SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iyx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 10 GLU A 223
ALA A 224
LEU A 188
LEU A 211
GLU A 215
 None
 1.48A 1a29A-1iyxA:
0.0		 1a29A-1iyxA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 5 ARG A  51
LYS A  65
ALA A  66
GLY A 106
 None
 1.12A 1e7cA-1iyxA:
0.1		 1e7cA-1iyxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 5 HIS A 154
GLU A 163
ALA A 242
SER A 244
 None
MG  A1432 ( 4.7A)
None
None
 1.25A 1errA-1iyxA:
0.0
1errB-1iyxA:
0.0		 1errA-1iyxA:
20.76
1errB-1iyxA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 1iyx ENOLASE
(Enterococcus
hirae) 		3 / 3 GLU A  10
LYS A  65
VAL A  63
 None
 0.95A 1l2iA-1iyxA:
0.0		 1l2iA-1iyxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 7 ALA A 177
TYR A 403
ILE A 166
PRO A 168
 None
 1.09A 1oniA-1iyxA:
undetectable
1oniB-1iyxA:
undetectable		 1oniA-1iyxA:
15.70
1oniB-1iyxA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 6 ALA A 177
TYR A 403
ILE A 166
PRO A 168
 None
 1.08A 1oniB-1iyxA:
undetectable
1oniC-1iyxA:
undetectable		 1oniB-1iyxA:
15.70
1oniC-1iyxA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 7 TYR A 403
ILE A 166
PRO A 168
ALA A 177
 None
 1.03A 1oniD-1iyxA:
undetectable
1oniE-1iyxA:
undetectable		 1oniD-1iyxA:
15.70
1oniE-1iyxA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 11 ALA A 109
ILE A  73
ILE A  94
ALA A  77
ILE A  74
 None
 1.05A 2b60B-1iyxA:
undetectable		 2b60B-1iyxA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 12 LEU A 422
GLY A 233
ILE A 166
ILE A 283
VAL A 169
 None
 0.93A 2nnkB-1iyxA:
undetectable		 2nnkB-1iyxA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 5 LEU A 141
ALA A 381
ILE A 389
SER A 378
 None
 1.13A 2othA-1iyxA:
undetectable		 2othA-1iyxA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		3 / 3 SER A 369
GLU A 246
ASP A 291
 SO4  A1002 (-3.1A)
None
None
 0.81A 2zulA-1iyxA:
undetectable		 2zulA-1iyxA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		3 / 3 TYR A   7
GLU A  10
ASP A  54
 GOL  A2002 (-3.5A)
None
None
 0.78A 3bxoA-1iyxA:
undetectable		 3bxoA-1iyxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		3 / 3 TYR A   7
GLU A  10
ASP A  54
 GOL  A2002 (-3.5A)
None
None
 0.82A 3bxoB-1iyxA:
undetectable		 3bxoB-1iyxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		3 / 3 SER A 369
GLU A 246
ASP A 291
 SO4  A1002 (-3.1A)
None
None
 0.82A 3dmhA-1iyxA:
undetectable		 3dmhA-1iyxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 11 ALA A 333
ILE A 332
GLY A 331
SER A 335
LEU A 324
 None
 1.22A 3kw2A-1iyxA:
0.0		 3kw2A-1iyxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 9 ILE A  78
GLY A 112
ILE A 115
VAL A  83
ILE A   3
 None
 1.08A 3nu4A-1iyxA:
undetectable		 3nu4A-1iyxA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 7 ILE A 159
LEU A 211
LEU A 192
SER A 395
 None
 0.96A 3r9vA-1iyxA:
0.0
3r9vB-1iyxA:
0.0		 3r9vA-1iyxA:
20.27
3r9vB-1iyxA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 11 SER A 285
ILE A 284
VAL A 237
VAL A 169
ILE A 166
 None
 1.37A 3rf4A-1iyxA:
0.6
3rf4C-1iyxA:
0.5		 3rf4A-1iyxA:
13.46
3rf4C-1iyxA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 9 ALA A 109
ILE A  73
ILE A  94
ILE A  78
ILE A  74
 None
 0.95A 3s45A-1iyxA:
undetectable		 3s45A-1iyxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 11 ALA A 109
ILE A  73
ILE A  94
ILE A  78
ILE A  74
 None
 0.98A 3s45B-1iyxA:
