SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ivh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 ILE A  39
GLY A 218
LEU A 265
LEU A 370
TYR A 371
 None
None
None
FAD  A 399 ( 4.6A)
None
 1.07A 1fm6X-1ivhA:
undetectable		 1fm6X-1ivhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 4 LYS A 181
ALA A 180
MET A 147
 None
 1.04A 1hk3A-1ivhA:
undetectable		 1hk3A-1ivhA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 11 VAL A 311
LEU A 263
SER A  87
HIS A  79
TYR A  97
 None
 1.25A 1mmtA-1ivhA:
undetectable		 1mmtA-1ivhA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 ALA A 368
LEU A 365
GLY A 362
GLY A 346
 None
 0.79A 1rukH-1ivhA:
undetectable
1rukL-1ivhA:
undetectable		 1rukH-1ivhA:
19.59
1rukL-1ivhA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_B_NCAB508_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 5 GLN A  17
LEU A  81
TYR A 312
GLN A 309
 None
 1.30A 1yc2B-1ivhA:
0.0
1yc2C-1ivhA:
0.0		 1yc2B-1ivhA:
23.31
1yc2C-1ivhA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 LEU A  55
ILE A  86
ALA A 375
ILE A 332
 None
None
COS  A 400 (-4.8A)
None
 0.71A 2xkwA-1ivhA:
0.0		 2xkwA-1ivhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 SER A 101
GLY A  94
LEU A 253
ASN A 106
ASP A 252
 None
None
None
None
COS  A 400 (-3.6A)
 1.40A 3r24A-1ivhA:
undetectable		 3r24A-1ivhA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 GLY A  71
GLY A  62
VAL A 109
HIS A 100
 None
 0.77A 4c5nC-1ivhA:
undetectable		 4c5nC-1ivhA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 ASN A 357
ASP A  40
ASP A 212
 None
 0.71A 4obwD-1ivhA:
undetectable		 4obwD-1ivhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 LEU A 247
LEU A 108
ASN A 102
 None
 0.75A 4otwA-1ivhA:
undetectable		 4otwA-1ivhA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 9 ALA A 339
ALA A 343
GLY A 260
GLY A 261
ASP A 367
 None
 1.15A 4qwuK-1ivhA:
undetectable
4qwuL-1ivhA:
undetectable		 4qwuK-1ivhA:
21.71
4qwuL-1ivhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 ALA A 268
ILE A 332
ALA A 259
GLY A 261
GLU A  85
 None
 1.12A 4r29D-1ivhA:
2.7		 4r29D-1ivhA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 4 THR A 168
GLY A  91
ASP A 367
SER A  96
 FAD  A 399 (-4.0A)
None
None
None
 1.26A 4rfqA-1ivhA:
undetectable		 4rfqA-1ivhA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 LYS A 164
ILE A 193
LYS A 181
VAL A 244
 None
None
None
COS  A 400 (-4.4A)
 1.13A 4tvtA-1ivhA:
0.0		 4tvtA-1ivhA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 THR A 168
ALA A  99
ASN A 169
 FAD  A 399 (-4.0A)
FAD  A 399 ( 4.8A)
None
 0.38A 5ersA-1ivhA:
undetectable		 5ersA-1ivhA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 10 VAL A 175
ASP A 174
LEU A 103
GLY A 127
LEU A  61
 None
 1.26A 5m5cE-1ivhA:
undetectable		 5m5cE-1ivhA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 GLY A  94
GLY A 261
PRO A 262
GLY A 264
 None
 0.69A 6ag0C-1ivhA:
undetectable		 6ag0C-1ivhA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 9 ASN A 169
SER A  96
SER A 126
GLY A  56
THR A  64
 None
 1.37A 6awpA-1ivhA:
1.1		 6awpA-1ivhA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 11 VAL A  80
ALA A 259
LEU A  13
ASP A   7
LEU A 256
 None
 1.44A 6dk1B-1ivhA:
0.0		 6dk1B-1ivhA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 10 TRP A  52
GLY A  70
LEU A  61
GLY A  59
LEU A 370
 None
None
None
None
FAD  A 399 ( 4.6A)
 1.20A 6hqbA-1ivhA:
5.0
6hqbJ-1ivhA:
0.0		 6hqbA-1ivhA:
11.65
6hqbJ-1ivhA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 9 ILE A 332
ALA A 259
GLY A 260
CYH A 328
ARG A 381
 None
 1.35A 6nm4B-1ivhA:
undetectable		 6nm4B-1ivhA:
19.44