SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iy9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_D_THAD4_1 (LIVER CARBOXYLESTERASE I)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	6 / 12	GLY A 89 GLY A 88 VAL A 134 LEU A 105 LEU A 127 LEU A 120	None	1.40A	1mx1D-1iy9A: 3.0	1mx1D-1iy9A: 19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_F_THAF6_1 (LIVER CARBOXYLESTERASE I)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	6 / 12	GLY A 89 GLY A 88 VAL A 134 LEU A 105 LEU A 127 LEU A 120	None	1.34A	1mx1F-1iy9A: 2.6	1mx1F-1iy9A: 19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N2X_B_SAMB402_0 (S-ADENOSYL-METHYLTRA NSFERASE MRAW)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	6 / 12	GLY A 86 GLY A 88 GLY A 89 HIS A 63 ASP A 109 VAL A 112	None	1.46A	1n2xB-1iy9A: 12.2	1n2xB-1iy9A: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBH_A_SAMA293_1 (GLYCINE N-METHYLTRANSFERASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	3 / 3	ARG A 247 ASP A 183 ASN A 148	None	0.95A	1nbhA-1iy9A: 10.9	1nbhA-1iy9A: 22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QAO_A_SAMA245_0 (ERMC' METHYLTRANSFERASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	GLY A 84 GLY A 86 ILE A 108 ASP A 109 ASP A 138	None	0.83A	1qaoA-1iy9A: 8.1	1qaoA-1iy9A: 23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SQF_A_SAMA430_0 (SUN PROTEIN)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	6 / 12	GLY A 88 GLY A 89 ILE A 108 ASP A 109 ASP A 138 GLY A 139	None	0.64A	1sqfA-1iy9A: 8.3	1sqfA-1iy9A: 20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZMA_A_ACAA501_1 (6-AMINOHEXANOATE-DIM ER HYDROLASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	4 / 8	ALA A 264 TYR A 255 ILE A 260 TYR A 256	None	1.05A	2zmaA-1iy9A: 0.0	2zmaA-1iy9A: 22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZA_A_FOLA164_0 (DIHYDROFOLATE REDUCTASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	MET A 154 LEU A 71 ILE A 91 LEU A 95 ARG A 131	None	1.26A	2zzaA-1iy9A: 2.1	2zzaA-1iy9A: 19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZA_B_FOLB164_0 (DIHYDROFOLATE REDUCTASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 11	MET A 154 LEU A 71 ILE A 91 LEU A 95 ARG A 131	None	1.28A	2zzaB-1iy9A: undetectable	2zzaB-1iy9A: 19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3B7P_A_SPMA501_1 (SPERMIDINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	GLN A 189 HIS A 63 TYR A 224 PRO A 225 ILE A 221	None	1.43A	3b7pA-1iy9A: 36.6	3b7pA-1iy9A: 39.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3B7P_A_SPMA501_1 (SPERMIDINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	HIS A 63 ASP A 87 TYR A 224 PRO A 225 ILE A 221	None	1.47A	3b7pA-1iy9A: 36.6	3b7pA-1iy9A: 39.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3B7P_A_SPMA501_1 (SPERMIDINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	TYR A 62 HIS A 63 ASP A 87 TYR A 224 PRO A 225	None	0.47A	3b7pA-1iy9A: 36.6	3b7pA-1iy9A: 39.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3B7P_B_SPMB502_1 (SPERMIDINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	GLN A 189 HIS A 63 TYR A 224 PRO A 225 ILE A 221	None	1.46A	3b7pB-1iy9A: 37.1	3b7pB-1iy9A: 39.