SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1iz1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		5 / 12 ILE A 219
ILE A 207
LEU A 191
LEU A 183
ILE A 259
 None
 1.06A 1bsxA-1iz1A:
undetectable		 1bsxA-1iz1A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		5 / 12 ILE A 219
ILE A 207
LEU A 191
LEU A 183
ILE A 259
 None
 1.06A 1bsxB-1iz1A:
undetectable		 1bsxB-1iz1A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		5 / 12 LEU A   6
ALA A  13
LEU A  57
LEU A  43
ILE A  71
 None
 1.13A 1s9pD-1iz1A:
undetectable		 1s9pD-1iz1A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		5 / 10 ALA A  63
PHE A  64
ALA A  68
LEU A  72
LEU A   6
 None
 1.00A 2bxqA-1iz1A:
undetectable		 2bxqA-1iz1A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		5 / 10 PHE A 177
GLY A 236
THR A 233
ALA A 238
ALA A 237
 None
 1.14A 2ej3B-1iz1A:
undetectable		 2ej3B-1iz1A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		5 / 12 ALA A  60
LEU A  43
ILE A  71
LEU A   6
THR A  58
 None
 1.29A 2zzaA-1iz1A:
undetectable		 2zzaA-1iz1A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		5 / 12 ILE A  55
ALA A  20
ILE A  10
ARG A  69
LEU A  65
 None
 1.26A 2zzaA-1iz1A:
undetectable		 2zzaA-1iz1A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		5 / 11 ALA A  60
LEU A  43
ILE A  71
LEU A   6
THR A  58
 None
 1.27A 2zzaB-1iz1A:
undetectable		 2zzaB-1iz1A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		5 / 10 SER A 269
LEU A 124
ILE A 102
PRO A 101
GLY A  99
 None
 1.24A 3ijxB-1iz1A:
11.2
3ijxD-1iz1A:
11.4		 3ijxB-1iz1A:
20.85
3ijxD-1iz1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		4 / 5 ASN A  17
ALA A  20
ALA A  15
ARG A  24
 None
 1.48A 3kp2B-1iz1A:
6.1		 3kp2B-1iz1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		5 / 12 PHE A 194
ALA A 229
ILE A 241
SER A 239
PHE A 202
 None
 1.47A 3lbdA-1iz1A:
undetectable		 3lbdA-1iz1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		5 / 10 PHE A 202
ALA A 229
THR A 233
ILE A 254
PHE A 256
 None
 1.48A 3t3qB-1iz1A:
undetectable		 3t3qB-1iz1A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		5 / 10 PHE A 202
ALA A 229
THR A 233
ILE A 254
PHE A 256
 None
 1.48A 3t3qC-1iz1A:
undetectable		 3t3qC-1iz1A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		5 / 10 PHE A 202
ALA A 229
THR A 233
ILE A 254
PHE A 256
 None
 1.47A 3t3qD-1iz1A:
0.0		 3t3qD-1iz1A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		3 / 3 PHE A 202
VAL A 266
GLU A 163
 None
 0.56A 4fvqA-1iz1A:
undetectable		 4fvqA-1iz1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		5 / 12 ILE A 219
ALA A 203
SER A 240
LEU A 191
LEU A 183
 None
 1.27A 4qztC-1iz1A:
undetectable		 4qztC-1iz1A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		5 / 12 VAL A 242
VAL A 246
LEU A 230
THR A 227
ALA A 228
 None
 1.27A 4yhaA-1iz1A:
undetectable		 4yhaA-1iz1A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		3 / 4 ARG A  53
GLY A  54
GLU A  56
 None
 0.67A 4z2dB-1iz1A:
1.5
4z2dC-1iz1A:
undetectable		 4z2dB-1iz1A:
20.52
4z2dC-1iz1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		4 / 5 SER A 123
GLY A 135
GLU A 134
ARG A  77
 None
 1.15A 5cdqA-1iz1A:
1.7
5cdqB-1iz1A:
undetectable
5cdqC-1iz1A:
1.0		 5cdqA-1iz1A:
19.34
5cdqB-1iz1A:
22.22
5cdqC-1iz1A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		4 / 5 SER A 123
GLY A 135
GLU A 134
ARG A  77
 None
 1.03A 5cdqR-1iz1A:
1.1
5cdqS-1iz1A:
undetectable
5cdqT-1iz1A:
1.1		 5cdqR-1iz1A:
19.34
5cdqS-1iz1A:
22.22
5cdqT-1iz1A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		4 / 4 VAL A 189
ALA A 238
ILE A 219
THR A 192
 None
 1.10A 5e4dB-1iz1A:
0.6		 5e4dB-1iz1A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 1iz1 LYSR-TYPE REGULATORY
PROTEIN
(Cupriavidus
necator) 		4 / 5 HIS A 142
ILE A 280
SER A 123
ALA A 120
 None
 1.20A 5msdA-1iz1A:
undetectable		 5msdA-1iz1A:
14.38