SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 10 GLU A 244
ALA A  39
LEU A  43
LEU A 165
GLU A 245
 None
 1.25A 1a29A-1iugA:
undetectable		 1a29A-1iugA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ALA A 202
LEU A 206
LEU A 198
LEU A  54
ALA A  66
 None
 1.15A 1h9zA-1iugA:
undetectable		 1h9zA-1iugA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ALA A 202
THR A  49
VAL A  53
ALA A  63
LEU A  71
 None
 1.01A 1jinA-1iugA:
undetectable		 1jinA-1iugA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ALA A 202
THR A  49
VAL A  53
LEU A  54
ALA A  63
 None
 0.80A 1jinA-1iugA:
undetectable		 1jinA-1iugA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 PHE A 195
LEU A 187
LEU A 243
 None
 0.59A 1mx1E-1iugA:
undetectable		 1mx1E-1iugA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 9 THR A 134
SER A  87
GLU A 131
ARG A 103
ASP A 105
 None
 1.49A 1nb9A-1iugA:
undetectable		 1nb9A-1iugA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A 336
VAL A 267
LEU A 325
SER A 324
LEU A 263
 None
 1.06A 1ya4C-1iugA:
undetectable		 1ya4C-1iugA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 7 SER A 130
SER A 281
SER A 163
THR A 162
 None
None
None
LLP  A 185 ( 3.4A)
 1.06A 2i91A-1iugA:
3.9		 2i91A-1iugA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 7 SER A 130
SER A 281
SER A 163
THR A 162
 None
None
None
LLP  A 185 ( 3.4A)
 1.06A 2i91B-1iugA:
3.7		 2i91B-1iugA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 LYS A 119
LEU A  79
ALA A 118
LEU A 125
 None
 1.33A 2roxA-1iugA:
undetectable		 2roxA-1iugA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 LEU A  25
ARG A  22
ILE A 233
 None
 0.62A 2xn5B-1iugA:
0.0		 2xn5B-1iugA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 TYR A  83
VAL A 128
THR A 111
 None
 0.80A 2ygnA-1iugA:
undetectable		 2ygnA-1iugA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 SER A  59
GLY A  60
THR A  61
 LLP  A 185 ( 2.8A)
LLP  A 185 ( 3.7A)
LLP  A 185 ( 3.6A)
 0.21A 3k9wA-1iugA:
2.0		 3k9wA-1iugA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 LEU A 263
TRP A   3
MET A 340
TYR A 332
 None
 1.32A 3mnoA-1iugA:
0.0		 3mnoA-1iugA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 LEU A 263
TRP A   3
MET A 340
TYR A 332
 None
 1.31A 3mnpA-1iugA:
0.0		 3mnpA-1iugA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 PRO A 275
TYR A 265
GLY A 268
 None
 0.56A 4g2zA-1iugA:
undetectable		 4g2zA-1iugA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ALA A 202
LEU A  67
ALA A  66
LYS A  69
LEU A  99
 None
 1.02A 4psyA-1iugA:
undetectable		 4psyA-1iugA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 193
SER A 183
VAL A 239
ALA A 238
LEU A  20
 None
 1.10A 4rrwA-1iugA:
undetectable		 4rrwA-1iugA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 193
SER A 183
VAL A 239
ALA A 238
LEU A  20
 None
 1.10A 4rrwB-1iugA:
0.0		 4rrwB-1iugA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 193
SER A 183
VAL A 239
ALA A 238
LEU A  20
 None
 1.09A 4rrwC-1iugA:
0.0		 4rrwC-1iugA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 193
SER A 183
VAL A 239
ALA A 238
LEU A  20
 None
 1.10A 4rrzA-1iugA:
undetectable		 4rrzA-1iugA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 193
SER A 183
VAL A 239
ALA A 238
LEU A  20
 None
 1.10A 4rrzB-1iugA:
0.0		 4rrzB-1iugA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 193
SER A 183
VAL A 239
ALA A 238
LEU A  20
 None
 1.09A 4rrzC-1iugA:
0.0		 4rrzC-1iugA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 LEU A 127
PRO A  81
GLU A 131
TYR A  83
 None
 1.13A 4z4gA-1iugA:
0.0		 4z4gA-1iugA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A   8
TYR A 265
LEU A 264
PHE A 341
THR A   6
 LLP  A 185 ( 3.5A)
None
None
None
None
 1.16A 4ze2A-1iugA:
0.0		 4ze2A-1iugA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 8 ALA A 286
VAL A 320
GLY A 135
ALA A 136
GLY A 109
 None
 1.09A 4zjzB-1iugA:
2.9		 4zjzB-1iugA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 9 ALA A 232
LEU A  56
GLY A  58
LEU A 193
GLU A 218
 None
 1.16A 5dqfA-1iugA:
0.0		 5dqfA-1iugA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A   8
TYR A 265
LEU A 264
PHE A 341
THR A   6
 LLP  A 185 ( 3.5A)
None
None
None
None
 1.12A 5eskA-1iugA:
undetectable		 5eskA-1iugA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 ILE A 348
PRO A 290
LEU A 323
TYR A 295
 None
 0.97A 5ieoA-1iugA:
0.0		 5ieoA-1iugA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 193
SER A 183
VAL A 239
ALA A 238
LEU A  20
 None
 1.15A 5ikrA-1iugA:
0.0		 5ikrA-1iugA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLU A 270
LEU A 264
GLY A 339
MET A 340
PHE A 321
 None
 1.22A 5kc0A-1iugA:
0.0		 5kc0A-1iugA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 VAL A 276
ALA A 285
PRO A 315
ALA A 286
GLY A 135
 None
 1.38A 5tzoA-1iugA:
undetectable		 5tzoA-1iugA:
16.81