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3B7P_B_SPMB502_1 (SPERMIDINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	HIS A 63 ASP A 87 TYR A 224 PRO A 225 ILE A 221	None	1.42A	3b7pB-1iy9A: 37.1	3b7pB-1iy9A: 39.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3B7P_B_SPMB502_1 (SPERMIDINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	TYR A 62 HIS A 63 ASP A 87 TYR A 224 PRO A 225	None	0.42A	3b7pB-1iy9A: 37.1	3b7pB-1iy9A: 39.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3B7P_C_SPMC503_1 (SPERMIDINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	GLN A 189 HIS A 63 TYR A 224 PRO A 225 ILE A 221	None	1.42A	3b7pC-1iy9A: 37.2	3b7pC-1iy9A: 39.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3B7P_C_SPMC503_1 (SPERMIDINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	HIS A 63 ASP A 87 TYR A 224 PRO A 225 ILE A 221	None	1.42A	3b7pC-1iy9A: 37.2	3b7pC-1iy9A: 39.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3B7P_C_SPMC503_1 (SPERMIDINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	TYR A 62 HIS A 63 ASP A 87 TYR A 224 PRO A 225	None	0.42A	3b7pC-1iy9A: 37.2	3b7pC-1iy9A: 39.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BWC_A_SAMA501_0 (SPERMIDINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	GLN A 32 GLY A 85 ASP A 109 VAL A 112 GLN A 189	None	1.02A	3bwcA-1iy9A: 36.4	3bwcA-1iy9A: 40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BWC_A_SAMA501_0 (SPERMIDINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	9 / 12	GLN A 32 TYR A 62 HIS A 63 GLY A 84 ASP A 109 VAL A 112 ASP A 138 GLY A 139 GLN A 189	None	0.64A	3bwcA-1iy9A: 36.4	3bwcA-1iy9A: 40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BWC_A_SAMA501_0 (SPERMIDINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	9 / 12	GLN A 32 TYR A 62 HIS A 63 GLY A 84 ILE A 108 ASP A 109 VAL A 112 ASP A 138 GLY A 139	None	0.51A	3bwcA-1iy9A: 36.4	3bwcA-1iy9A: 40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BWC_B_SAMB501_0 (SPERMIDINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	7 / 12	LEU A 48 TYR A 62 GLY A 84 ASP A 109 VAL A 112 ASP A 156 GLN A 189	None	1.45A	3bwcB-1iy9A: 36.3	3bwcB-1iy9A: 40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BWC_B_SAMB501_0 (SPERMIDINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	9 / 12	LEU A 48 TYR A 62 HIS A 63 GLY A 84 ASP A 87 ASP A 109 VAL A 112 GLY A 139 GLN A 189	None	0.64A	3bwcB-1iy9A: 36.3	3bwcB-1iy9A: 40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BWC_B_SAMB501_0 (SPERMIDINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	9 / 12	LEU A 48 TYR A 62 HIS A 63 GLY A 84 ASP A 87 ILE A 108 ASP A 109 VAL A 112 GLY A 139	None	0.47A	3bwcB-1iy9A: 36.3	3bwcB-1iy9A: 40.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3C6M_A_SPMA501_1 (SPERMINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 11	VAL A 52 ASP A 87 GLN A 189 TYR A 224 TRP A 229	None	0.98A	3c6mA-1iy9A: 23.5	3c6mA-1iy9A: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3C6M_A_SPMA501_1 (SPERMINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 11	VAL A 52 TYR A 62 ASP A 87 TYR A 224 TRP A 229	None	0.68A	3c6mA-1iy9A: 23.5	3c6mA-1iy9A: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3C6M_A_SPMA501_1 (SPERMINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 11	VAL A 52 TYR A 62 ASP A 156 TYR A 224 TRP A 229	None	1.08A	3c6mA-1iy9A: 23.5	3c6mA-1iy9A: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3C6M_C_SPMC501_1 (SPERMINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	6 / 10	VAL A 52 TYR A 62 ASP A 87 GLN A 189 TYR A 224 TRP A 229	None	0.89A	3c6mC-1iy9A: 23.3	3c6mC-1iy9A: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3C6M_C_SPMC501_1 (SPERMINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 10	VAL A 52 TYR A 62 ASP A 156 TYR A 224 TRP A 229	None	1.09A	3c6mC-1iy9A: 23.3	3c6mC-1iy9A: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3C6M_D_SPMD501_1 (SPERMINE SYNTHASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 10	TYR A 62 ASP A 87 GLN A 189 TYR A 224 TRP A 229	None	0.93A	3c6mD-1iy9A: 23.4	3c6mD-1iy9A: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FUU_A_ADNA0_1 (DIMETHYLADENOSINE TRANSFERASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	VAL A 83 GLY A 84 GLY A 86 ASP A 109 ASP A 138	None	0.74A	3fuuA-1iy9A: 10.4	3fuuA-1iy9A: 24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IA4_A_MTXA164_1 (DIHYDROFOLATE REDUCTASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	MET A 154 LEU A 71 ILE A 91 LEU A 95 ARG A 131	None	1.34A	3ia4A-1iy9A: 0.4	3ia4A-1iy9A: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IA4_C_MTXC164_1 (DIHYDROFOLATE REDUCTASE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	MET A 154 LEU A 71 ILE A 91 LEU A 95 ARG A 131	None	1.28A	3ia4C-1iy9A: undetectable	3ia4C-1iy9A: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WHX_B_XPGB301_1 (MAB FAB H FRAGMENT MAB FAB L FRAGMENT)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	VAL A 82 HIS A 97 HIS A 261 TYR A 256 GLU A 93	None	1.45A	3whxA-1iy9A: undetectable 3whxB-1iy9A: undetectable	3whxA-1iy9A: 22.56 3whxB-1iy9A: 21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A81_A_DXCA1161_0 (MAJOR POLLEN ALLERGEN BET V 1-A)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	GLY A 234 VAL A 83 TYR A 173 ASN A 166 LEU A 180	None	1.07A	4a81A-1iy9A: undetectable	4a81A-1iy9A: 23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A83_A_DXCA1161_0 (MAJOR POLLEN ALLERGEN BET V 1-A)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	GLY A 234 VAL A 83 TYR A 173 ASN A 166 LEU A 180	None	1.07A	4a83A-1iy9A: 0.8	4a83A-1iy9A: 23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B17_A_SAMA1358_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	GLY A 84 GLY A 88 GLY A 89 ASP A 107 ASP A 138	None	0.91A	4b17A-1iy9A: 10.4	4b17A-1iy9A: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IV8_A_SAMA301_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	GLY A 84 GLY A 86 ASP A 107 ILE A 108 ASP A 138	None	0.46A	4iv8A-1iy9A: 11.5	4iv8A-1iy9A: 24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IV8_B_SAMB301_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	GLY A 84 GLY A 86 ASP A 107 ILE A 108 ASP A 138	None	0.50A	4iv8B-1iy9A: 11.5	4iv8B-1iy9A: 24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XP3_A_DX4A401_0 (MITOGEN-ACTIVATED PROTEIN KINASE 1)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	4 / 6	ALA A 179 GLN A 149 LEU A 180 LEU A 