SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iy1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		5 / 12 GLY A 261
LEU A 279
LEU A 283
ALA A 299
PHE A 317
 None
 1.07A 1gseB-1iy1A:
undetectable		 1gseB-1iy1A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		4 / 8 GLY A 201
HIS A 204
ALA A 161
ILE A 323
 ADP  A   1 (-3.0A)
ADP  A   1 (-4.1A)
None
None
 0.77A 1gtnE-1iy1A:
undetectable
1gtnF-1iy1A:
undetectable		 1gtnE-1iy1A:
13.39
1gtnF-1iy1A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		4 / 8 GLY A 201
HIS A 204
ALA A 161
ILE A 323
 ADP  A   1 (-3.0A)
ADP  A   1 (-4.1A)
None
None
 0.81A 1gtnP-1iy1A:
undetectable
1gtnQ-1iy1A:
undetectable		 1gtnP-1iy1A:
13.39
1gtnQ-1iy1A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		3 / 3 ASP A 287
PHE A 241
ASN A 280
 None
 0.68A 1sg9B-1iy1A:
undetectable		 1sg9B-1iy1A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		4 / 5 LEU A 350
LEU A 353
LEU A 365
LEU A 369
 None
 0.85A 2ab2B-1iy1A:
undetectable		 2ab2B-1iy1A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		5 / 9 GLY A 201
ILE A 321
VAL A 209
ILE A 251
VAL A 296
 ADP  A   1 (-3.0A)
None
None
None
None
 1.35A 2nnhB-1iy1A:
undetectable		 2nnhB-1iy1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		5 / 8 ALA A 310
PRO A 309
GLU A 276
LEU A 279
LEU A 283
 None
 1.28A 4jjkA-1iy1A:
2.3		 4jjkA-1iy1A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		5 / 11 ALA A 310
LEU A 311
GLY A 261
ILE A 171
LEU A 175
 None
 0.95A 4kt0A-1iy1A:
0.0
4kt0J-1iy1A:
0.0		 4kt0A-1iy1A:
17.49
4kt0J-1iy1A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)		 1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		4 / 4 HIS A 204
ALA A 208
VAL A 153
GLU A 212
 ADP  A   1 (-4.1A)
None
None
None
 1.45A 4n6pA-1iy1A:
0.0		 4n6pA-1iy1A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		5 / 11 LEU A 283
LEU A 311
THR A 301
ALA A 299
VAL A 297
 None
 1.01A 4x20D-1iy1A:
undetectable		 4x20D-1iy1A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		5 / 10 ALA A 310
LEU A 311
GLY A 261
ILE A 171
LEU A 175
 None
 0.96A 5oy01-1iy1A:
undetectable
5oy07-1iy1A:
0.0		 5oy01-1iy1A:
14.46
5oy07-1iy1A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		5 / 12 MET A 298
ALA A 208
LEU A 194
ILE A 321
ASP A 324
 None
 1.41A 5vlmA-1iy1A:
undetectable		 5vlmA-1iy1A:
22.39