SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1iyb RIBONUCLEASE
(Nicotiana
glutinosa) 		4 / 8 LEU A 170
ILE A 173
ILE A 144
ILE A 148
 None
 0.80A 2bu8A-1iybA:
undetectable		 2bu8A-1iybA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1iyb RIBONUCLEASE
(Nicotiana
glutinosa) 		4 / 6 TYR A 110
TRP A  76
TYR A  60
GLN A  73
 None
 1.35A 2pgzD-1iybA:
0.0
2pgzE-1iybA:
0.0		 2pgzD-1iybA:
21.46
2pgzE-1iybA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 1iyb RIBONUCLEASE
(Nicotiana
glutinosa) 		3 / 3 SER A  87
HIS A 108
ASP A 116
 None
 0.71A 2wa2B-1iybA:
undetectable		 2wa2B-1iybA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 1iyb RIBONUCLEASE
(Nicotiana
glutinosa) 		3 / 3 PRO A  14
LEU A 123
SER A  34
 None
 0.62A 5fsaB-1iybA:
0.0		 5fsaB-1iybA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 1iyb RIBONUCLEASE
(Nicotiana
glutinosa) 		3 / 3 PRO A  14
LEU A 127
SER A  34
 None
 0.77A 5fsaB-1iybA:
0.0		 5fsaB-1iybA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 1iyb RIBONUCLEASE
(Nicotiana
glutinosa) 		3 / 3 LYS A  96
HIS A  92
HIS A  97
 5GP  A1295 (-2.5A)
5GP  A1295 (-3.9A)
5GP  A1295 (-4.1A)
 1.40A 5oexC-1iybA:
0.0		 5oexC-1iybA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 1iyb RIBONUCLEASE
(Nicotiana
glutinosa) 		5 / 10 PRO A  77
MET A  72
PRO A  27
SER A  87
GLY A  84
 None
 1.40A 5weoA-1iybA:
undetectable
5weoD-1iybA:
undetectable		 5weoA-1iybA:
11.55
5weoD-1iybA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_B_CYZB1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 1iyb RIBONUCLEASE
(Nicotiana
glutinosa) 		5 / 9 PRO A  77
MET A  72
PRO A  27
SER A  87
GLY A  84
 None
 1.39A 5weoB-1iybA:
undetectable
5weoC-1iybA:
0.1		 5weoB-1iybA:
11.55
5weoC-1iybA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_C_CYZC1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 1iyb RIBONUCLEASE
(Nicotiana
glutinosa) 		5 / 9 PRO A  27
SER A  87
GLY A  84
PRO A  77
MET A  72
 None
 1.39A 5weoB-1iybA:
0.0
5weoC-1iybA:
0.1		 5weoB-1iybA:
11.55
5weoC-1iybA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_D_CYZD1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 1iyb RIBONUCLEASE
(Nicotiana
glutinosa) 		5 / 9 PRO A  27
SER A  87
GLY A  84
PRO A  77
MET A  72
 None
 1.39A 5weoA-1iybA:
0.5
5weoD-1iybA:
undetectable		 5weoA-1iybA:
11.55
5weoD-1iybA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1iyb RIBONUCLEASE
(Nicotiana
glutinosa) 		5 / 12 ILE A 144
GLN A  11
PRO A  14
LEU A 170
PHE A  36
 None
 1.26A 5xxiA-1iybA:
undetectable		 5xxiA-1iybA:
18.36