-ADAPTIN
(Homo
sapiens) 		5 / 12 ILE A 735
ALA A 709
PRO A 755
PHE A 758
LEU A 760
 None
 1.05A 1cd2A-1iu1A:
undetectable		 1cd2A-1iu1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1iu1 GAMMA1-ADAPTIN
(Homo
sapiens) 		5 / 12 ILE A 735
ALA A 709
PRO A 755
PHE A 758
LEU A 760
 None
 1.03A 2cd2A-1iu1A:
undetectable		 2cd2A-1iu1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1iu1 GAMMA1-ADAPTIN
(Homo
sapiens) 		5 / 7 THR A 720
GLU A 722
VAL A 732
THR A 734
VAL A 781
 None
 0.75A 3em0B-1iu1A:
2.1		 3em0B-1iu1A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1iu1 GAMMA1-ADAPTIN
(Homo
sapiens) 		5 / 8 ILE A 735
ILE A 796
SER A 767
LEU A 715
VAL A 770
 None
 1.46A 3ua5A-1iu1A:
undetectable		 3ua5A-1iu1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 1iu1 GAMMA1-ADAPTIN
(Homo
sapiens) 		3 / 3 PRO A 765
LEU A 798
SER A 768
 None
 0.78A 5fsaB-1iu1A:
undetectable		 5fsaB-1iu1A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1iu1 GAMMA1-ADAPTIN
(Homo
sapiens) 		5 / 12 ILE A 707
LEU A 762
ILE A 778
ILE A 796
LEU A 798
 None
 0.92A 5mugA-1iu1A:
undetectable		 5mugA-1iu1A:
23.21