SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ixl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q64_B_1UNB1001_2 (PROTEASE RETROPEPSIN)	1ixl	HYPOTHETICAL PROTEIN PH1136 (Pyrococcus horikoshii)	3 / 3	ARG A 109 THR A 78 VAL A 114	ARG A 109 ( 0.6A) THR A 78 ( 0.8A) VAL A 114 ( 0.6A)	0.89A	2q64A-1ixlA: 0.0	2q64A-1ixlA: 24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QQC_E_AG2E671_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC))	1ixl	HYPOTHETICAL PROTEIN PH1136 (Pyrococcus horikoshii)	4 / 7	GLN A 6 LEU A 61 LEU A 54 GLY A 53	GLN A 6 ( 0.6A) LEU A 61 ( 0.6A) LEU A 54 ( 0.6A) GLY A 53 ( 0.0A)	0.91A	2qqcD-1ixlA: 0.0 2qqcE-1ixlA: undetectable	2qqcD-1ixlA: 20.59 2qqcE-1ixlA: 12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OAD_A_CLMA206_0 (GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794)	1ixl	HYPOTHETICAL PROTEIN PH1136 (Pyrococcus horikoshii)	4 / 4	ALA A 55 ALA A 58 ALA A 59 ALA A 62	ALA A 55 ( 0.0A) ALA A 58 ( 0.0A) ALA A 59 ( 0.0A) ALA A 62 ( 0.0A)	0.12A	4oadA-1ixlA: 0.0	4oadA-1ixlA: 21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OAE_A_CLMA208_0 (GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794)	1ixl	HYPOTHETICAL PROTEIN PH1136 (Pyrococcus horikoshii)	4 / 4	ALA A 55 ALA A 58 ALA A 59 ALA A 62	ALA A 55 ( 0.0A) ALA A 58 ( 0.0A) ALA A 59 ( 0.0A) ALA A 62 ( 0.0A)	0.12A	4oaeA-1ixlA: 0.3	4oaeA-1ixlA: 19.51

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2Q64_B_1UNB1001_2","PROTEASE RETROPEPSIN;PROTEASE RETROPEPSIN","1ixl","HYPOTHETICAL PROTEIN PH1136","Pyrococcus horikoshii",3,"ARG A 109;THR A  78;VAL A 114","ARG A 109 ( 0.6A);THR A  78 ( 0.8A);VAL A 114 ( 0.6A)","0.89A","2q64A-1ixlA:0.0","2q64A-1ixlA:24.81"],["2QQC_E_AG2E671_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC);PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC)","1ixl","HYPOTHETICAL PROTEIN PH1136","Pyrococcus horikoshii",4,"GLN A   6;LEU A  61;LEU A  54;GLY A  53","GLN A   6 ( 0.6A);LEU A  61 ( 0.6A);LEU A  54 ( 0.6A);GLY A  53 ( 0.0A)","0.91A","2qqcD-1ixlA:0.0;2qqcE-1ixlA:undetectable","2qqcD-1ixlA:20.59;2qqcE-1ixlA:12.21"],["4OAD_A_CLMA206_0","GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794","1ixl","HYPOTHETICAL PROTEIN PH1136","Pyrococcus horikoshii",4,"ALA A  55;ALA A  58;ALA A  59;ALA A  62","ALA A  55 ( 0.0A);ALA A  58 ( 0.0A);ALA A  59 ( 0.0A);ALA A  62 ( 0.0A)","0.12A","4oadA-1ixlA:0.0","4oadA-1ixlA:21.11"],["4OAE_A_CLMA208_0","GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794","1ixl","HYPOTHETICAL PROTEIN PH1136","Pyrococcus horikoshii",4,"ALA A  55;ALA A  58;ALA A  59;ALA A  62","ALA A  55 ( 0.0A);ALA A  58 ( 0.0A);ALA A  59 ( 0.0A);ALA A  62 ( 0.0A)","0.12A","4oaeA-1ixlA:0.3","4oaeA-1ixlA:19.51"]]