SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ixp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 VAL A   8
GLY A   7
LEU A   6
GLY A 215
LEU A 237
 None
None
None
PO4  A1002 (-3.4A)
None
 0.96A 1fduA-1ixpA:
undetectable		 1fduA-1ixpA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		4 / 7 VAL A   8
GLY A  41
THR A  67
ILE A  42
 None
 0.68A 1gtnC-1ixpA:
undetectable
1gtnD-1ixpA:
undetectable		 1gtnC-1ixpA:
14.46
1gtnD-1ixpA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		4 / 8 GLY A  41
ALA A  34
THR A  67
ILE A  42
 None
 0.83A 1gtnP-1ixpA:
undetectable
1gtnQ-1ixpA:
undetectable		 1gtnP-1ixpA:
14.46
1gtnQ-1ixpA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  65
GLU A 211
GLY A   7
ALA A  39
ALA A  37
 None
 1.14A 2bm9A-1ixpA:
undetectable		 2bm9A-1ixpA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  65
GLU A 211
GLY A   7
ALA A  39
ALA A  37
 None
 1.06A 2bm9C-1ixpA:
undetectable		 2bm9C-1ixpA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  65
GLU A 211
GLY A   7
ALA A  39
ALA A  37
 None
 0.96A 2br4A-1ixpA:
undetectable		 2br4A-1ixpA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 GLU A 211
GLY A  41
ASP A  40
ALA A  39
ALA A  37
 None
 1.27A 2br4B-1ixpA:
undetectable		 2br4B-1ixpA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  65
GLU A 211
GLY A   7
ALA A  39
ALA A  37
 None
 0.96A 2br4D-1ixpA:
undetectable		 2br4D-1ixpA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		4 / 6 LEU A 227
VAL A 231
ILE A 218
ILE A  13
 None
 0.87A 2piwA-1ixpA:
0.0		 2piwA-1ixpA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		6 / 11 ALA A 222
ILE A 218
ILE A  13
ALA A  30
ALA A  34
VAL A 231
 None
 1.40A 2qhfA-1ixpA:
undetectable		 2qhfA-1ixpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 ALA A 178
THR A 156
TYR A 159
LEU A 172
LEU A 212
 None
 1.19A 2rctA-1ixpA:
undetectable		 2rctA-1ixpA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		4 / 5 ARG A 221
ALA A 230
ASP A 229
GLU A 233
 None
 1.50A 2xrzA-1ixpA:
1.1		 2xrzA-1ixpA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		4 / 7 ASN A   9
ALA A  31
ALA A  30
ALA A  34
 PO4  A1001 ( 4.1A)
None
None
None
 0.64A 3a2qA-1ixpA:
0.0		 3a2qA-1ixpA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		4 / 5 VAL A 147
GLN A 140
PHE A 151
ARG A 117
 None
 1.45A 3bjwE-1ixpA:
0.0		 3bjwE-1ixpA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 ALA A  81
ALA A  83
PRO A  88
VAL A  58
THR A  86
 None
 1.16A 3cwkA-1ixpA:
undetectable		 3cwkA-1ixpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 10 ALA A 191
ILE A 214
GLY A 194
ALA A 202
ILE A 203
 None
PO4  A1002 (-4.4A)
PO4  A1002 (-3.5A)
None
None
 1.02A 3ekwA-1ixpA:
undetectable		 3ekwA-1ixpA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 ALA A 191
ILE A 214
GLY A 194
ALA A 202
ILE A 203
 None
PO4  A1002 (-4.4A)
PO4  A1002 (-3.5A)
None
None
 0.89A 3ekwB-1ixpA:
undetectable		 3ekwB-1ixpA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		3 / 3 GLU A 211
GLU A  72
ASN A  70
 None
 0.86A 3lp9B-1ixpA:
undetectable
3lp9D-1ixpA:
0.0		 3lp9B-1ixpA:
20.87
3lp9D-1ixpA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A 239
ALA A 204
ILE A 206
GLY A 192
ILE A 214
LEU A   4
 None
None
None
None
PO4  A1002 (-4.4A)
None
 1.25A 3ogpA-1ixpA:
0.0		 3ogpA-1ixpA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		3 / 3 ASP A 114
LYS A 115
ASP A 118
 None
 0.75A 4a7tA-1ixpA:
undetectable		 4a7tA-1ixpA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		4 / 7 LEU A  93
ARG A 122
PRO A  88
VAL A  84
 None
 1.23A 4klrA-1ixpA:
1.1		 4klrA-1ixpA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		4 / 8 ALA A 149
ASP A 137
ILE A 134
ILE A 154
 None
 0.91A 4kttB-1ixpA:
undetectable		 4kttB-1ixpA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 MET A 238
ILE A 214
VAL A   8
LEU A   6
ALA A 230
 None
PO4  A1002 (-4.4A)
None
None
None
 1.29A 4m11A-1ixpA:
0.0		 4m11A-1ixpA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 MET A 238
ILE A 214
VAL A   8
LEU A   6
ALA A 230
 None
PO4  A1002 (-4.4A)
None
None
None
 1.31A 4m11C-1ixpA:
undetectable		 4m11C-1ixpA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 MET A 238
ILE A 214
VAL A   8
LEU A   6
ALA A 230
 None
PO4  A1002 (-4.4A)
None
None
None
 1.28A 4m11D-1ixpA:
undetectable		 4m11D-1ixpA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		4 / 8 ALA A 149
ASP A 137
ILE A 134
ILE A 154
 None
 0.92A 4ndnB-1ixpA:
0.0		 4ndnB-1ixpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		4 / 8 ALA A 149
ASP A 137
ILE A 134
ILE A 154
 None
 0.91A 4ndnD-1ixpA:
undetectable		 4ndnD-1ixpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 ALA A 178
THR A 156
TYR A 159
LEU A 172
LEU A 212
 None
 1.29A 4qynA-1ixpA:
undetectable		 4qynA-1ixpA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 ALA A 178
THR A 156
TYR A 159
LEU A 172
LEU A 212
 None
 1.32A 4qzuB-1ixpA:
undetectable		 4qzuB-1ixpA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 ASP A  26
ARG A  56
ILE A  42
PHE A  32
ILE A  33
 None
 1.22A 5b8iC-1ixpA:
undetectable		 5b8iC-1ixpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 12 ALA A 191
GLY A 192
GLY A 194
LYS A 235
LEU A 237
 None
None
PO4  A1002 (-3.5A)
None
None
 1.05A 5c0oH-1ixpA:
undetectable		 5c0oH-1ixpA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		3 / 3 THR A 164
ASP A 165
ALA A 166
 None
 0.08A 5g5gB-1ixpA:
0.0		 5g5gB-1ixpA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 8 ILE A 203
VAL A 200
ILE A  10
ILE A  33
ILE A  42
 None
 1.14A 5hi2A-1ixpA:
undetectable		 5hi2A-1ixpA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		3 / 3 HIS A 216
HIS A  12
ARG A  51
 None
PO4  A1001 (-3.9A)
PO4  A1001 ( 4.9A)
 1.01A 6b58A-1ixpA:
undetectable		 6b58A-1ixpA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE
(Escherichia
coli) 		4 / 7 ALA A 149
ASP A 137
ILE A 134
ILE A 154
 None
 0.87A 6fbnA-1ixpA:
undetectable		 6fbnA-1ixpA:
20.79