81	None	1.08A	4xp3A-1iy9A: undetectable	4xp3A-1iy9A: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZJO_D_ERYD1101_0 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 11	THR A 54 ALA A 219 GLU A 93 ASP A 156 GLY A 85	None	1.45A	4zjoD-1iy9A: undetectable	4zjoD-1iy9A: 13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I1N_F_DVAF9_0 (D-VILLIN HEADPIECE SUBDOMAIN VILLIN-1)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	3 / 3	ALA A 164 ASN A 166 LEU A 167	None	0.51A	5i1nC-1iy9A: undetectable	5i1nC-1iy9A: 11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I1P_G_DVAG9_0 (D-VILLIN HEADPIECE SUBDOMAIN VILLIN-1)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	3 / 3	ALA A 164 ASN A 166 LEU A 167	None	0.47A	5i1pD-1iy9A: undetectable	5i1pD-1iy9A: 11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I6X_A_8PRA705_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 10	ALA A 177 ILE A 176 PHE A 211 GLY A 184 VAL A 207	None	1.02A	5i6xA-1iy9A: undetectable	5i6xA-1iy9A: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BQ4_A_ADNA401_1 (THERMOSPERMINE SYNTHASE ACAULIS PROTEIN)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	7 / 12	GLN A 32 GLY A 84 ASP A 107 ILE A 108 ASP A 109 VAL A 112 ASP A 137	None	1.47A	6bq4A-1iy9A: 33.0	6bq4A-1iy9A: 18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BQ4_A_ADNA401_1 (THERMOSPERMINE SYNTHASE ACAULIS PROTEIN)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	7 / 12	GLN A 32 GLY A 84 ASP A 107 ILE A 108 ASP A 109 VAL A 112 ASP A 138	None	0.55A	6bq4A-1iy9A: 33.0	6bq4A-1iy9A: 18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BQ4_B_ADNB401_1 (THERMOSPERMINE SYNTHASE ACAULIS PROTEIN)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	7 / 12	GLN A 32 GLY A 84 ASP A 107 ILE A 108 ASP A 109 VAL A 112 ASP A 137	None	1.41A	6bq4B-1iy9A: 33.3	6bq4B-1iy9A: 18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BQ4_B_ADNB401_1 (THERMOSPERMINE SYNTHASE ACAULIS PROTEIN)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	7 / 12	GLN A 32 GLY A 84 ASP A 107 ILE A 108 ASP A 109 VAL A 112 ASP A 138	None	0.45A	6bq4B-1iy9A: 33.3	6bq4B-1iy9A: 18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BQ4_B_ADNB401_1 (THERMOSPERMINE SYNTHASE ACAULIS PROTEIN)	1iy9	SPERMIDINE SYNTHASE (Bacillus subtilis)	5 / 12	GLN A 32 GLY A 85 ASP A 107 ASP A 109 VAL A 112	None	0.99A	6bq4B-1iy9A: 33.3	6bq4B-1iy9A: 18.35

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MX1_D_THAD4_1","LIVER CARBOXYLESTERASE I","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",6,"GLY A  89;GLY A  88;VAL A 134;LEU A 105;LEU A 127;LEU A 120","None","1.40A","1mx1D-1iy9A:3.0","1mx1D-1iy9A:19.02"],["1MX1_F_THAF6_1","LIVER CARBOXYLESTERASE I","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",6,"GLY A  89;GLY A  88;VAL A 134;LEU A 105;LEU A 127;LEU A 120","None","1.34A","1mx1F-1iy9A:2.6","1mx1F-1iy9A:19.02"],["1N2X_B_SAMB402_0","S-ADENOSYL-METHYLTRANSFERASE MRAW","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",6,"GLY A  86;GLY A  88;GLY A  89;HIS A  63;ASP A 109;VAL A 112","None","1.46A","1n2xB-1iy9A:12.2","1n2xB-1iy9A:21.02"],["1NBH_A_SAMA293_1","GLYCINE N-METHYLTRANSFERASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",3,"ARG