SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iwl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN
(Escherichia
coli) 		5 / 12 ALA A 142
LEU A 124
LEU A  92
PHE A  90
LEU A  59
 None
 0.89A 1bzfA-1iwlA:
undetectable		 1bzfA-1iwlA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN
(Escherichia
coli) 		3 / 3 ASP A   5
PHE A 113
ARG A   9
 None
 0.68A 2a3aA-1iwlA:
undetectable		 2a3aA-1iwlA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN
(Escherichia
coli) 		5 / 12 PHE A 127
LEU A  10
THR A 128
ILE A 129
ALA A   2
 None
 0.96A 3mdvB-1iwlA:
undetectable		 3mdvB-1iwlA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN
(Escherichia
coli) 		4 / 8 SER A  57
GLN A  53
ASN A  70
ASP A  55
 None
 1.23A 3n62B-1iwlA:
0.0		 3n62B-1iwlA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A   6
LEU A  92
GLY A  86
THR A  85
LEU A  10
 None
 0.98A 3okxA-1iwlA:
0.0		 3okxA-1iwlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A   6
LEU A  92
GLY A  86
THR A  85
LEU A  10
 None
 0.96A 3okxB-1iwlA:
0.0		 3okxB-1iwlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN
(Escherichia
coli) 		4 / 5 GLY A 135
ASP A 134
ARG A 133
GLN A 139
 None
ZN  A 193 ( 3.9A)
None
None
 1.41A 3qx3A-1iwlA:
undetectable		 3qx3A-1iwlA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN
(Escherichia
coli) 		5 / 12 ALA A 142
LEU A 115
GLY A  86
ASN A 123
ALA A  84
 None
 0.86A 4pclA-1iwlA:
undetectable		 4pclA-1iwlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN
(Escherichia
coli) 		6 / 12 ASN A  96
ILE A  93
ALA A  94
PHE A 140
VAL A 131
GLY A 132
 None
None
None
None
None
ZN  A 193 ( 4.6A)
 1.10A 5j2tC-1iwlA:
undetectable		 5j2tC-1iwlA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN
(Escherichia
coli) 		3 / 3 TRP A  49
MET A  91
ASN A  87
 None
 1.33A 5uc1B-1iwlA:
undetectable		 5uc1B-1iwlA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN
(Escherichia
coli) 		3 / 3 TRP A  49
MET A  91
ASN A  87
 None
 1.31A 5uc1A-1iwlA:
0.0		 5uc1A-1iwlA:
16.85