SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ixk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 11 PHE A 308
ILE A 309
LEU A 297
GLY A 275
ALA A 105
 None
 1.48A 1ju6D-1ixkA:
0.0		 1ju6D-1ixkA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 5 ASP A 150
VAL A 151
SER A 176
ASP A 124
 None
 1.02A 1n2xB-1ixkA:
16.2		 1n2xB-1ixkA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 5 ALA A 261
ALA A 294
ALA A 278
GLN A 259
 None
 0.79A 2nyrB-1ixkA:
undetectable		 2nyrB-1ixkA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZE2_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A  35
TYR A  16
PRO A 251
LEU A 249
TYR A 298
 None
 1.46A 2ze2A-1ixkA:
1.9		 2ze2A-1ixkA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 127
GLY A 130
GLY A 131
VAL A 151
ASP A 152
 None
 0.85A 3m6vA-1ixkA:
34.4		 3m6vA-1ixkA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 130
GLY A 131
LYS A 132
VAL A 151
ASP A 152
 None
 0.84A 3m6vA-1ixkA:
34.4		 3m6vA-1ixkA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 127
GLY A 130
GLY A 131
VAL A 151
ASP A 152
 None
 0.85A 3m6vB-1ixkA:
34.3		 3m6vB-1ixkA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 130
GLY A 131
LYS A 132
ASP A 194
LEU A 228
 None
 1.10A 3m6vB-1ixkA:
34.3		 3m6vB-1ixkA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 130
GLY A 131
LYS A 132
VAL A 151
ASP A 152
 None
 0.86A 3m6vB-1ixkA:
34.3		 3m6vB-1ixkA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 127
GLY A 130
GLY A 131
VAL A 151
ASP A 152
 None
 0.84A 3m6wA-1ixkA:
34.4		 3m6wA-1ixkA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 130
GLY A 131
LYS A 132
VAL A 151
ASP A 152
 None
 0.88A 3m6wA-1ixkA:
34.4		 3m6wA-1ixkA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 7 GLU A 252
ILE A 218
GLU A 253
PHE A 256
 None
 0.99A 4a97A-1ixkA:
undetectable		 4a97A-1ixkA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 7 GLU A 252
ILE A 218
GLU A 253
PHE A 256
 None
 0.97A 4a97D-1ixkA:
undetectable		 4a97D-1ixkA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 130
GLY A 131
LYS A 132
ASP A 194
LEU A 228
 None
 1.04A 4fp9A-1ixkA:
25.1		 4fp9A-1ixkA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 130
GLY A 131
LYS A 132
ASP A 194
LEU A 228
 None
 1.04A 4fp9C-1ixkA:
25.0		 4fp9C-1ixkA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 130
GLY A 131
LYS A 132
ASP A 194
LEU A 228
 None
 1.04A 4fp9F-1ixkA:
25.1		 4fp9F-1ixkA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A   8
LEU A  14
GLN A  26
GLU A  30
 None
 1.11A 4i41A-1ixkA:
0.0		 4i41A-1ixkA:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 253
ARG A 213
GLU A 252
ALA A 278
GLU A 255
 None
 1.38A 4mwxA-1ixkA:
undetectable		 4mwxA-1ixkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 THR A 198
THR A 202
PHE A 307
 None
 0.89A 5cxvA-1ixkA:
undetectable		 5cxvA-1ixkA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 278
PHE A 308
GLY A 306
SER A 305
THR A 202
 None
 1.30A 5hfjE-1ixkA:
3.5		 5hfjE-1ixkA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_A_ASCA502_0
(OS09G0567300 PROTEIN)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 5 GLU A 255
PRO A 282
ARG A 296
ARG A  23
 None
 1.39A 5jcnA-1ixkA:
3.8		 5jcnA-1ixkA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 6 GLU A 255
PRO A 282
ARG A 296
ARG A  23
 None
 1.41A 5jcnB-1ixkA:
3.2		 5jcnB-1ixkA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A  63
ARG A  45
ILE A 100
PHE A  47
 None
 1.33A 5kirB-1ixkA:
0.0		 5kirB-1ixkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 6 ARG A  48
LEU A 192
PRO A 110
SER A 107
 None
 1.44A 5syjA-1ixkA:
undetectable		 5syjA-1ixkA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 6 ARG A  48
LEU A 192
PRO A 110
SER A 107
 None
 1.43A 5syjB-1ixkA:
undetectable		 5syjB-1ixkA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 5 TYR A 101
TYR A 135
GLY A 131
GLY A 130
 None
 1.22A 5x7pA-1ixkA:
2.5		 5x7pA-1ixkA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 6 TYR A 101
GLU A  78
TYR A 135
GLY A 131
GLY A 130
 None
 1.32A 5x7pB-1ixkA:
undetectable		 5x7pB-1ixkA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A  45
ILE A  89
SER A  88
 None
 0.84A 5zw2A-1ixkA:
undetectable		 5zw2A-1ixkA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 7 ASP A 194
ASP A 124
GLN A 103
TYR A 135
 None
 1.45A 6g31G-1ixkA:
undetectable		 6g31G-1ixkA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 253
ARG A 213
GLU A 252
ALA A 278
GLU A 255
 None
 1.42A 6hcxA-1ixkA:
undetectable		 6hcxA-1ixkA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1ixk METHYLTRANSFERASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A  98
GLY A 131
SER A 134
ALA A 137
 None
 0.76A 6hu9H-1ixkA:
undetectable
6hu9e-1ixkA:
undetectable		 6hu9H-1ixkA:
16.94
6hu9e-1ixkA:
19.11