undetectable		 3s45B-1iyxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 11 TYR A 281
GLY A 217
GLY A 151
ALA A 242
ALA A 243
 None
None
None
None
MG  A1432 ( 4.8A)
 1.12A 3sufC-1iyxA:
undetectable		 3sufC-1iyxA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 4 ASP A 291
ASP A 294
GLY A 289
THR A 302
 None
 1.21A 3tl9B-1iyxA:
undetectable		 3tl9B-1iyxA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 9 GLY A 151
ALA A 155
GLY A 206
ILE A 148
LEU A 197
 None
 1.05A 3u7sB-1iyxA:
undetectable		 3u7sB-1iyxA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 8 LEU A 197
ASN A 150
GLY A 151
ILE A 159
 None
 0.80A 3wxoA-1iyxA:
0.0		 3wxoA-1iyxA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 12 PHE A 425
ALA A 239
VAL A 312
LEU A 337
GLN A 310
 None
 1.10A 4j6dA-1iyxA:
undetectable		 4j6dA-1iyxA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 12 PHE A 425
ALA A 239
VAL A 312
LEU A 337
GLN A 310
 None
 1.09A 4j6dB-1iyxA:
0.5		 4j6dB-1iyxA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 12 PHE A 425
ALA A 239
VAL A 312
LEU A 337
GLN A 310
 None
 1.05A 4jbtA-1iyxA:
undetectable		 4jbtA-1iyxA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 12 GLY A 392
ASN A 147
MET A 146
ILE A 389
LEU A 337
 None
 1.06A 4kosA-1iyxA:
0.0		 4kosA-1iyxA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 12 GLY A 392
ASN A 147
MET A 146
SER A 366
LEU A 337
 None
 1.23A 4kowA-1iyxA:
0.3		 4kowA-1iyxA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 11 GLY A 392
ASN A 147
MET A 146
ILE A 389
LEU A 337
 None
 0.99A 4koyA-1iyxA:
0.3		 4koyA-1iyxA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 11 ASP A  85
VAL A  24
ALA A 116
SER A 114
THR A  26
 None
 1.24A 4mmaA-1iyxA:
undetectable		 4mmaA-1iyxA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 5 ASN A 157
ALA A 155
GLY A 151
ASP A 249
 None
 0.99A 4n48A-1iyxA:
undetectable		 4n48A-1iyxA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 6 LEU A 346
ASP A 374
VAL A 382
ALA A 381
 None
 1.13A 4nkvC-1iyxA:
0.0		 4nkvC-1iyxA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 12 GLY A 217
ILE A 286
MET A 240
PHE A 164
GLU A 204
 None
 1.04A 4r29D-1iyxA:
0.0		 4r29D-1iyxA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 7 GLY A 106
MET A  93
ALA A  66
ILE A  20
 None
 0.81A 4txnA-1iyxA:
undetectable		 4txnA-1iyxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 7 GLY A 106
MET A  93
ALA A  66
ILE A  20
 None
 0.85A 4txnB-1iyxA:
undetectable		 4txnB-1iyxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 7 GLY A 106
MET A  93
ALA A  66
ILE A  20
 None
 0.83A 4txnC-1iyxA:
undetectable		 4txnC-1iyxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 7 GLY A 106
MET A  93
ALA A  66
ILE A  20
 None
 0.83A 4txnD-1iyxA:
undetectable		 4txnD-1iyxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		4 / 4 ILE A 343
ASN A 341
ILE A 377
VAL A 365
 None
 1.18A 4uy87-1iyxA:
undetectable		 4uy87-1iyxA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1iyx ENOLASE
(Enterococcus
hirae) 		3 / 3 LEU A 178
ALA A 177
LEU A 407
 None
 0.50A 5uunB-1iyxA:
undetectable		 5uunB-1iyxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 1iyx ENOLASE
(Enterococcus
hirae) 		3 / 3 LEU A  50
ASP A  13
ILE A  11
 None
 0.61A 6dh0B-1iyxA:
undetectable		 6dh0B-1iyxA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1iyx ENOLASE
(Enterococcus
hirae) 		5 / 11 ASP A  82
VAL A  83
SER A   1
THR A  26
ALA A  30
 None
 1.21A 6dryA-1iyxA:
undetectable		 6dryA-1iyxA:
21.99