SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iwp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 6 ILE A  72
LYS A 113
ALA A 112
VAL A  42
 None
 0.93A 1hk1A-1iwpA:
0.0		 1hk1A-1iwpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 10 LEU A 322
LEU A  92
ILE A 109
THR A 106
ILE A 285
 None
 1.33A 1i18A-1iwpA:
0.0
1i18B-1iwpA:
0.0		 1i18A-1iwpA:
10.74
1i18B-1iwpA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 10 ILE A 285
LEU A 322
LEU A  92
ILE A 109
THR A 106
 None
 1.31A 1i18A-1iwpA:
undetectable
1i18B-1iwpA:
0.0		 1i18A-1iwpA:
10.74
1i18B-1iwpA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 6 LEU G  38
LEU A 472
GLY A 471
ILE A 490
 None
 0.88A 1mt1G-1iwpG:
undetectable
1mt1J-1iwpG:
undetectable		 1mt1G-1iwpG:
12.77
1mt1J-1iwpG:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 7 ILE A 490
LEU G  38
LEU A 472
GLY A 471
 None
 0.87A 1mt1H-1iwpA:
0.0
1mt1K-1iwpA:
0.0		 1mt1H-1iwpA:
11.05
1mt1K-1iwpA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 6 ASP A 372
GLY A 175
ILE A 176
ILE A 155
 None
 0.88A 1n49D-1iwpA:
undetectable		 1n49D-1iwpA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 8 ILE A 474
GLY A 471
GLY A 216
PRO A 181
ALA A 180
 None
 1.32A 1sguA-1iwpA:
undetectable		 1sguA-1iwpA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		3 / 3 PRO A 139
ASP A 359
ASP A 521
 None
 0.77A 1sqfA-1iwpA:
undetectable		 1sqfA-1iwpA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 GLY A 471
VAL G  37
LEU A 491
LEU A 427
LEU G  38
 None
 1.06A 1ya4C-1iwpA:
undetectable		 1ya4C-1iwpA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B0Q_A_NMYA305_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 GLU A 100
ASP A 521
SER A 517
ARG A  99
ASP A 328
 None
 1.32A 2b0qA-1iwpA:
0.0		 2b0qA-1iwpA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_B_MTXB1272_1
(PTERIDINE REDUCTASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 SER A 378
PHE A 362
ASP A 384
TYR A 365
LEU A 351
 None
 1.47A 2c7vB-1iwpA:
2.4		 2c7vB-1iwpA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_C_MTXC1272_1
(PTERIDINE REDUCTASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 SER A 261
PRO A 111
PHE A 286
LEU A 322
MET A 118
 None
 1.48A 2c7vC-1iwpA:
undetectable		 2c7vC-1iwpA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_C_MTXC1272_1
(PTERIDINE REDUCTASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 SER A 378
PHE A 362
ASP A 384
TYR A 365
LEU A 351
 None
 1.47A 2c7vC-1iwpA:
undetectable		 2c7vC-1iwpA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 7 ARG A 134
GLU A 330
ASN A 298
ALA A 324
 None
 1.01A 2ejfA-1iwpA:
0.0		 2ejfA-1iwpA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 8 ARG A 195
GLY A 163
THR A 409
ILE A 412
 None
 0.98A 2f9wA-1iwpA:
undetectable
2f9wB-1iwpA:
undetectable		 2f9wA-1iwpA:
19.08
2f9wB-1iwpA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 4 ALA G  68
VAL A 293
PHE G  73
THR A 505
 None
 1.42A 2pkkA-1iwpG:
undetectable		 2pkkA-1iwpG:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 7 ILE A 490
LEU G  38
LEU A 472
GLY A 471
 None
 0.90A 2qqcD-1iwpA:
0.0
2qqcE-1iwpA:
0.0		 2qqcD-1iwpA:
11.47
2qqcE-1iwpA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 8 ILE A 490
LEU G  38
LEU A 472
GLY A 471
 None
 0.87A 2qqcH-1iwpA:
undetectable
2qqcK-1iwpA:
0.0		 2qqcH-1iwpA:
11.47
2qqcK-1iwpA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 8 ILE A 490
LEU G  38
LEU A 472
GLY A 471
 None
 0.89A 2qqdB-1iwpA:
0.0
2qqdC-1iwpA:
undetectable		 2qqdB-1iwpA:
11.47
2qqdC-1iwpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 9 ALA A 162
ALA A 416
GLY A 190
GLY A 194
ILE A 412
 None
 1.13A 2v7bA-1iwpA:
undetectable		 2v7bA-1iwpA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 9 ALA A 162
ALA A 416
GLY A 190
GLY A 194
ILE A 412
 None
 1.11A 2v7bB-1iwpA:
undetectable		 2v7bB-1iwpA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_1
(PTERIDINE REDUCTASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 SER A 378
PHE A 362
ASP A 384
TYR A 365
LEU A 351
 None
 1.43A 2x9gA-1iwpA:
