SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iuq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		5 / 10 LEU A 135
GLN A 140
LEU A 345
THR A 163
PHE A 165
 None
 1.18A 1zucA-1iuqA:
undetectable		 1zucA-1iuqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		5 / 12 LEU A 135
GLN A 140
LEU A 345
THR A 163
PHE A 165
 None
 1.20A 1zucB-1iuqA:
undetectable		 1zucB-1iuqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		5 / 12 LEU A 274
LEU A 305
LEU A 152
ALA A 160
ILE A 159
 None
 1.03A 2bxpA-1iuqA:
3.2		 2bxpA-1iuqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		4 / 6 LEU A  41
TYR A  45
ILE A 298
GLY A  99
 None
 0.85A 2du8A-1iuqA:
undetectable		 2du8A-1iuqA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		4 / 6 LEU A  41
TYR A  45
ILE A 298
GLY A  99
 None
 0.90A 2du8B-1iuqA:
undetectable		 2du8B-1iuqA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		6 / 12 LEU A 135
GLN A 140
LEU A 345
LEU A 151
THR A 163
PHE A 165
 None
 1.44A 2oaxA-1iuqA:
0.8		 2oaxA-1iuqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		6 / 12 LEU A 135
GLN A 140
LEU A 345
LEU A 151
THR A 163
PHE A 165
 None
 1.34A 2oaxB-1iuqA:
undetectable		 2oaxB-1iuqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		5 / 12 LEU A 135
GLN A 140
LEU A 345
LEU A 151
PHE A 165
 None
 1.25A 2oaxD-1iuqA:
undetectable		 2oaxD-1iuqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		5 / 8 LEU A  69
VAL A  34
LEU A  30
VAL A  76
LEU A  73
 None
 1.24A 3kp6A-1iuqA:
undetectable
3kp6B-1iuqA:
undetectable		 3kp6A-1iuqA:
17.65
3kp6B-1iuqA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		5 / 12 GLY A 304
GLY A 302
ASN A 301
ALA A 275
LEU A 345
 None
 0.98A 3p2kC-1iuqA:
undetectable		 3p2kC-1iuqA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		5 / 12 GLN A 140
LEU A 345
LEU A 151
THR A 163
PHE A 165
 None
 1.42A 3vhuA-1iuqA:
undetectable		 3vhuA-1iuqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		5 / 12 LEU A 135
GLN A 140
LEU A 345
THR A 163
PHE A 165
 None
 1.18A 3vhuA-1iuqA:
undetectable		 3vhuA-1iuqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		5 / 12 VAL A  11
SER A   5
ILE A  21
LEU A  30
VAL A  76
 None
 0.95A 3w67C-1iuqA:
0.0		 3w67C-1iuqA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		5 / 10 LEU A 274
LEU A 305
LEU A 152
THR A 163
LEU A 135
 None
 0.97A 4z91A-1iuqA:
0.0
4z91B-1iuqA:
0.0
4z91C-1iuqA:
0.0
4z91D-1iuqA:
0.0
4z91E-1iuqA:
0.0		 4z91A-1iuqA:
21.93
4z91B-1iuqA:
21.93
4z91C-1iuqA:
21.93
4z91D-1iuqA:
21.93
4z91E-1iuqA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		3 / 3 LEU A 151
PHE A 120
ILE A 148
 None
 0.72A 5dzk1-1iuqA:
undetectable
5dzkF-1iuqA:
0.0
5dzkM-1iuqA:
0.0		 5dzk1-1iuqA:
11.76
5dzkF-1iuqA:
20.16
5dzkM-1iuqA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		3 / 3 VAL A 307
HIS A 270
VAL A 133
 None
 0.65A 5jmnC-1iuqA:
0.0		 5jmnC-1iuqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		5 / 8 LEU A 151
ILE A 147
ILE A 281
ASN A 301
SER A 350
 None
 1.47A 5numA-1iuqA:
undetectable		 5numA-1iuqA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		5 / 12 LEU A 213
SER A 191
VAL A 189
TRP A 228
GLY A 168
 None
 1.16A 5tzoB-1iuqA:
undetectable		 5tzoB-1iuqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		5 / 12 PHE A  82
ASP A  75
ILE A 103
THR A 163
ALA A  88
 None
GOL  A1002 (-3.7A)
None
None
None
 1.25A 5vcgA-1iuqA:
undetectable		 5vcgA-1iuqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		4 / 5 LEU A 213
LYS A 214
ALA A 217
LEU A 220
 None
 0.54A 5vkqA-1iuqA:
0.0
5vkqD-1iuqA:
0.0		 5vkqA-1iuqA:
12.42
5vkqD-1iuqA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		4 / 5 LEU A 213
LYS A 214
ALA A 217
LEU A 220
 None
 0.53A 5vkqA-1iuqA:
0.0
5vkqB-1iuqA:
0.0		 5vkqA-1iuqA:
12.42
5vkqB-1iuqA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		4 / 5 LEU A 213
LYS A 214
ALA A 217
LEU A 220
 None
 0.52A 5vkqB-1iuqA:
0.0
5vkqC-1iuqA:
0.0		 5vkqB-1iuqA:
12.42
5vkqC-1iuqA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		4 / 5 LEU A 213
LYS A 214
ALA A 217
LEU A 220
 None
 0.53A 5vkqC-1iuqA:
0.0
5vkqD-1iuqA:
0.0		 5vkqC-1iuqA:
12.42
5vkqD-1iuqA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Cucurbita
moschata) 		4 / 8 ILE A 123
LEU A 135
LEU A 276
ALA A 275
 None
 0.87A 5y7pE-1iuqA:
0.0		 5y7pE-1iuqA:
23.72