SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iyr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WG7_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	1iyr	DNA FRAGMENTATION FACTOR ALPHA SUBUNIT (Homo sapiens)	4 / 6	ILE A 21 LEU A 22 ARG A 9 THR A 5	None	1.03A	3wg7A-1iyrA: undetectable 3wg7J-1iyrA: 0.0	3wg7A-1iyrA: 10.96 3wg7J-1iyrA: 24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDQ_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	1iyr	DNA FRAGMENTATION FACTOR ALPHA SUBUNIT (Homo sapiens)	4 / 7	ILE A 21 LEU A 22 ARG A 9 THR A 5	None	0.96A	5xdqA-1iyrA: undetectable 5xdqJ-1iyrA: 0.0	5xdqA-1iyrA: 10.96 5xdqJ-1iyrA: 24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZCQ_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	1iyr	DNA FRAGMENTATION FACTOR ALPHA SUBUNIT (Homo sapiens)	4 / 7	ILE A 21 LEU A 22 ARG A 9 THR A 5	None	0.95A	5zcqA-1iyrA: undetectable 5zcqJ-1iyrA: 0.0	5zcqA-1iyrA: 10.96 5zcqJ-1iyrA: 24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMF_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	1iyr	DNA FRAGMENTATION FACTOR ALPHA SUBUNIT (Homo sapiens)	4 / 6	ILE A 21 LEU A 22 ARG A 9 THR A 5	None	0.92A	6nmfN-1iyrA: undetectable 6nmfW-1iyrA: 0.0	6nmfN-1iyrA: 10.96 6nmfW-1iyrA: 24.04

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3WG7_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","1iyr","DNA FRAGMENTATION FACTOR ALPHA SUBUNIT","Homo sapiens",4,"ILE A  21;LEU A  22;ARG A   9;THR A   5","None","1.03A","3wg7A-1iyrA:undetectable;3wg7J-1iyrA:0.0","3wg7A-1iyrA:10.96;3wg7J-1iyrA:24.04"],["5XDQ_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","1iyr","DNA FRAGMENTATION FACTOR ALPHA SUBUNIT","Homo sapiens",4,"ILE A  21;LEU A  22;ARG A   9;THR A   5","None","0.96A","5xdqA-1iyrA:undetectable;5xdqJ-1iyrA:0.0","5xdqA-1iyrA:10.96;5xdqJ-1iyrA:24.04"],["5ZCQ_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","1iyr","DNA FRAGMENTATION FACTOR ALPHA SUBUNIT","Homo sapiens",4,"ILE A  21;LEU A  22;ARG A   9;THR A   5","None","0.95A","5zcqA-1iyrA:undetectable;5zcqJ-1iyrA:0.0","5zcqA-1iyrA:10.96;5zcqJ-1iyrA:24.04"],["6NMF_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","1iyr","DNA FRAGMENTATION FACTOR ALPHA SUBUNIT","Homo sapiens",4,"ILE A  21;LEU A  22;ARG A   9;THR A   5","None","0.92A","6nmfN-1iyrA:undetectable;6nmfW-1iyrA:0.0","6nmfN-1iyrA:10.96;6nmfW-1iyrA:24.04"]]