SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iuh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 1iuh 2'-5' RNA LIGASE
(Thermus
thermophilus) 		4 / 5 LEU A  59
GLU A 111
ALA A 107
LEU A 105
 None
 1.15A 1eta1-1iuhA:
0.0		 1eta1-1iuhA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 1iuh 2'-5' RNA LIGASE
(Thermus
thermophilus) 		4 / 5 LEU A  59
GLU A 111
ALA A 107
LEU A 105
 None
 1.15A 1eta2-1iuhA:
undetectable		 1eta2-1iuhA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 1iuh 2'-5' RNA LIGASE
(Thermus
thermophilus) 		4 / 6 LEU A  59
GLU A 111
ALA A 107
LEU A 105
 None
 1.12A 1etb1-1iuhA:
undetectable		 1etb1-1iuhA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 1iuh 2'-5' RNA LIGASE
(Thermus
thermophilus) 		4 / 6 LEU A  59
GLU A 111
ALA A 107
LEU A 105
 None
 1.08A 1etb2-1iuhA:
undetectable		 1etb2-1iuhA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1iuh 2'-5' RNA LIGASE
(Thermus
thermophilus) 		3 / 3 GLU A  12
GLU A  19
LEU A  38
 None
 0.61A 1v8bA-1iuhA:
undetectable		 1v8bA-1iuhA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1iuh 2'-5' RNA LIGASE
(Thermus
thermophilus) 		3 / 3 GLU A  12
GLU A  19
LEU A  38
 None
 0.60A 1v8bB-1iuhA:
undetectable		 1v8bB-1iuhA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 1iuh 2'-5' RNA LIGASE
(Thermus
thermophilus) 		5 / 10 LEU A  42
PHE A   8
ALA A 158
PHE A 157
GLY A 156
 None
 1.44A 3qpsA-1iuhA:
0.6		 3qpsA-1iuhA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1iuh 2'-5' RNA LIGASE
(Thermus
thermophilus) 		4 / 7 GLY A 108
ALA A 107
ALA A 102
ARG A 106
 None
 0.88A 3ur0B-1iuhA:
undetectable		 3ur0B-1iuhA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1iuh 2'-5' RNA LIGASE
(Thermus
thermophilus) 		5 / 12 LEU A  17
LEU A 133
ILE A 131
GLY A  76
LEU A  74
 None
 1.03A 4lmnA-1iuhA:
undetectable		 4lmnA-1iuhA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1iuh 2'-5' RNA LIGASE
(Thermus
thermophilus) 		5 / 12 LEU A  17
LEU A  74
PHE A  70
LEU A  40
ILE A 131
 None
 1.07A 4x1fA-1iuhA:
0.0		 4x1fA-1iuhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1iuh 2'-5' RNA LIGASE
(Thermus
thermophilus) 		5 / 12 LEU A  17
LEU A  74
PHE A  70
LEU A  40
ILE A 131
 None
 1.08A 4x1gA-1iuhA:
0.0		 4x1gA-1iuhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1iuh 2'-5' RNA LIGASE
(Thermus
thermophilus) 		4 / 8 ALA A  72
LEU A 101
LEU A  42
LEU A 179
 None
 0.72A 5jqbA-1iuhA:
undetectable
5jqbB-1iuhA:
undetectable		 5jqbA-1iuhA:
20.97
5jqbB-1iuhA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 1iuh 2'-5' RNA LIGASE
(Thermus
thermophilus) 		3 / 3 HIS A 130
LYS A  92
PHE A  90
 None
 1.43A 5klaA-1iuhA:
undetectable		 5klaA-1iuhA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1iuh 2'-5' RNA LIGASE
(Thermus
thermophilus) 		3 / 3 LYS A 125
PRO A 126
LYS A 128
 None
 0.68A 5y9yA-1iuhA:
0.0		 5y9yA-1iuhA:
20.49