SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ixr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1ixr RUVB
(Thermus
thermophilus) 		4 / 8 LEU C  28
THR C 140
LEU C  41
ALA C  55
 None
 0.91A 1fiqC-1ixrC:
undetectable		 1fiqC-1ixrC:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1ixr HOLLIDAY JUNCTION
DNA HELICASE RUVA
(Thermus
thermophilus) 		3 / 3 LEU A  92
PRO A  93
LEU A  96
 None
 0.51A 1hrkA-1ixrA:
undetectable		 1hrkA-1ixrA:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 1ixr RUVB
(Thermus
thermophilus) 		4 / 4 GLY C 266
LEU C 267
GLY C 301
ARG C 302
 None
 0.61A 1j7kA-1ixrC:
12.7		 1j7kA-1ixrC:
53.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1ixr RUVB
(Thermus
thermophilus) 		3 / 3 THR C 145
GLU C 283
ASP C 277
 None
 0.78A 1nt2A-1ixrC:
0.5		 1nt2A-1ixrC:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ixr RUVB
(Thermus
thermophilus) 		4 / 7 GLY C  63
THR C 140
ILE C  93
GLY C  91
 None
 0.85A 1usqA-1ixrC:
undetectable		 1usqA-1ixrC:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 1ixr HOLLIDAY JUNCTION
DNA HELICASE RUVA
(Thermus
thermophilus) 		5 / 11 LEU A  97
VAL A  84
ALA A  87
LEU A  86
LEU A  74
 None
 1.33A 2c12F-1ixrA:
0.0		 2c12F-1ixrA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 1ixr HOLLIDAY JUNCTION
DNA HELICASE RUVA
(Thermus
thermophilus) 		5 / 11 LEU A 101
VAL A  84
ALA A  87
LEU A  86
LEU A  74
 None
 1.13A 2c12F-1ixrA:
0.0		 2c12F-1ixrA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ixr RUVB
(Thermus
thermophilus) 		4 / 7 GLY C  63
THR C 140
ILE C  93
GLY C  91
 None
 0.86A 2jklA-1ixrC:
undetectable		 2jklA-1ixrC:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ixr RUVB
(Thermus
thermophilus) 		4 / 7 GLY C  63
THR C 140
ILE C  93
GLY C  91
 None
 0.86A 2jklC-1ixrC:
undetectable		 2jklC-1ixrC:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ixr RUVB
(Thermus
thermophilus) 		4 / 7 GLY C  63
THR C 140
ILE C  93
GLY C  91
 None
 0.86A 2jklD-1ixrC:
undetectable		 2jklD-1ixrC:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ixr RUVB
(Thermus
thermophilus) 		4 / 7 GLY C  63
THR C 140
ILE C  93
GLY C  91
 None
 0.87A 2jklF-1ixrC:
0.0		 2jklF-1ixrC:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1ixr RUVB
(Thermus
thermophilus) 		5 / 12 ALA C 308
LEU C 245
LEU C 289
LEU C 274
THR C 305
 None
 1.31A 2oipB-1ixrC:
undetectable		 2oipB-1ixrC:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1ixr HOLLIDAY JUNCTION
DNA HELICASE RUVA
(Thermus
thermophilus) 		5 / 12 PHE A  71
PHE A  62
LEU A  68
GLU A  72
ARG A   3
 None
 1.43A 3apvA-1ixrA:
0.0		 3apvA-1ixrA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1ixr HOLLIDAY JUNCTION
DNA HELICASE RUVA
(Thermus
thermophilus) 		5 / 12 PHE A  71
PHE A  62
LEU A  68
GLU A  72
ARG A   3
 None
 1.39A 3apwB-1ixrA:
undetectable		 3apwB-1ixrA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1ixr RUVB
(Thermus
thermophilus) 		3 / 3 PRO C  37
THR C 140
LEU C  62
 None
 0.79A 3ttrA-1ixrC:
undetectable		 3ttrA-1ixrC:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1ixr RUVB
(Thermus
thermophilus) 		4 / 8 LEU C  28
THR C 140
LEU C  41
ALA C  55
 None
 0.84A 3uniB-1ixrC:
undetectable		 3uniB-1ixrC:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ixr RUVB
(Thermus
thermophilus) 		5 / 12 ALA C 308
LEU C 245
LEU C 289
LEU C 274
THR C 305
 None
 1.28A 4q0dC-1ixrC:
undetectable		 4q0dC-1ixrC:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ixr RUVB
(Thermus
thermophilus) 		5 / 12 ALA C 308
LEU C 245
LEU C 289
LEU C 274
THR C 305
 None
 1.28A 4q0dD-1ixrC:
2.1		 4q0dD-1ixrC:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1ixr RUVB
(Thermus
thermophilus) 		3 / 3 LEU C  54
LEU C 165
ARG C 209
 None
 0.60A 5hnzB-1ixrC:
undetectable		 5hnzB-1ixrC:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1ixr RUVB
(Thermus
thermophilus) 		5 / 7 ARG C 158
LEU C 156
ALA C 153
ILE C  99
LEU C  42
 None
 1.34A 5te8C-1ixrC:
undetectable		 5te8C-1ixrC:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ixr RUVB
(Thermus
thermophilus) 		4 / 5 ARG C 205
MET C 204
THR C 203
LEU C 173
 None
ANP  C 313 (-4.4A)
None
None
 1.44A 5x1bW-1ixrC:
0.0		 5x1bW-1ixrC:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ixr RUVB
(Thermus
thermophilus) 		4 / 5 ARG C 209
MET C 204
THR C 203
LEU C 173
 None
ANP  C 313 (-4.4A)
None
None
 1.38A 5z86J-1ixrC:
0.0		 5z86J-1ixrC:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1ixr HOLLIDAY JUNCTION
DNA HELICASE RUVA
(Thermus
thermophilus) 		4 / 8 LEU A  28
LEU A  59
LEU A  20
GLY A  22
 None
 0.89A 6ce2A-1ixrA:
undetectable		 6ce2A-1ixrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1ixr HOLLIDAY JUNCTION
DNA HELICASE RUVA
(Thermus
thermophilus) 		4 / 8 LEU A  28
LEU A  59
LEU A  20
GLY A  23
 None
 0.88A 6ce2A-1ixrA:
undetectable		 6ce2A-1ixrA:
20.21