2.3		 2x9gA-1iwpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_B_LYAB1270_1
(PTERIDINE REDUCTASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 SER A 261
PRO A 111
PHE A 286
LEU A 322
MET A 118
 None
 1.49A 2x9gB-1iwpA:
1.9		 2x9gB-1iwpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_B_LYAB1270_1
(PTERIDINE REDUCTASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 SER A 378
PHE A 362
ASP A 384
TYR A 365
LEU A 351
 None
 1.44A 2x9gB-1iwpA:
1.9		 2x9gB-1iwpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_C_LYAC1270_1
(PTERIDINE REDUCTASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 SER A 261
PRO A 111
PHE A 286
LEU A 322
MET A 118
 None
 1.49A 2x9gC-1iwpA:
0.7		 2x9gC-1iwpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_C_LYAC1270_1
(PTERIDINE REDUCTASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 SER A 378
PHE A 362
ASP A 384
TYR A 365
LEU A 351
 None
 1.44A 2x9gC-1iwpA:
0.7		 2x9gC-1iwpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_D_LYAD1270_1
(PTERIDINE REDUCTASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 SER A 261
PRO A 111
PHE A 286
LEU A 322
MET A 118
 None
 1.50A 2x9gD-1iwpA:
1.9		 2x9gD-1iwpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_D_LYAD1270_1
(PTERIDINE REDUCTASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 SER A 378
PHE A 362
ASP A 384
TYR A 365
LEU A 351
 None
 1.45A 2x9gD-1iwpA:
1.9		 2x9gD-1iwpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9V_C_TMQC1270_1
(PTERIDINE REDUCTASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 10 SER A 378
PHE A 362
ASP A 384
TYR A 365
LEU A 351
 None
 1.49A 2x9vC-1iwpA:
1.1		 2x9vC-1iwpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 ARG A 134
PHE A 362
GLY A 399
PRO A 139
ASP A 384
 None
 1.39A 2zznB-1iwpA:
undetectable		 2zznB-1iwpA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 GLN A 353
ALA A 324
THR A 358
GLY A 299
LEU A 278
 None
 1.42A 3aodC-1iwpA:
0.0		 3aodC-1iwpA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 6 TYR A 250
ALA A 249
LEU A 246
ALA A 207
 None
 0.92A 3b6hA-1iwpA:
0.0		 3b6hA-1iwpA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BMC_C_FOLC270_0
(PTERIDINE REDUCTASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 SER A 261
PRO A 111
PHE A 286
LEU A 322
MET A 118
 None
 1.48A 3bmcC-1iwpA:
2.3		 3bmcC-1iwpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 8 ARG A 195
ASP A 398
GLN A 392
GLU A 541
 None
 1.33A 3dh0A-1iwpA:
undetectable		 3dh0A-1iwpA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 8 PRO A 152
ALA A 156
ALA A 159
ILE A 420
 None
 0.74A 3dtuC-1iwpA:
0.0
3dtuD-1iwpA:
0.0		 3dtuC-1iwpA:
21.11
3dtuD-1iwpA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 GLY A 262
GLY A 308
GLY A 305
GLY A 264
ILE A 314
 None
 0.90A 3eluA-1iwpA:
undetectable		 3eluA-1iwpA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 GLY A 262
GLY A 308
GLY A 305
GLY A 264
ILE A 314
 None
 0.95A 3elwA-1iwpA:
undetectable		 3elwA-1iwpA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 GLY A 262
GLY A 308
GLY A 305
GLY A 264
ILE A 314
 None
 0.95A 3gczA-1iwpA:
undetectable		 3gczA-1iwpA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 VAL A 461
PHE A 182
ILE A 176
VAL A 174
VAL A 204
 None
 1.25A 3iw1A-1iwpA:
undetectable		 3iw1A-1iwpA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT
(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		3 / 3 GLY G  26
ILE G  49
VAL A 498
 None
 0.45A 3nv6A-1iwpG:
undetectable		 3nv6A-1iwpG:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 THR A 263
ILE A  72
ALA A 108
ILE A  88
ALA A  85
 None
 1.02A 3nxuB-1iwpA:
0.0		 3nxuB-1iwpA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		3 / 3 TYR A 371
ASP A 381
ASP A 387
 None
 0.85A 3ou6B-1iwpA:
undetectable		 3ou6B-1iwpA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 8 ILE A 474
ALA A 184
LEU A 188
LEU A 494
 None
 0.87A 3ozwA-1iwpA:
undetectable		 3ozwA-1iwpA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 8 ALA A 247
ASP A 238
TYR A 259
SER A 242
 None
 0.98A 3qj7A-1iwpA:
0.0
3qj7D-1iwpA:
0.0		 3qj7A-1iwpA:
17.90