A 247;ASP A 183;ASN A 148","None","0.95A","1nbhA-1iy9A:10.9","1nbhA-1iy9A:22.67"],["1QAO_A_SAMA245_0","ERMC' METHYLTRANSFERASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"GLY A  84;GLY A  86;ILE A 108;ASP A 109;ASP A 138","None","0.83A","1qaoA-1iy9A:8.1","1qaoA-1iy9A:23.23"],["1SQF_A_SAMA430_0","SUN PROTEIN","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",6,"GLY A  88;GLY A  89;ILE A 108;ASP A 109;ASP A 138;GLY A 139","None","0.64A","1sqfA-1iy9A:8.3","1sqfA-1iy9A:20.84"],["2ZMA_A_ACAA501_1","6-AMINOHEXANOATE-DIMER HYDROLASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",4,"ALA A 264;TYR A 255;ILE A 260;TYR A 256","None","1.05A","2zmaA-1iy9A:0.0","2zmaA-1iy9A:22.50"],["2ZZA_A_FOLA164_0","DIHYDROFOLATE REDUCTASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"MET A 154;LEU A  71;ILE A  91;LEU A  95;ARG A 131","None","1.26A","2zzaA-1iy9A:2.1","2zzaA-1iy9A:19.64"],["2ZZA_B_FOLB164_0","DIHYDROFOLATE REDUCTASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"MET A 154;LEU A  71;ILE A  91;LEU A  95;ARG A 131","None","1.28A","2zzaB-1iy9A:undetectable","2zzaB-1iy9A:19.64"],["3B7P_A_SPMA501_1","SPERMIDINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"GLN A 189;HIS A  63;TYR A 224;PRO A 225;ILE A 221","None","1.43A","3b7pA-1iy9A:36.6","3b7pA-1iy9A:39.08"],["3B7P_A_SPMA501_1","SPERMIDINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"HIS A  63;ASP A  87;TYR A 224;PRO A 225;ILE A 221","None","1.47A","3b7pA-1iy9A:36.6","3b7pA-1iy9A:39.08"],["3B7P_A_SPMA501_1","SPERMIDINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"TYR A  62;HIS A  63;ASP A  87;TYR A 224;PRO A 225","None","0.47A","3b7pA-1iy9A:36.6","3b7pA-1iy9A:39.08"],["3B7P_B_SPMB502_1","SPERMIDINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"GLN A 189;HIS A  63;TYR A 224;PRO A 225;ILE A 221","None","1.46A","3b7pB-1iy9A:37.1","3b7pB-1iy9A:39.08"],["3B7P_B_SPMB502_1","SPERMIDINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"HIS A  63;ASP A  87;TYR A 224;PRO A 225;ILE A 221","None","1.42A","3b7pB-1iy9A:37.1","3b7pB-1iy9A:39.08"],["3B7P_B_SPMB502_1","SPERMIDINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"TYR A  62;HIS A  63;ASP A  87;TYR A 224;PRO A 225","None","0.42A","3b7pB-1iy9A:37.1","3b7pB-1iy9A:39.08"],["3B7P_C_SPMC503_1","SPERMIDINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"GLN A 189;HIS A  63;TYR A 224;PRO A 225;ILE A 221","None","1.42A","3b7pC-1iy9A:37.2","3b7pC-1iy9A:39.08"],["3B7P_C_SPMC503_1","SPERMIDINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"HIS A  63;ASP A  87;TYR A 224;PRO A 225;ILE A 221","None","1.42A","3b7pC-1iy9A:37.2","3b7pC-1iy9A:39.08"],["3B7P_C_SPMC503_1","SPERMIDINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"TYR A  62;HIS A  63;ASP A  87;TYR A 224;PRO A 225","None","0.42A","3b7pC-1iy9A:37.2","3b7pC-1iy9A:39.08"],["3BWC_A_SAMA501_0","SPERMIDINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"GLN A  32;GLY A  85;ASP A 109;VAL A 112;GLN A 189","None","1.02A","3bwcA-1iy9A:36.4","3bwcA-1iy9A:40.75"],["3BWC_A_SAMA501_0","SPERMIDINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",9,"GLN A  32;TYR A  62;HIS A  63;GLY A  84;ASP A 109;VAL A 112;ASP A 138;GLY A 139;GLN