SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iu8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 110
ALA A 159
PRO A 156
THR A 149
LEU A  49
 None
 1.15A 1cbrA-1iu8A:
undetectable		 1cbrA-1iu8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 110
ALA A 159
PRO A 156
THR A 149
LEU A  49
 None
 1.15A 1cbrB-1iu8A:
undetectable		 1cbrB-1iu8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  64
ALA A 192
VAL A  75
VAL A 164
ILE A 162
 None
 1.03A 1hxbB-1iu8A:
undetectable		 1hxbB-1iu8A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A  73
ILE A 193
LEU A   5
ILE A  62
 None
 0.83A 2q83A-1iu8A:
undetectable		 2q83A-1iu8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		5 / 10 PHE A   8
ILE A 193
LEU A  50
THR A 146
GLY A   7
 None
 1.36A 2v0mA-1iu8A:
0.0		 2v0mA-1iu8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A   3
LEU A   5
LEU A  26
THR A 111
VAL A 189
 None
 1.21A 3dcjA-1iu8A:
2.7
3dcjB-1iu8A:
3.3		 3dcjA-1iu8A:
22.57
3dcjB-1iu8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A  64
ALA A 142
THR A 146
ALA A 159
THR A  61
 None
 1.23A 3mdtA-1iu8A:
0.0		 3mdtA-1iu8A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  64
ALA A 192
VAL A  75
VAL A 164
ILE A 162
 None
 1.01A 3mwsB-1iu8A:
undetectable		 3mwsB-1iu8A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  64
ALA A 192
VAL A  75
VAL A 164
ILE A 162
 None
 1.03A 3pwmA-1iu8A:
undetectable		 3pwmA-1iu8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		4 / 5 ALA A  79
ILE A 100
LEU A 145
ASN A 140
 None
 1.22A 4g19A-1iu8A:
0.7		 4g19A-1iu8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A  22
LEU A   5
ILE A 191
GLY A 160
 None
 0.85A 4hb6A-1iu8A:
undetectable		 4hb6A-1iu8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		5 / 8 LEU A   4
LEU A  53
LEU A  49
ALA A 142
LEU A  38
 None
 1.06A 4z90A-1iu8A:
1.1
4z90B-1iu8A:
0.0
4z90C-1iu8A:
0.0
4z90D-1iu8A:
1.1
4z90E-1iu8A:
1.2		 4z90A-1iu8A:
21.26
4z90B-1iu8A:
21.26
4z90C-1iu8A:
21.26
4z90D-1iu8A:
21.26
4z90E-1iu8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		5 / 8 LEU A  49
ALA A 142
LEU A  38
LEU A   4
LEU A  53
 None
 1.07A 4z90A-1iu8A:
1.1
4z90B-1iu8A:
0.0
4z90C-1iu8A:
0.0
4z90D-1iu8A:
1.1
4z90E-1iu8A:
1.2		 4z90A-1iu8A:
21.26
4z90B-1iu8A:
21.26
4z90C-1iu8A:
21.26
4z90D-1iu8A:
21.26
4z90E-1iu8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 193
LEU A 200
GLY A  35
LEU A  64
THR A   6
 None
 1.01A 5byjA-1iu8A:
2.9		 5byjA-1iu8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A 112
THR A 114
VAL A  75
VAL A 195
 None
 0.91A 5eclD-1iu8A:
0.6		 5eclD-1iu8A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		5 / 9 ILE A 112
VAL A 164
LEU A  64
ILE A  22
LEU A 147
 None
 1.48A 5iepA-1iu8A:
undetectable		 5iepA-1iu8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  64
ALA A 192
VAL A  75
VAL A 164
ILE A 162
 None
 0.99A 5kqyA-1iu8A:
undetectable		 5kqyA-1iu8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		5 / 7 GLY A  35
LEU A   4
GLY A   7
LEU A  64
ILE A 117
 None
 1.12A 5vkqA-1iu8A:
undetectable
5vkqB-1iu8A:
undetectable		 5vkqA-1iu8A:
8.86
5vkqB-1iu8A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1iu8 PYRROLIDONE-CARBOXYL
ATE PEPTIDASE
(Pyrococcus
horikoshii) 		5 / 8 GLY A  35
LEU A   4
GLY A   7
LEU A  64
ILE A 117
 None
 1.11A 5vkqB-1iu8A:
undetectable
5vkqC-1iu8A:
undetectable		 5vkqB-1iu8A:
8.86
5vkqC-1iu8A:
8.86