SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ix5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 1ix5 FKBP
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 9 TYR A  15
ASP A  26
LEU A  48
TYR A  84
PHE A 145
 None
 0.83A 1q6iA-1ix5A:
9.0		 1q6iA-1ix5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1ix5 FKBP
(Methanothermococ
cus
thermolithotroph
icus) 		4 / 5 PRO A  79
GLY A 140
ASN A  86
GLY A  85
 None
 0.99A 1zlqA-1ix5A:
undetectable		 1zlqA-1ix5A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1ix5 FKBP
(Methanothermococ
cus
thermolithotroph
icus) 		4 / 4 LYS A 141
ALA A  83
PHE A  61
GLY A  60
 None
 1.24A 2rddA-1ix5A:
0.0		 2rddA-1ix5A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 1ix5 FKBP
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 10 TYR A  15
ASP A  26
LEU A  48
TYR A  84
PHE A 145
 None
 1.03A 3kz7A-1ix5A:
10.5		 3kz7A-1ix5A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1ix5 FKBP
(Methanothermococ
cus
thermolithotroph
icus) 		4 / 6 LYS A  10
ILE A  11
VAL A  65
LEU A  66
 None
 0.99A 4em2A-1ix5A:
undetectable		 4em2A-1ix5A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1ix5 FKBP
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 11 TYR A  15
ASP A  26
LEU A  48
TYR A  84
PHE A 145
 None
 1.02A 4odrA-1ix5A:
9.4
4odrB-1ix5A:
9.4		 4odrA-1ix5A:
29.22
4odrB-1ix5A:
29.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 1ix5 FKBP
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 11 TYR A  15
ASP A  26
LEU A  48
TYR A  84
PHE A 145
 None
 0.93A 5d75A-1ix5A:
10.4		 5d75A-1ix5A:
30.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 1ix5 FKBP
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 11 TYR A  15
ASP A  26
LEU A  48
TYR A  84
PHE A 145
 None
 1.01A 5gpgA-1ix5A:
10.6		 5gpgA-1ix5A:
30.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ix5 FKBP
(Methanothermococ
cus
thermolithotroph
icus) 		5 / 9 LEU A  48
ILE A 149
GLU A 151
VAL A 153
GLU A  62
 None
 1.40A 5igzA-1ix5A:
undetectable		 5igzA-1ix5A:
21.26