A 189","None","0.64A","3bwcA-1iy9A:36.4","3bwcA-1iy9A:40.75"],["3BWC_A_SAMA501_0","SPERMIDINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",9,"GLN A  32;TYR A  62;HIS A  63;GLY A  84;ILE A 108;ASP A 109;VAL A 112;ASP A 138;GLY A 139","None","0.51A","3bwcA-1iy9A:36.4","3bwcA-1iy9A:40.75"],["3BWC_B_SAMB501_0","SPERMIDINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",7,"LEU A  48;TYR A  62;GLY A  84;ASP A 109;VAL A 112;ASP A 156;GLN A 189","None","1.45A","3bwcB-1iy9A:36.3","3bwcB-1iy9A:40.75"],["3BWC_B_SAMB501_0","SPERMIDINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",9,"LEU A  48;TYR A  62;HIS A  63;GLY A  84;ASP A  87;ASP A 109;VAL A 112;GLY A 139;GLN A 189","None","0.64A","3bwcB-1iy9A:36.3","3bwcB-1iy9A:40.75"],["3BWC_B_SAMB501_0","SPERMIDINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",9,"LEU A  48;TYR A  62;HIS A  63;GLY A  84;ASP A  87;ILE A 108;ASP A 109;VAL A 112;GLY A 139","None","0.47A","3bwcB-1iy9A:36.3","3bwcB-1iy9A:40.75"],["3C6M_A_SPMA501_1","SPERMINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"VAL A  52;ASP A  87;GLN A 189;TYR A 224;TRP A 229","None","0.98A","3c6mA-1iy9A:23.5","3c6mA-1iy9A:22.34"],["3C6M_A_SPMA501_1","SPERMINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"VAL A  52;TYR A  62;ASP A  87;TYR A 224;TRP A 229","None","0.68A","3c6mA-1iy9A:23.5","3c6mA-1iy9A:22.34"],["3C6M_A_SPMA501_1","SPERMINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"VAL A  52;TYR A  62;ASP A 156;TYR A 224;TRP A 229","None","1.08A","3c6mA-1iy9A:23.5","3c6mA-1iy9A:22.34"],["3C6M_C_SPMC501_1","SPERMINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",6,"VAL A  52;TYR A  62;ASP A  87;GLN A 189;TYR A 224;TRP A 229","None","0.89A","3c6mC-1iy9A:23.3","3c6mC-1iy9A:22.34"],["3C6M_C_SPMC501_1","SPERMINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"VAL A  52;TYR A  62;ASP A 156;TYR A 224;TRP A 229","None","1.09A","3c6mC-1iy9A:23.3","3c6mC-1iy9A:22.34"],["3C6M_D_SPMD501_1","SPERMINE SYNTHASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"TYR A  62;ASP A  87;GLN A 189;TYR A 224;TRP A 229","None","0.93A","3c6mD-1iy9A:23.4","3c6mD-1iy9A:22.34"],["3FUU_A_ADNA0_1","DIMETHYLADENOSINE TRANSFERASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"VAL A  83;GLY A  84;GLY A  86;ASP A 109;ASP A 138","None","0.74A","3fuuA-1iy9A:10.4","3fuuA-1iy9A:24.28"],["3IA4_A_MTXA164_1","DIHYDROFOLATE REDUCTASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"MET A 154;LEU A  71;ILE A  91;LEU A  95;ARG A 131","None","1.34A","3ia4A-1iy9A:0.4","3ia4A-1iy9A:20.83"],["3IA4_C_MTXC164_1","DIHYDROFOLATE REDUCTASE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"MET A 154;LEU A  71;ILE A  91;LEU A  95;ARG A 131","None","1.28A","3ia4C-1iy9A:undetectable","3ia4C-1iy9A:20.83"],["3WHX_B_XPGB301_1","MAB FAB H FRAGMENT;MAB FAB L FRAGMENT","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"VAL A  82;HIS A  97;HIS A 261;TYR A 256;GLU A  93","None","1.45A","3whxA-1iy9A:undetectable;3whxB-1iy9A:undetectable","3whxA-1iy9A:22.56;3whxB-1iy9A:21.18"],["4A81_A_DXCA1161_0","MAJOR POLLEN ALLERGEN BET V 1-A","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"GLY A 234;VAL A  83;TYR A 173;ASN A 166;LEU A 