SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iy2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		4 / 4 THR A 278
LEU A 279
LEU A 312
GLN A 320
 None
 1.23A 1fbmA-1iy2A:
0.0		 1fbmA-1iy2A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		4 / 8 GLY A 201
HIS A 204
ALA A 161
ILE A 323
 SO4  A 101 (-3.5A)
None
None
None
 0.76A 1gtnE-1iy2A:
undetectable
1gtnF-1iy2A:
undetectable		 1gtnE-1iy2A:
13.60
1gtnF-1iy2A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		4 / 8 GLY A 201
HIS A 204
ALA A 161
ILE A 323
 SO4  A 101 (-3.5A)
None
None
None
 0.81A 1gtnP-1iy2A:
undetectable
1gtnQ-1iy2A:
undetectable		 1gtnP-1iy2A:
13.60
1gtnQ-1iy2A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		3 / 3 ASP A 287
PHE A 241
ASN A 280
 None
 0.61A 1sg9B-1iy2A:
undetectable		 1sg9B-1iy2A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		4 / 8 ILE A 251
LEU A 175
ARG A 207
GLY A 211
 None
 0.93A 2vdbA-1iy2A:
0.0		 2vdbA-1iy2A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		5 / 11 ALA A 310
LEU A 311
GLY A 261
ILE A 171
LEU A 175
 None
 1.02A 4kt0A-1iy2A:
undetectable
4kt0J-1iy2A:
0.0		 4kt0A-1iy2A:
19.32
4kt0J-1iy2A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		5 / 12 LEU A 283
LEU A 311
THR A 301
ALA A 299
VAL A 297
 None
 0.97A 4x1yB-1iy2A:
undetectable		 4x1yB-1iy2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		5 / 12 LEU A 283
LEU A 311
THR A 301
ALA A 299
VAL A 297
 None
 0.98A 4x20B-1iy2A:
0.0		 4x20B-1iy2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		5 / 11 LEU A 283
LEU A 311
THR A 301
ALA A 299
VAL A 297
 None
 0.95A 4x20D-1iy2A:
undetectable		 4x20D-1iy2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH
(Thermus
thermophilus) 		5 / 10 ALA A 310
LEU A 311
GLY A 261
ILE A 171
LEU A 175
 None
 0.98A 5oy01-1iy2A:
undetectable
5oy07-1iy2A:
0.0		 5oy01-1iy2A:
14.02
5oy07-1iy2A:
12.22