3qj7D-1iwpA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 4 LEU A 255
GLY A 213
LEU A 210
GLU A 209
 None
 1.03A 3tgvB-1iwpA:
0.0		 3tgvB-1iwpA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 7 VAL A 198
GLY A 194
ILE A 412
VAL A 145
 None
 0.77A 3ufnB-1iwpA:
0.0		 3ufnB-1iwpA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT
(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		5 / 12 GLY A 292
ALA G  68
ALA G  61
VAL A 293
GLN A 294
 None
 1.28A 4df3A-1iwpA:
undetectable		 4df3A-1iwpA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT
(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		5 / 12 GLY A 292
ALA G  68
ALA G  61
VAL A 293
GLN A 294
 None
 1.29A 4df3B-1iwpA:
undetectable		 4df3B-1iwpA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 8 PRO A 240
ILE A 287
ILE A  63
ASP A  61
 None
 0.91A 4dtaB-1iwpA:
undetectable		 4dtaB-1iwpA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 9 ALA A 162
ALA A 416
GLY A 190
GLY A 194
ILE A 412
 None
 1.13A 4eatB-1iwpA:
undetectable		 4eatB-1iwpA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 4 PRO A 111
LEU A  52
ILE A  49
ARG A  57
 None
 0.89A 4f4dA-1iwpA:
undetectable		 4f4dA-1iwpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 4 LEU A 255
LEU A 212
GLN A 496
GLU A 169
 None
 1.14A 4i41A-1iwpA:
0.0		 4i41A-1iwpA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 SER A 276
VAL A 226
ALA A 316
LEU A 329
VAL A 331
 None
 1.16A 4ib4A-1iwpA:
0.4		 4ib4A-1iwpA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 10 GLU A 436
ALA A 440
ALA A 186
ALA A 156
ILE A 420
 None
 1.05A 4lbgA-1iwpA:
undetectable		 4lbgA-1iwpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 9 GLU A 436
ALA A 440
ALA A 186
ALA A 156
ILE A 420
 None
 1.06A 4lbgB-1iwpA:
undetectable		 4lbgB-1iwpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 ALA A 221
MET A 214
ALA A 249
LEU A 246
ILE G  87
 None
 1.12A 4lnwA-1iwpA:
0.0		 4lnwA-1iwpA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 ALA A 221
MET A 214
ALA A 249
LEU A 246
ILE G  87
 None
 1.12A 4lnxA-1iwpA:
0.0		 4lnxA-1iwpA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 CYH A 193
ALA A 159
ILE A 486
ALA A 419
ILE A 490
 None
 0.96A 4o2bD-1iwpA:
undetectable		 4o2bD-1iwpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 11 GLY A 400
GLY A 399
MET A 354
ILE A 542
PHE A 385
 None
 1.18A 4qoiA-1iwpA:
undetectable
4qoiB-1iwpA:
undetectable		 4qoiA-1iwpA:
19.18
4qoiB-1iwpA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		3 / 3 MET A 214
GLN A 201
TYR A 220
 None
K  A1603 ( 4.7A)
None
 0.80A 4udcA-1iwpA:
0.0		 4udcA-1iwpA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 ILE A 534
SER A 535
ASP A 398
ARG A 402
GLU A 541
 None
 1.33A 4xt8A-1iwpA:
undetectable		 4xt8A-1iwpA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT
(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		4 / 7 ASN G 120
SER A 248
ALA A 247
GLY A 292
 None
 0.88A 5fpdB-1iwpG:
undetectable		 5fpdB-1iwpG:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JDC_C_6JPC302_1
(PTERIDINE REDUCTASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 10 SER A 378
PHE A 362
ASP A 384
TYR A 365
LEU A 351
 None
 1.50A 5jdcB-1iwpA:
2.2
5jdcC-1iwpA:
0.7		 5jdcB-1iwpA:
20.91
5jdcC-1iwpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 8 TYR A 502
SER A 219
THR A 200
ILE A 490
 None
 1.02A 5jhdE-1iwpA:
undetectable
5jhdG-1iwpA:
undetectable		 5jhdE-1iwpA:
18.78
5jhdG-1iwpA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT
(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		4 / 7 ASP A 501
THR A 499
LEU G  13
VAL G   8
 None
 1.11A 5ov9A-1iwpA:
undetectable		 5ov9A-1iwpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
(Klebsiella
pneumoniae) 		5 / 12 ASN A 141
ILE A 542
GLN A 392
THR A 347
THR A 350
 None
 1.24A 6bbsA-1iwpA:
undetectable		 6bbsA-1iwpA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1iwp GLYCEROL DEHYDRATASE
GAMMA SUBUNIT
(Klebsiella
pneumoniae) 		4 / 7 LEU G  13
ASP G  10
GLN G   9
GLN G  63
 None
 1.18A 6g31D-1iwpG:
undetectable		 6g31D-1iwpG:
22.45