SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iy8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 12 SER A 152
VAL A 153
GLY A 154
TYR A 165
GLY A 196
 NAD  A1268 (-2.5A)
None
None
MRD  A1269 ( 3.9A)
NAD  A1268 (-3.8A)
 0.51A 1fduA-1iy8A:
28.8		 1fduA-1iy8A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 12 VAL A 153
GLY A 154
GLY A 196
LEU A 210
SER A 206
 None
None
NAD  A1268 (-3.8A)
None
MRD  A1269 ( 3.7A)
 1.08A 1fduA-1iy8A:
28.8		 1fduA-1iy8A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 12 SER A 152
VAL A 153
GLY A 154
TYR A 165
GLY A 196
 NAD  A1268 (-2.5A)
None
None
MRD  A1269 ( 3.9A)
NAD  A1268 (-3.8A)
 0.49A 1fduC-1iy8A:
28.8		 1fduC-1iy8A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 11 SER A 152
VAL A 153
GLY A 154
TYR A 165
GLY A 196
 NAD  A1268 (-2.5A)
None
None
MRD  A1269 ( 3.9A)
NAD  A1268 (-3.8A)
 0.37A 1iolA-1iy8A:
27.9		 1iolA-1iy8A:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		4 / 4 THR A 200
GLY A  22
ASP A  44
ALA A 100
 NAD  A1268 (-2.8A)
NAD  A1268 ( 4.1A)
NAD  A1268 (-2.7A)
NAD  A1268 ( 3.7A)
 1.22A 1sg9A-1iy8A:
7.1		 1sg9A-1iy8A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 12 GLY A  22
ALA A  30
VAL A  45
SER A  46
ASN A  99
 NAD  A1268 ( 4.1A)
None
NAD  A1268 (-3.9A)
None
NAD  A1268 (-3.3A)
 1.16A 1sg9C-1iy8A:
7.1		 1sg9C-1iy8A:
25.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		6 / 11 GLY A  20
SER A  23
ASP A  44
ASP A  72
VAL A  73
ALA A 100
 NAD  A1268 (-3.4A)
NAD  A1268 (-2.7A)
NAD  A1268 (-2.7A)
NAD  A1268 (-3.5A)
NAD  A1268 (-3.5A)
NAD  A1268 ( 3.7A)
 0.49A 1uayA-1iy8A:
30.2		 1uayA-1iy8A:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		6 / 10 GLY A  20
SER A  23
ASP A  44
ASP A  72
VAL A  73
ALA A 100
 NAD  A1268 (-3.4A)
NAD  A1268 (-2.7A)
NAD  A1268 (-2.7A)
NAD  A1268 (-3.5A)
NAD  A1268 (-3.5A)
NAD  A1268 ( 3.7A)
 0.53A 1uayB-1iy8A:
30.1		 1uayB-1iy8A:
34.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 12 GLY A  20
GLY A  22
ASP A  72
VAL A  73
ILE A 123
 NAD  A1268 (-3.4A)
NAD  A1268 ( 4.1A)
NAD  A1268 (-3.5A)
NAD  A1268 (-3.5A)
NAD  A1268 ( 3.9A)
 0.88A 1zq9B-1iy8A:
6.4		 1zq9B-1iy8A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 12 GLY A  20
ASP A  44
ASP A  72
ASN A  99
ALA A 100
 NAD  A1268 (-3.4A)
NAD  A1268 (-2.7A)
NAD  A1268 (-3.5A)
NAD  A1268 (-3.3A)
NAD  A1268 ( 3.7A)
 0.91A 2bm9E-1iy8A:
5.7		 2bm9E-1iy8A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 12 VAL A  73
ASP A  72
SER A 122
GLY A 104
ILE A 102
 NAD  A1268 (-3.5A)
NAD  A1268 (-3.5A)
None
None
NAD  A1268 ( 4.9A)
 1.18A 3a65A-1iy8A:
0.0		 3a65A-1iy8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 12 GLY A  20
GLY A  22
SER A  46
ASP A  72
VAL A  73
 NAD  A1268 (-3.4A)
NAD  A1268 ( 4.1A)
None
NAD  A1268 (-3.5A)
NAD  A1268 (-3.5A)
 0.86A 3dlcA-1iy8A:
6.1		 3dlcA-1iy8A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 12 ILE A 156
GLY A 155
ALA A 167
VAL A 173
ASN A 149
 None
 1.01A 3jb3A-1iy8A:
0.0		 3jb3A-1iy8A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 10 LEU A  40
ALA A  28
GLY A  26
ILE A  18
PHE A  11
 None
 1.42A 3qpsA-1iy8A:
1.8		 3qpsA-1iy8A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		4 / 7 ASN A 149
ALA A 192
ARG A 189
ALA A 180
 None
 0.92A 3twpB-1iy8A:
3.6		 3twpB-1iy8A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		4 / 7 ASN A 149
ALA A 192
ARG A 189
ALA A 180
 None
 0.98A 3twpC-1iy8A:
