SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iu4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1iu4 MICROBIAL
TRANSGLUTAMINASE
(Streptomyces
mobaraensis) 		4 / 7 TYR A 256
TYR A 198
GLY A  66
THR A  68
 None
 1.08A 2g70A-1iu4A:
undetectable		 2g70A-1iu4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1iu4 MICROBIAL
TRANSGLUTAMINASE
(Streptomyces
mobaraensis) 		4 / 7 TYR A 256
TYR A 198
GLY A  66
THR A  68
 None
 1.08A 2g70B-1iu4A:
undetectable		 2g70B-1iu4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 1iu4 MICROBIAL
TRANSGLUTAMINASE
(Streptomyces
mobaraensis) 		4 / 6 ARG A 307
SER A 116
PHE A  90
PRO A 220
 None
 1.29A 3jqaC-1iu4A:
undetectable		 3jqaC-1iu4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 1iu4 MICROBIAL
TRANSGLUTAMINASE
(Streptomyces
mobaraensis) 		4 / 6 ARG A 307
SER A 116
PHE A  90
PRO A 220
 None
 1.32A 3jqaD-1iu4A:
undetectable		 3jqaD-1iu4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1iu4 MICROBIAL
TRANSGLUTAMINASE
(Streptomyces
mobaraensis) 		3 / 3 HIS A 188
SER A 144
GLU A 143
 None
 0.84A 3s8pA-1iu4A:
0.0		 3s8pA-1iu4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 1iu4 MICROBIAL
TRANSGLUTAMINASE
(Streptomyces
mobaraensis) 		4 / 6 ARG A 242
GLU A 107
ARG A 100
GLU A 103
 None
 1.43A 4kr3A-1iu4A:
undetectable		 4kr3A-1iu4A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1iu4 MICROBIAL
TRANSGLUTAMINASE
(Streptomyces
mobaraensis) 		5 / 12 PRO A  99
GLU A 103
ARG A 111
ALA A 113
GLY A 218
 None
 1.10A 4oaeA-1iu4A:
undetectable		 4oaeA-1iu4A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 1iu4 MICROBIAL
TRANSGLUTAMINASE
(Streptomyces
mobaraensis) 		4 / 4 THR A 177
GLY A 186
ASP A 189
SER A 179
 None
 1.36A 4rfqA-1iu4A:
undetectable		 4rfqA-1iu4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1iu4 MICROBIAL
TRANSGLUTAMINASE
(Streptomyces
mobaraensis) 		4 / 6 TYR A  42
ASN A  71
GLU A 292
LEU A  60
 None
 1.21A 4twdB-1iu4A:
0.0
4twdC-1iu4A:
0.0		 4twdB-1iu4A:
21.56
4twdC-1iu4A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1iu4 MICROBIAL
TRANSGLUTAMINASE
(Streptomyces
mobaraensis) 		3 / 3 GLU A  28
HIS A 289
ASP A  18
 None
 0.69A 5c0oG-1iu4A:
undetectable		 5c0oG-1iu4A:
20.59