SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iyl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		5 / 12 LEU A 415
CYH A 396
VAL A 448
GLY A 447
LEU A 450
 None
 1.26A 2bxeB-1iylA:
undetectable		 2bxeB-1iylA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		3 / 3 ASN A 201
TYR A 210
SER A 171
 None
 0.94A 2gvcB-1iylA:
0.0		 2gvcB-1iylA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 7 THR A 156
PRO A 157
VAL A 158
PRO A 130
 None
 0.95A 2v2gA-1iylA:
undetectable
2v2gB-1iylA:
undetectable		 2v2gA-1iylA:
20.00
2v2gB-1iylA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 7 PRO A 130
THR A 156
PRO A 157
VAL A 158
 None
 0.92A 2v2gA-1iylA:
undetectable
2v2gB-1iylA:
undetectable		 2v2gA-1iylA:
20.00
2v2gB-1iylA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 7 THR A 156
PRO A 157
VAL A 158
PRO A 130
 None
 0.95A 2v2gC-1iylA:
undetectable
2v2gD-1iylA:
undetectable		 2v2gC-1iylA:
20.00
2v2gD-1iylA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 7 PRO A 130
THR A 156
PRO A 157
VAL A 158
 None
 0.95A 2v2gC-1iylA:
undetectable
2v2gD-1iylA:
undetectable		 2v2gC-1iylA:
20.00
2v2gD-1iylA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 8 THR A 156
PRO A 157
VAL A 158
PRO A 130
 None
 0.87A 2v32A-1iylA:
undetectable
2v32B-1iylA:
undetectable		 2v32A-1iylA:
20.00
2v32B-1iylA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 8 PRO A 130
THR A 156
PRO A 157
VAL A 158
 None
 0.90A 2v32A-1iylA:
undetectable
2v32B-1iylA:
undetectable		 2v32A-1iylA:
20.00
2v32B-1iylA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 8 THR A 156
PRO A 157
VAL A 158
PRO A 130
 None
 0.97A 2v32C-1iylA:
undetectable
2v32D-1iylA:
undetectable		 2v32C-1iylA:
20.00
2v32D-1iylA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 8 PRO A 130
THR A 156
PRO A 157
VAL A 158
 None
 0.94A 2v32C-1iylA:
undetectable
2v32D-1iylA:
undetectable		 2v32C-1iylA:
20.00
2v32D-1iylA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 8 PRO A 130
THR A 156
PRO A 157
VAL A 158
 None
 1.03A 2v41C-1iylA:
undetectable
2v41D-1iylA:
undetectable		 2v41C-1iylA:
20.00
2v41D-1iylA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 7 THR A 156
PRO A 157
VAL A 158
PRO A 130
 None
 0.89A 2v41E-1iylA:
undetectable
2v41F-1iylA:
undetectable		 2v41E-1iylA:
20.00
2v41F-1iylA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 7 PRO A 130
THR A 156
PRO A 157
VAL A 158
 None
 0.99A 2v41E-1iylA:
undetectable
2v41F-1iylA:
undetectable		 2v41E-1iylA:
20.00
2v41F-1iylA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 8 THR A 156
PRO A 157
VAL A 158
PRO A 130
 None
 0.98A 2v41G-1iylA:
undetectable
2v41H-1iylA:
undetectable		 2v41G-1iylA:
20.00
2v41H-1iylA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 8 PRO A 130
THR A 156
PRO A 157
VAL A 158
 None
 0.96A 2v41G-1iylA:
undetectable
2v41H-1iylA:
undetectable		 2v41G-1iylA:
20.00
2v41H-1iylA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		3 / 3 LEU A 281
TYR A 285
GLN A 286
 None
 0.72A 2wekA-1iylA:
undetectable		 2wekA-1iylA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 8 ASN A 392
ILE A 352
PHE A 117
TYR A 354
 R64  A 452 (-3.4A)
None
R64  A 452 ( 4.2A)
R64  A 452 ( 4.6A)
 1.46A 3ccfB-1iylA:
undetectable		 3ccfB-1iylA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 6 VAL A 448
SER A 171
LEU A 128
LEU A 450
 None
 0.95A 3kk6A-1iylA:
undetectable		 3kk6A-1iylA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		3 / 3 PRO A 229
SER A 241
ASN A 231
 None
 0.93A 3lslG-1iylA:
0.0		 3lslG-1iylA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		3 / 3 ILE A 328
VAL A 320
ARG A 268
 None
 0.56A 3p73A-1iylA:
0.0		 3p73A-1iylA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 7 TYR A 225
LEU A 394
ASN A 392
TYR A 335
 R64  A 452 (-3.6A)
R64  A 452 (-4.6A)
R64  A 452 (-3.4A)
None
 1.31A 4f8yC-1iylA:
undetectable
4f8yD-1iylA:
undetectable		 4f8yC-1iylA:
18.88
4f8yD-1iylA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		4 / 7 TYR A 225
LEU A 415
ASN A 392
TYR A 335
 R64  A 452 (-3.6A)
None
R64  A 452 (-3.4A)
None
 1.26A 4f8yC-1iylA:
undetectable
4f8yD-1iylA:
undetectable		 4f8yC-1iylA:
18.88
4f8yD-1iylA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		5 / 12 LEU A 415
CYH A 396
VAL A 448
GLY A 447
LEU A 450
 None
 1.37A 4ot2A-1iylA:
undetectable		 4ot2A-1iylA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE
(Candida
albicans) 		3 / 3 ARG A 134
ASP A 136
TRP A 137
 None
 1.14A 4xdqA-1iylA:
undetectable		 4xdqA-1iylA:
20.00