180","None","1.07A","4a81A-1iy9A:undetectable","4a81A-1iy9A:23.13"],["4A83_A_DXCA1161_0","MAJOR POLLEN ALLERGEN BET V 1-A","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"GLY A 234;VAL A  83;TYR A 173;ASN A 166;LEU A 180","None","1.07A","4a83A-1iy9A:0.8","4a83A-1iy9A:23.13"],["4B17_A_SAMA1358_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"GLY A  84;GLY A  88;GLY A  89;ASP A 107;ASP A 138","None","0.91A","4b17A-1iy9A:10.4","4b17A-1iy9A:21.48"],["4IV8_A_SAMA301_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE,PUTATIVE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"GLY A  84;GLY A  86;ASP A 107;ILE A 108;ASP A 138","None","0.46A","4iv8A-1iy9A:11.5","4iv8A-1iy9A:24.52"],["4IV8_B_SAMB301_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE,PUTATIVE","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"GLY A  84;GLY A  86;ASP A 107;ILE A 108;ASP A 138","None","0.50A","4iv8B-1iy9A:11.5","4iv8B-1iy9A:24.52"],["4XP3_A_DX4A401_0","MITOGEN-ACTIVATED PROTEIN KINASE 1","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",4,"ALA A 179;GLN A 149;LEU A 180;LEU A  81","None","1.08A","4xp3A-1iy9A:undetectable","4xp3A-1iy9A:21.98"],["4ZJO_D_ERYD1101_0","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"THR A  54;ALA A 219;GLU A  93;ASP A 156;GLY A  85","None","1.45A","4zjoD-1iy9A:undetectable","4zjoD-1iy9A:13.94"],["5I1N_F_DVAF9_0","D-VILLIN HEADPIECE SUBDOMAIN;VILLIN-1","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",3,"ALA A 164;ASN A 166;LEU A 167","None","0.51A","5i1nC-1iy9A:undetectable","5i1nC-1iy9A:11.18"],["5I1P_G_DVAG9_0","D-VILLIN HEADPIECE SUBDOMAIN;VILLIN-1","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",3,"ALA A 164;ASN A 166;LEU A 167","None","0.47A","5i1pD-1iy9A:undetectable","5i1pD-1iy9A:11.18"],["5I6X_A_8PRA705_1","SODIUM-DEPENDENT SEROTONIN TRANSPORTER","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"ALA A 177;ILE A 176;PHE A 211;GLY A 184;VAL A 207","None","1.02A","5i6xA-1iy9A:undetectable","5i6xA-1iy9A:19.35"],["6BQ4_A_ADNA401_1","THERMOSPERMINE SYNTHASE ACAULIS PROTEIN","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",7,"GLN A  32;GLY A  84;ASP A 107;ILE A 108;ASP A 109;VAL A 112;ASP A 137","None","1.47A","6bq4A-1iy9A:33.0","6bq4A-1iy9A:18.35"],["6BQ4_A_ADNA401_1","THERMOSPERMINE SYNTHASE ACAULIS PROTEIN","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",7,"GLN A  32;GLY A  84;ASP A 107;ILE A 108;ASP A 109;VAL A 112;ASP A 138","None","0.55A","6bq4A-1iy9A:33.0","6bq4A-1iy9A:18.35"],["6BQ4_B_ADNB401_1","THERMOSPERMINE SYNTHASE ACAULIS PROTEIN","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",7,"GLN A  32;GLY A  84;ASP A 107;ILE A 108;ASP A 109;VAL A 112;ASP A 137","None","1.41A","6bq4B-1iy9A:33.3","6bq4B-1iy9A:18.35"],["6BQ4_B_ADNB401_1","THERMOSPERMINE SYNTHASE ACAULIS PROTEIN","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",7,"GLN A  32;GLY A  84;ASP A 107;ILE A 108;ASP A 109;VAL A 112;ASP A 138","None","0.45A","6bq4B-1iy9A:33.3","6bq4B-1iy9A:18.35"],["6BQ4_B_ADNB401_1","THERMOSPERMINE SYNTHASE ACAULIS PROTEIN","1iy9","SPERMIDINE SYNTHASE","Bacillus subtilis",5,"GLN A  32;GLY A  85;ASP A 107;ASP A 109;VAL A 112","None","0.99A","6bq4B-1iy9A:33.3","6bq4B-1iy9A:18.35"]]