4.6		 3twpC-1iy8A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 11 SER A 122
GLU A 116
SER A  74
ASP A  72
VAL A  45
 None
None
NAD  A1268 ( 4.7A)
NAD  A1268 (-3.5A)
NAD  A1268 (-3.9A)
 1.14A 4d9hA-1iy8A:
undetectable		 4d9hA-1iy8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 9 SER A 122
GLU A 116
SER A  74
ASP A  72
VAL A  45
 None
None
NAD  A1268 ( 4.7A)
NAD  A1268 (-3.5A)
NAD  A1268 (-3.9A)
 1.28A 4da6A-1iy8A:
2.0		 4da6A-1iy8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		4 / 7 ALA A 100
GLY A  24
GLY A  21
ILE A  18
 NAD  A1268 ( 3.7A)
NAD  A1268 (-3.3A)
None
None
 0.65A 4eatA-1iy8A:
3.7		 4eatA-1iy8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		4 / 7 SER A 152
GLN A 162
TYR A 165
MET A 202
 NAD  A1268 (-2.5A)
MRD  A1269 (-3.7A)
MRD  A1269 ( 3.9A)
NAD  A1268 (-3.5A)
 0.62A 4hxyB-1iy8A:
19.7		 4hxyB-1iy8A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 12 GLY A  20
GLY A  22
SER A  46
ASP A  72
ILE A 123
 NAD  A1268 (-3.4A)
NAD  A1268 ( 4.1A)
None
NAD  A1268 (-3.5A)
NAD  A1268 ( 3.9A)
 0.78A 4krhA-1iy8A:
6.9		 4krhA-1iy8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 11 GLY A  20
GLY A  21
THR A  29
ASP A  44
ASP A  72
 NAD  A1268 (-3.4A)
None
None
NAD  A1268 (-2.7A)
NAD  A1268 (-3.5A)
 0.96A 4pghA-1iy8A:
6.0		 4pghA-1iy8A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 10 THR A  19
THR A 150
ALA A 151
ALA A 192
GLY A 127
 None
NAD  A1268 (-3.8A)
None
None
None
 0.90A 4qvyK-1iy8A:
undetectable
4qvyL-1iy8A:
undetectable		 4qvyK-1iy8A:
24.19
4qvyL-1iy8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 10 THR A  19
THR A 150
ALA A 151
ALA A 192
VAL A 147
 None
NAD  A1268 (-3.8A)
None
None
None
 0.96A 4qvyK-1iy8A:
undetectable
4qvyL-1iy8A:
undetectable		 4qvyK-1iy8A:
24.19
4qvyL-1iy8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 10 THR A  19
THR A 150
ALA A 151
ALA A 192
GLY A 127
 None
NAD  A1268 (-3.8A)
None
None
None
 0.90A 4qvyY-1iy8A:
undetectable
4qvyZ-1iy8A:
undetectable		 4qvyY-1iy8A:
24.19
4qvyZ-1iy8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 10 THR A  19
THR A 150
ALA A 151
ALA A 192
VAL A 147
 None
NAD  A1268 (-3.8A)
None
None
None
 0.96A 4qvyY-1iy8A:
undetectable
4qvyZ-1iy8A:
undetectable		 4qvyY-1iy8A:
24.19
4qvyZ-1iy8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		4 / 8 GLU A 141
LEU A 132
VAL A  83
GLY A 145
 None
 0.77A 4r3aA-1iy8A:
undetectable		 4r3aA-1iy8A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		4 / 7 VAL A 256
ALA A 194
GLY A 154
ARG A 177
 None
 0.76A 5fpdB-1iy8A:
2.0		 5fpdB-1iy8A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 12 GLY A  20
GLY A  22
SER A  46
ASP A  72
VAL A  73
 NAD  A1268 (-3.4A)
NAD  A1268 ( 4.1A)
None
NAD  A1268 (-3.5A)
NAD  A1268 (-3.5A)
 1.03A 5kpcB-1iy8A:
undetectable		 5kpcB-1iy8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 10 ARG A 140
ILE A  93
GLY A 131
ASN A  98
ALA A  81
 None
 1.25A 5x66D-1iy8A:
0.0		 5x66D-1iy8A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 12 GLY A  22
SER A  53
PHE A  97
ASN A  99
VAL A 241
 NAD  A1268 ( 4.1A)
None
None
NAD  A1268 (-3.3A)
None
 1.35A 6a94A-1iy8A:
undetectable		 6a94A-1iy8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1iy8 LEVODIONE REDUCTASE
(Leifsonia
aquatica) 		5 / 12 GLY A  24
ALA A  28
PHE A  97
ASN A  99
VAL A 148
 NAD  A1268 (-3.3A)
None
None
NAD  A1268 (-3.3A)
None
 1.12A 6bqgA-1iy8A:
0.6		 6bqgA-1iy8A:
15.51